# of Displayed Technologies: 10 / 19


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Privacy-preserving Acoustic Signal based Encounter Detection in Physical Proximity
TS-050242 — A continuous on-line machine learning algorithm to sense and analyze the acoustic channels of surrounding environments first, and then dynamically adjust power, coding strategies and back-off mechanisms for real-time acoustic communications.
In light of the COVID-19 Pandemic, the world is looking to data which quantifies the self-quarantine measures, tracks encounters and viral spread, and provides other indicators that can be used for safety. WiFi and Bluetooth signals are relatively large which makes virus detection/tracking difficu…
  • College: College of Engineering (COE)
  • Inventors: Xuan, Dong; Luo, Yuxiang; Shroff, Ness; Zhang, Yunqi; Zhang, Cheng
  • Licensing Officer: Hong, Dongsung

Independent speed variable frequency generator for more electric aircraft using brushless doubly-fed machines (BDFM)
TS-050232 — Independent speed variable frequency generator for more electric aircraft using brushless doubly-fed machines (BDFM)
Technology continues to advance and with it, a push for higher performance of electrical components and devices, especially in the transportation industry. For example, in the past few decades, considerable efforts have been taken towards aircraft electrification. Traditional hydraulic and pneumat…
  • College: College of Engineering (COE)
  • Inventors: Zhang, Julia; Peng, Peng; Xu, Longya
  • Licensing Officer: Hong, Dongsung

New architecture for hybrid electric vehicles
TS-050218 — A brushless doubly-fed machine (BDFM) and drive system for vehicle propulsion.
The state-of-the-art electrified vehicle (EV) technology uses rare-earth based permanent magnet systems, which have the major drawbacks of price and availability of rare earth materials (as more than 95% of the rare earth magnetic materials are mined and processed in China). Alternative machines s…
  • College: College of Engineering (COE)
  • Inventors: Zhang, Julia; Peng, Peng; Xu, Longya
  • Licensing Officer: Hong, Dongsung

An improved base editor (iABE-NG) for correcting genetic diseases such as Duchenne muscular dystrophy
TS-049505 — An engineered base editor (iABE-NG) that uses an SpCas9 variant, a shortened adenine deaminase domain with eliminated RNA off-targeting activity, and an intein split for packaging into an adeno-associated virus (AAV), resulting in gene mutation correction.
There are thousands of monogenic diseases such as Duchenne muscular dystrophy (DMD) lacking effective therapeutic treatments. DMD is caused by genetic mutations in the DMD gene, which encodes the dystrophin protein. The mutations including missense point mutations, nonsense point mutations, deleti…
  • College: College of Medicine (COM)
  • Inventors: Han, Renzhi; Gao, Yandi; Xu, Li
  • Licensing Officer: Davis, Stewart

Integrated Biomanufacturing System for Fiber-Reinforced Tissue Composites
TS-047830 — An automated technique and system which combines electrospinning, additive manufacturing, and cell dispensing for generating high-quality tissue constructs with high physiological relevance.
Recent advances in biofabrication introduced by additive manufacturing/3D printing (AM/3DP) have significantly improved the overall architecture control in tissue engineered constructs. These constructs have a wide variety of important research and clinical applications including, but not limited …
  • College: College of Engineering (COE)
  • Inventors: Zhang, Xu; Herderick, Edward; Niu, Ye "Ye"; Zhao, Yi
  • Licensing Officer: Zinn, Ryan

Adoptive Transfer of Engineered Macrophages
TS-045881 — The Need Cell therapies have received recent approvals for immunomodulatory indications. Immuno-activating chimeric antigen receptor (CAR)–T cells have been developed for cancers, whereas immunosuppressive mesenchymal stromal cells (MSCs) have been approved for inflammatory bowel disease and …
  • College: College of Pharmacy
  • Inventors: Dong, Yizhou; Hou, Xucheng; Zhang, Xinfu
  • Licensing Officer: Flammang, Ann Marie

Adoptive Transfer of Engineered Macrophages
TS-045881 — The Need Cell therapies have received recent approvals for immunomodulatory indications. Immuno-activating chimeric antigen receptor (CAR)–T cells have been developed for cancers, whereas immunosuppressive mesenchymal stromal cells (MSCs) have been approved for inflammatory bowel disease and …
  • College: College of Pharmacy
  • Inventors: Dong, Yizhou; Hou, Xucheng; Zhang, Xinfu
  • Licensing Officer: Flammang, Ann Marie

Ultrasonic Resistance Spot Welding Process and Apparatus
TS-041781 — An improvement to ultrasonic and resistance spot welding
Ultrasonic welding is widely used in the electronics industry to weld together wiring in delicate circuits and on microcircuits. It is also used in the automotive industry, medical industry, and packaging industry, often to weld dissimilar materials or plastics. The major advantages in ultrasonic …
  • College: College of Engineering (COE)
  • Inventors: Liu, Xun; Benatar, Avraham; Kimchi, Menachem
  • Licensing Officer: Zinn, Ryan

Multifunctional RNA Nanoparticles and Methods for Treating Cancer
TS-040289 — Three-way junction nanoparticles for delivery of tamoxifen and other therapeutics directly to tumor cells.
Most breast cancers express estrogen receptor alpha (ER α) and antagonists of ER α drugs, such as tamoxifen, have been widely used for their treatment. Unfortunately, up to half of all ER α -positive tumors have intrinsic or acquired endocrine therapy resistance. Recent studies b…
  • College: College of Pharmacy
  • Inventors: Zhang, Xiaoting; Guo, Peixuan
  • Licensing Officer: Flammang, Ann Marie

Perivascular Drug Delivery Nanoplatform for Preventing Restenosis After Open Surgery
TS-039004 — Pericelle: a nanoparticle based perivascular drug delivery system to prevent stenosis and failure in vascular reconstruction surgeries
Imaging and re-intervention procedures, necessary to maintain open blood vessels following vascular reconstruction surgery, are expensive. For example, the cost of maintenance for an atriovenous (AV) fistula used in hemodialysis access has been estimated at near a staggering $15,000/year. In bypas…
  • College: College of Medicine (COM)
  • Inventors: Kent, K. Craig; Chen, Guojun; Gong, Shaoqin; Guo, Lianwang; Shi, Xudong
  • Licensing Officer: Norris, Francis "Frank"

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