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Identification of DNA methylation profiles for targeted therapy in Acute Myeloid Leukemia and other cancers

TS-075244 — Problem Acute myeloid leukemia (AML), the most common acute leukemia in adults, is a clinically and molecularly heterogeneous disease. Sequencing of large patient cohorts has uncovered a complex mutational landscape in AML but still fails to completely explain the biological and clinical heterogene…

College: College of Medicine (COM)
Inventors: Oakes, Christopher; Blachly, James; Byrd, John
Licensing Officer: Schworer, Adam

A novel mouse model of spontaneous chronic lymphocytic leukemia

TS-055268 — The laboratory of Dr. Rosa Lapalombella in collaboration with Dr. James Blachly at The Ohio State University has developed a mouse model of spontaneous Chronic Lymphocytic Leukemia.

The Need Chronic lymphocytic leukemia (CLL) accounts for one quarter of new cases of leukemia. CLL is the most prevalent adult leukemia in Western countries and is characterized by a mature B-cell phenotype. Given the burden of this disease, a large pipeline of drugs for treatment are in progress…

College: College of Medicine (COM)
Inventors: Lapalombella, Rosa; Blachly, James; Byrd, John
Licensing Officer: Schworer, Adam