Small molecule inhibitor of the Ral small G proteins for triple-negative breast cancer (TNBC)
TS-075232 — Problem
Breast cancer (BC) is the most commonly diagnosed malignancy and the second leading cause of cancer-related death among women in the United States. Within its subtypes, triple-negative breast cancer (TNBC) carries the highest mortality, driven in large part by a lack of effective targeted t…
- College: College of Medicine (COM)
- Inventors: Sizemore, Steven; Lindert, Steffen
- Licensing Officer: Bhatti, Hamid
Tumor-DNA detection in plasma & urinary EVs for non-invasive cancer monitoring & treatment
TS-075182 — PROBLEM
Prostate cancer (PCa) and urothelial cancers (UC) are among the most commonly diagnosed malignancies in aging adults, and their management is characterized by prolonged, costly, and invasive surveillance pathways. Both diseases exhibit marked molecular heterogeneity that drives prognosis, t…
- College: College of Medicine (COM)
- Inventors: Sood, Akshay
- Licensing Officer: Bhatti, Hamid
CREB1-targeting PROTAC compounds for the treatment of Multiple Myeloma
TS-075178 — Problem
Over 30,000 Americans are diagnosed every year with multiple myeloma (MM), a disease of clonal plasma cells which accumulate in the bone marrow. Despite several treatment options, MM is still incurable, and patients inevitably relapse and develop toxicities and functional decline. Novel the…
- College: College of Medicine (COM)
- Inventors: Cottini, Francesca; Cocucci, Emanuele "Ema"
- Licensing Officer: Bhatti, Hamid
Revolutionizing Multiple Myeloma Treatment: Targeted Precision with CS1-Specific CAR Polypeptides
TS-065435 — The Need: The treatment landscape for multiple myeloma (MM) demands novel, targeted solutions to improve patient outcomes. Existing therapies often fall short in addressing the complex challenges posed by MM, necessitating a more precise and effective approach.
The Technology: Our technology introd…
- College: College of Medicine (COM)
- Inventors: Yu, Jianhua; Chu, Jianhong; Hofmeister, Craig
- Licensing Officer: Bhatti, Hamid
E-Cadherin-based Oncolytic Viral Cancer for Glioblastoma
TS-062682 — Glioblastoma (GBM) is the most common malignant brain tumor accounting for 47.7% of all brain cancers. Unfortunately, treatments are limited, and survival is poor, with approximately 40% living the first-year post-diagnosis and 17% in the second year.
The Need
Oncolytic viruses (OVs) are a prom…
- College: College of Medicine (COM)
- Inventors: Yu, Jianhua; Caligiuri, Michael; Xu, Bo
- Licensing Officer: Bhatti, Hamid