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Method to improve efficiency and specificity of human tumor targeting and elimination by using a combination of split & splice protein toxins and oncolytic viruses
TS-040838 — Novel strategy to improve efficiency and specificity of tumor treatment via combinative use of a split & splice protein toxin and oncolytic virus.
In combating malignancies as complex as cancer, researchers and clinicians have created a diverse set of strategies to reduce tumor burden. Oncolytic viruses (OVs) have emerged as a promising means of treating this disease due to their potential to selectively target and effectively kill cancer ce…
  • College: College of Arts & Sciences
  • Inventors: Kudryashov, Dmitri; Kudryashova, Elena
  • Licensing Officer: Flammang, Ann Marie

Small molecule modulators of Avian Pathogenic E. coli (APEC) virulence as a means to control avian collibacillosis
TS-040540 — Small Molecules have been developed that have shown effective defense against Avian pathogenic Escherichia coli (APEC). These molecules can be used by itself, or with current antibiotics, which helps decrease the overall risk of bacterial antibiotic resistance.
Avian pathogenic Escherichia coli (APEC) is one of the most common poultry diseases that is characterized by a series of extra intestinal infections that effect the visceral organs of the bird. The disease affects chickens, turkeys, and other avian species, and highly reduces egg production and we…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Rajashekara, Gireesh; Deblais, Loic; Kathayat, Dipak; Mohamed, Yosra
  • Licensing Officer: Dahlman, Jason "Jay"

Novel compositions of nanoparticles for nucleic acid therapeutic delivery
TS-040254 — Novel lipid-based nanoparticles that utilize a surfactant to improve self-assembly and stability. Finalized particles can be used for delivery of nucleic acids such as oligonucleotides and plasmid DNA.
Lipid-based nanoparticles (LNPs) have been extensively utilized in nucleic acid delivery. However, there are a number of challenges associated with LNP formulation. It is difficult to make sub-100-nm LNPs with a high nucleic acid concentration by traditional self-assembly methods. LNP synthesis ty…
  • College: College of Pharmacy
  • Inventors: Lee, Robert
  • Licensing Officer: Flammang, Ann Marie

The OSU Soil Organic Matter Calculator
TS-040136 — The Ohio State University’s Soil Organic Matter Calculator is a program that can be used to calculate future organic soil quality, greenhouse gas emissions, nitrogen fertility over short- and long-term scenarios in rder to help farmers decide more sustainable methods of agriculture.
Farmers, scientists, educators, industries and other non-profit organizations are increasing in need of a simple way to make accurate models and simulations of the environmental impact of land management choices and practices. Various different group and organizations from a wide variety of indust…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Islam, Khandakar; Grigar, Jerry; Reeder, Randall; Shedekar, Vinayak
  • Licensing Officer: Dahlman, Jason "Jay"

Identifying the level of lupus patients’ comprehension of their medication regimens and disease outcomes
TS-040132 — A questionnaire used to understand a patient’s comprehension of their personalized medication plan and the disease fluctuation of systemic lupus erythematous (SLE).
Systemic lupus erythematous (SLE) is an autoimmune disease in which the body’s immune system attacks healthy tissue in its own body. The disease has a prevalance of twenty to 150 cases per 100,000 individuals, and is more common in females than in men. This chronic disease has no cure, and s…
  • College: College of Medicine (COM)
  • Inventors: Meara, Alexa; Ardoin, Stacy; Peters, Ellen
  • Licensing Officer: Dahlman, Jason "Jay"

The FoodImage Smartphone App
TS-040080 — FoodImage quantifies food waste in near real-time using images of food products and food waste captured by end users or consumers.
Americans throw away approximately 80 billion pounds of food per year. However, in a study conducted by The Ohio State University, 53% of respondents indicated that food waste is a problem. A potential method to reduce food waste and its negative affects would be to increase awareness of the probl…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Roe, Brian; Apolzan, John; Martin, Corby
  • Licensing Officer: Dahlman, Jason "Jay"

Virtual image generation of immunohistochemical stained tissue sections using an artificial neural network
TS-039781 — Realistic immunohistochemical stained tissue section databases for training, certification, and machine standards.
Immunohistochemistry (IHC) is used to determine antigen distribution in a tissue and is widely used for diagnosis of cancers and other diseases. Diagnostic and research laboratories in the United States use locally devised IHC tissue slide preparation and scanning protocols to check scanner perfor…
  • College: College of Medicine (COM)
  • Inventors: Gurcan, Metin; Lozanski, Gerard; Senaras, Caglar
  • Licensing Officer: Norris, Francis "Frank"

Pulse of the OR: Reducing Operating Room Traffic for Patient Safety and Quality Initiatives
TS-039735 — A method of measuring traffic flow in an operating room to reduce contamination and ensure air quality.
Surgical site infections (SSI) can affect all surgical specialties and are an significant cause of long-term morbidity and mortality in the United States. With a rate of 2.8 infections per every 100 operations, these occurrences can lengthen hospital stays, double readmission rates, and can cost b…
  • College: College of Medicine (COM)
  • Inventors: Quatman, Carmen; Chaudhari, Ajit
  • Licensing Officer: Flammang, Ann Marie

Small molecule growth inhibitors of avian pathogenic E. coli (APEC) as a means to control APEC infections in poultry.
TS-039568 — Small Molecules have been developed that have shown effective defense against Avian pathogenic Escherichia coli (APEC). These molecules can be used by itself, or with current antibiotics, which helps decrease the overall risk of bacterial antibiotic resistance.
Avian pathogenic Escherichia coli (APEC) is one of the most common poultry diseases that is characterized by a series of extra intestinal infections that effect the visceral organs of the bird. The disease affects chickens, turkeys, and other avian species, and highly reduces egg production and we…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Rajashekara, Gireesh; Deblais, Loic; Kathayat, Dipak; Mohamed, Yosra
  • Licensing Officer: Dahlman, Jason "Jay"

Control of Salmonella in poultry using new generation small molecule growth inhibitors.
TS-039567 — Small molecule compounds that can be used to inhibit Salmonella growth for safe and sustainable poultry production.
Non-typhoidal Salmonella are among the top five intestinal pathogens in the United States. Among foodborne illnesses, they are responsible for 11% of illnesses, 35% of those hospitalizations, and 28% deaths, with an estimated cost of $3.6 billion. Poultry is the most common source of wide-scale Sa…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Rajashekara, Gireesh; Deblais, Loic; Kathayat, Dipak; Miller, Sally; Mohamed, Yosra
  • Licensing Officer: Dahlman, Jason "Jay"

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