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Novel predictors of responsiveness to CAR T-cell therapy
TS-075167 — PROBLEM CAR T-cell therapy against CD19 has become the standard of care for relapsed/refractory B-cell non-Hodgkin lymphoma (NHL), the most common kind of lymphoma. Recent studies have identified clinical risk factors for prediction of CAR T therapy failure; however, these risk factors are inconsis…
  • College: College of Medicine (COM)
  • Inventors: Yang, Yiping; Denlinger, Nathan
  • Licensing Officer: He, Panqing

OSU-185: first humanized proximal CD30-targeting CAR-T for durable remission in refract. lymphomas
TS-075162 — THE PROBLEM Despite advances in classical Hodgkin’s Lymphoma (cHL) treatment, significant challenges persist with up to 40% of patients relapsing after first-line therapy and 50% after autologous stem cell transplant (aSCT). Current therapies like brentuximab vedotin and checkpoint inhibitors…
  • College: College of Medicine (COM)
  • Inventors: Denlinger, Nathan; Chan, Wing Keung
  • Licensing Officer: He, Panqing

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