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Sacrificial Layer to Facilitate Welding of Thin Foils
TS-065430 — Cost-effective method to prevent damaged electrodes when welding thin foils.
Manufacturing of automotive lithium-ion batteries and battery packs is attracting growing attention with the driving demands of electric vehicles. During battery assembly, multi-layers of metal films, functioning as anodes, cathodes, or bus-bars are welded together. Achieving satisfying weld quali…
  • College: College of Engineering (COE)
  • Inventors: Liu, Xun; Kwon, Ho; Shah, Umair
  • Licensing Officer: Zinn, Ryan

Self-filling Friction Stir Welding Processing
TS-065427 — The Ohio State University has developed a novel self-filling friction stir welding tool that eliminates keyhole defects caused by tool pin retraction.
Friction stir welding (FSW) and friction stir processing (FSP) are solid-state processes that utilize the heat generated from a rotating pin tool to soften the base metals for fusion and repair, respectively. However, keyhole defects are inevitably left after retracting the tool pin, which can ge…
  • College: College of Engineering (COE)
  • Inventors: Liu, Xun
  • Licensing Officer: Zinn, Ryan

A next generation intranasal trivalent Measles, Mumps and Covid vaccine
TS-064189 — The Need The current global landscape demands innovative solutions to address the urgent need for a safe and efficacious SARS-CoV-2 vaccine, particularly for the vulnerable population of infants and children under 12 years old. Existing vaccines face challenges in terms of durability, cost, and sta…
  • College: College of Veterinary Medicine
  • Inventors: Li, Jianrong; Xu, Jiayu; Zhang, Yuexiu
  • Licensing Officer: Dahlman, Jason "Jay"

Suppressing background carbon incorporation using laser-assisted MOCVD growth of nitride-based semiconductors
TS-063717 — The Need In the world of semiconductor material systems, the demand for advancements in optoelectronic and power electronic devices is ever-growing. The fabrication of semiconductor films, crucial for these applications, primarily relies on epitaxy technologies such as hydride vapor phase epitaxy (…
  • College: College of Engineering (COE)
  • Inventors: Zhao, Hongping; Chen, Zhaoying; Zhang, Yuxuan
  • Licensing Officer: Randhawa, Davinder

High-entropy AlCrTiV alloys
TS-063365 — Experience the future of materials technology with our high-entropy AlCrTiV metal alloy—a revolutionary solution that reshapes the possibilities in engineering and manufacturing. Elevate your products to new heights of performance, efficiency, and sustainability with our innovative alloy. For a closely related technology, please visit https://oied.osu.edu/find-technologies and type "T2021-261" in the search field.
In various industries, from aerospace to manufacturing, the pursuit of materials with exceptional mechanical properties coupled with low weight is unending. Conventional alloys often trade off one aspect for another, leaving a gap in the market for a metal alloy that seamlessly integrates strength…
  • College: College of Engineering (COE)
  • Inventors: Luo, Alan; Huang, Xuejun; Sun, Weihua
  • Licensing Officer: Zinn, Ryan

Metal Matrix Composites Reinforced by High Entropy Alloys
TS-063364 — Experience the future of advanced materials—our metal matrix composites offer a revolutionary approach to meeting the demands of modern industries. Elevate your products, enhance performance, and reduce costs with our groundbreaking technology. For a closely related technology, please visit https://oied.osu.edu/find-technologies and type "T2017-051" in the search field.
In the aerospace, defense, and automotive industries, there is a pressing demand for advanced materials that combine low weight, high strength, exceptional wear resistance, and superior high-temperature performance. Traditional methods using ceramic particles as reinforcements in aluminum matrix c…
  • College: College of Engineering (COE)
  • Inventors: Luo, Alan; Huang, Xuejun; Zhang, Jianyue
  • Licensing Officer: Zinn, Ryan

Novel functional surfaces for chemical reaction and water treatment
TS-063135 — A liquid crystal infused porous surface for diagnosing and treating wastewater.
In various industries, there is a growing need for surfaces that can effectively repel water and resist fouling by oily contaminants. Traditional superhydrophobic surfaces, while excellent at repelling water, are easily fouled, limiting their practical applications. A team of The Ohio State Uni…
  • College: College of Engineering (COE)
  • Inventors: Wang, Xiaoguang; Rather, Adil; Xu, Yang
  • Licensing Officer: Randhawa, Davinder

Thermotropic liquid crystal-based sensors for naked-eye detection of SARS-CoV-2 with ultrahigh sensitivity and selectivity
TS-063069 — In the wake of the global pandemic caused by SARS-CoV-2, the need for rapid, accurate, and efficient diagnostic methods for respiratory viral infections has become more critical than ever. Traditional diagnostic methods, while reliable, are often time-consuming, labor-intensive, and lack the neces…
  • College: College of Engineering (COE)
  • Inventors: Wang, Xiaoguang; Qin, Rongjun; Rather, Adil; Xu, Yang
  • Licensing Officer: Randhawa, Davinder

Method for Prediction of Artificial Intelligence Model Generalizability for Unseen Data
TS-063039 — Medical-based AI systems have seen increased use in recent years across a range of applications (e.g., diagnostics, prognostics, treatment response prediction). Their widespread adoption by the medical community is still restricted, primarily due to their limited ability to realize a high degree of …
  • College: College of Medicine (COM)
  • Inventors: Dikici, Engin; Nguyen, Xuan; Prevedello, Luciano
  • Licensing Officer: Hampton, Andrew

Addressing the Challenges in HCC Treatment with Innovative Technology
TS-062690 — Novel niclosamide analogues with improved bioavailability and mitigated dose-limiting toxicities.
Hepatocellular carcinoma (HCC) poses a significant global health challenge, being a predominant form of liver cancer with high mortality rates. The disease exhibits sexual dimorphism, disproportionately affecting males. The Need Despite the crucial role of androgen receptors (AR) in HCC progress…
  • College: College of Pharmacy
  • Inventors: Coss, Christopher; Cheng, Jeffrey; Cheng, Xiaolin; Kulp, Samuel; Li, Tom; Montgomery, Emma; Xing, Enming
  • Licensing Officer: Schultz, Teri

E-Cadherin-based Oncolytic Viral Cancer for Glioblastoma
TS-062682 — Glioblastoma (GBM) is the most common malignant brain tumor accounting for 47.7% of all brain cancers. Unfortunately, treatments are limited, and survival is poor, with approximately 40% living the first-year post-diagnosis and 17% in the second year. The Need Oncolytic viruses (OVs) are a prom…
  • College: College of Medicine (COM)
  • Inventors: Yu, Jianhua; Caligiuri, Michael; Xu, Bo
  • Licensing Officer: Taysavang, Panya

An innovative platform to enhance the efficacy of oncolytic virotherapy for cancer treatment through E-cadherin
TS-062679 — Glioblastoma (GBM) is the most common malignant brain tumor accounting for 47.7% of all brain cancers. Unfortunately, treatments are limited, and survival is poor, with approximately 40% living the first-year post-diagnosis and 17% in the second year. The Need Oncolytic viruses (OVs) are a prom…
  • College: College of Medicine (COM)
  • Inventors: Yu, Jianhua; Caligiuri, Michael; Xu, Bo
  • Licensing Officer: Taysavang, Panya

Visual Function Mapping Technology: Enhancing Vision Care and Diagnostics
TS-062335 — The Need: In the field of ophthalmology and vision care, there is a critical need for accurate and comprehensive measurements of visual function over the entire visual field. Conditions such as glaucoma, age-related macular degeneration (AMD), diabetes, stroke, pituitary disease, brain tumors, and n…
  • College: College of Arts & Sciences
  • Inventors: Lu, Zhong-Lin; Lesmes, Luis; Xu, Pengjing "PJ"; Yu, Deyue
  • Licensing Officer: Willson, Christopher

Novel method for attenuating live vaccine candidates for non-segmented negative-sense RNA viruses
TS-062213 — The Need: Preventing Respiratory Syncytial Virus (RSV) Infection and Disease Respiratory Syncytial Virus (RSV) is a highly prevalent and dangerous pathogen responsible for significant morbidity and mortality, particularly in infants, young children, and immunocompromised individuals. Despite its gl…
  • College: College of Veterinary Medicine
  • Inventors: Li, Jianrong; He, Chuan; Lu, Mijia; Niewiesk, Stefan; Peeples, Mark; Xue, Miaoge; Zhang, Zijie; Zhao, Boxuan
  • Licensing Officer: Dahlman, Jason "Jay"

Ultrasonically assisted wire additive manufacturing process and apparatus
TS-054013 — The ultrasonically assisted wire additive manufacturing process and apparatus is a new innovation that uses power ultrasound (UA) for benefits in processing molten metals. The UA energy is directly applied in the local deposition pool, which makes this new hybrid process applicable for building parts with any size and geometry.
Additive manufacturing (AM) is the process of 3D printing for industrial use. Instead of countertop devices printing small toys from plastic, industrial AM is used on a much larger scale to create engine blocks, plane components, and many other products made of metal alloys. AM is traditionally do…
  • College: College of Engineering (COE)
  • Inventors: Liu, Xun; Pfeifer, Eddie "Ed"; Wang, Tianzhao
  • Licensing Officer: Zinn, Ryan

Independent speed variable frequency generator for more electric aircraft using brushless doubly-fed machines (BDFM)
TS-050232 — Independent speed variable frequency generator for more electric aircraft using brushless doubly-fed machines (BDFM)
Technology continues to advance and with it, a push for higher performance of electrical components and devices, especially in the transportation industry. For example, in the past few decades, considerable efforts have been taken towards aircraft electrification. Traditional hydraulic and pneumat…
  • College: College of Engineering (COE)
  • Inventors: Zhang, Julia; Peng, Peng; Xu, Longya
  • Licensing Officer: Zinn, Ryan

An improved base editor (iABE-NG) for correcting genetic diseases such as Duchenne muscular dystrophy
TS-049505 — An engineered base editor (iABE-NG) that uses an SpCas9 variant, a shortened adenine deaminase domain with eliminated RNA off-target activity, and an intein split for packaging into an adeno-associated virus (AAV), resulting in gene mutation correction.
There are thousands of monogenic diseases that are lacking effective therapeutic treatments. The main bottleneck in developing effective treatment is the ability to effectively edit gene while controlling for the myriad of off-target effects that come with targeting the genome. Duchenne Muscular D…
  • College: College of Medicine (COM)
  • Inventors: Han, Renzhi; Gao, Yandi; Xu, Li
  • Licensing Officer: Schworer, Adam

A Model Based Assessment Approach and an Automation Environment for Qualification of Embedded Digital Devices
TS-042856 — A Framework and Automatization process designed to determine the functionality of Embedded Digital Devices.
As our technology becomes increasingly complex, so does the quantity and variation of the Embedded Digital Device [EDD] components that are required within the project. Because not every device is made perfectly to specifications due to a propagation of random error, it is important to have a dive…
  • College: College of Engineering (COE)
  • Inventors: Smidts, Carol; Diao, Xiaoxu; Li, Boyuan
  • Licensing Officer: Hampton, Andrew

Ultrasonic Resistance Spot Welding Process and Apparatus
TS-041781 — An improvement to ultrasonic and resistance spot welding
Ultrasonic welding is widely used in the electronics industry to weld together wiring in delicate circuits and on microcircuits. It is also used in the automotive industry, medical industry, and packaging industry, often to weld dissimilar materials or plastics. The major advantages in ultrasonic …
  • College: College of Engineering (COE)
  • Inventors: Liu, Xun; Benatar, Avraham "Avi"; Kimchi, Menachem
  • Licensing Officer: Zinn, Ryan

Perivascular Drug Delivery Nanoplatform for Preventing Restenosis After Open Surgery
TS-039004 — Pericelle: a nanoparticle based perivascular drug delivery system to prevent stenosis and failure in vascular reconstruction surgeries.
Imaging and re-intervention procedures, necessary to maintain open blood vessels following vascular reconstruction surgery, are expensive. For example, the cost of maintenance for an arteriovenous (AV) fistula used in hemodialysis access has been estimated at $15,000/year. In bypass and AV fistula…
  • College: College of Medicine (COM)
  • Inventors: Kent, K. Craig; Chen, Guojun; Gong, Shaoqin; Guo, Lianwang; Shi, Xudong
  • Licensing Officer: Taysavang, Panya

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