A novel approach to reverse T cell exhaustion to improve anti-cancer and anti-viral responses
TS-075186 — PROBLEM
Exhausted CD8 T cells significantly limit the effectiveness of immunotherapies and cell therapies in cancer and chronic viral infections. Persistent antigen exposure drives durable epigenetic reprogramming that locks T cells into a dysfunctional state, silencing effector and memory-associat…
- College: College of Medicine (COM)
- Inventors: Ghoneim, Hazem
- Licensing Officer: He, Panqing
