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AI-Enabled Retrosynthesis for Drug Development
TS-060092 — AI methods and systems for predicting reactants and their synthesis paths to support drug design and chemical synthesis.
A time-consuming and costly step in drug development is the identification of drug-like small molecules that display desired properties against a specific biomolecular target and then the synthesis of such molecules if they do not exist. Retrosynthesis is a procedure where such a desired molecule i…
  • College: College of Medicine (COM)
  • Inventors: Ning, Xia; Chen, Ziqi
  • Licensing Officer: Csatary, Erika

FraB as a drug target and FraB inhibitors as Salmonella-specific narrow-spectrum therapeutics
TS-059635 — & T2014-282 A method to discover narrow-spectrum antibiotics of salmonellosis, as well as small molecule inhibitors of Salmonella FraB and a Salmonella probiotic strain to enhance the efficacy of FraB inhibitors.
Non-typhoidal salmonellosis is one of the most significant food-borne diseases, in the United States and globally. There are no vaccines available for human use to prevent this disease, and only broad-spectrum antibiotics available to treat the disease. However, antibiotic resistance is on the ris…
  • College: College of Medicine (COM)
  • Inventors: Ahmer, Brian; Boulanger, Erin; Cool, Austin; Gopalan, Venkat; Kovvali, Sai Sravya Varali; Law, Jamison; Lindert, Steffen; Sabag-Daigle, Anice; Sengupta, Anindita; Thirugnanasambantham, Pankajavalli
  • Licensing Officer: Csatary, Erika

Diagnostic for Early Detection of Heart Damage
TS-059578 — A novel biomarker for the early identification of cardiac damage, including chemotherapy-induced cardiotoxicity.
Despite significant medical advances and technologies, cardiovascular disease remains the number one cause of death in the United States, irrespective of gender or race, resulting in more than 600,000 annual deaths. Additionally, while cancer survivorship has increased significantly, the number one …
  • College: College of Medicine (COM)
  • Inventors: Smith, Sakima; Dib, Patrick; McElroy, Craig
  • Licensing Officer: Csatary, Erika

Metabolite-Based Diagnostics for Joint Infection
TS-059537 — An untargeted NMR-based metabolomics approach to identify metabolic compounds as signatures of bacterial joint infections and methods for the treatment and prevention thereof.
Pseudomonas aeruginosa, a biofilm-producing pathogenic bacterium, exhibits resistance to many antibiotics. This leads to acute and chronic joint infections that are difficult to treat. Accordingly, a critical need exists for accurate biofilm diagnosis, prevention, and treatment. While culture-free…
  • College: College of Medicine (COM)
  • Inventors: Stoodley, Paul; Bruschweiler, Rafael; Leggett, Abigail
  • Licensing Officer: Csatary, Erika

SimPi: A Remote Power Platform for Simulation
TS-059056 — A platform for improving simulations across many industries. Developing real-life simulations of disasters is vital for safety and reducing their financial impact; however, current simulation tools are bulky, expensive to implement, and require advanced technical skills to operate.
Simulations are essential for evaluating the potential impacts of disasters and for creating effective preparedness and response plans to facilitate organized and coordinated actions. Since response plans are not theoretical exercises, they must frequently be tested to be evaluated, adapted, and u…
  • College: College of Medicine (COM)
  • Inventors: Winfield, Scott; Beck, James; Finnegan, Geoff
  • Licensing Officer: Csatary, Erika

Water treatment to eliminate cyanobacteria and other toxins by unmanned surface vehicles (USVs)
TS-058408 — Freshwater resources around the world are under stress due to naturally occurring events and human impacts, causing an increase in cyanobacteria blooms. These cyanobacteria release harmful toxins, known as cyanotoxins. The proposed USV degrades the toxins on-site with UV light, reducing the accumulation of toxins, preventing groundwater contamination, and improving water quality.
Treatment of cyanobacteria and cyanotoxins is necessary before they reach a critical point, or they can contaminate other environments. For example, waste produced by water treatment facilities serves as fertilizer for agricultural land, and if not properly treated, toxic cyanobacteria can grow in…
  • College: College of Public Health
  • Inventors: Lee, Jiyoung; Byrd, Kendall
  • Licensing Officer: Csatary, Erika

Nras Mouse Melanoma Cell Lines
TS-049491 — Dr. Christin Burd's lab at The Ohio State University has developed a set of Nras-mutant mouse melanoma cell lines that can be used for preclinical tumor immunology and cancer biology studies.
Studies show that 15-30% of melanomas are Nras driven and 60% of melanomas are Braf driven. Dr. Christin Burd's lab at The Ohio State University has developed a set of Nras-mutant mouse melanoma cell lines that complement a set of Braf cell lines developed by Marcus Bosenberg at Yale Universit…
  • College: College of Medicine (COM)
  • Inventors: Burd, Christin; Murphy, Brandon
  • Licensing Officer: Csatary, Erika

Transdermal Drug and Gene Therapy Delivery
TS-045224 — A new modality for delivering drugs and gene therapies.
Gene therapy is an emerging technology that replaces a faulty gene or adds a new gene to cure disease or improve your body's ability to fight disease. These next-generation treatments hold promise for treating various genetic and chronic diseases, including but not limited to cancer, cystic fibr…
  • College: College of Medicine (COM)
  • Inventors: Gallego Perez, Daniel; Higuita Castro, Natalia; Johnson, Jed; Ohst, Devan
  • Licensing Officer: Csatary, Erika

Improved Dressing Design for Insertion Sheaths with Side Ports
TS-044969 — Dressing designed and tailored exclusively for insertion sheaths with side ports, used frequently for pulmonary artery catheters (PACs or Swan-Ganz catheters) among other intravascular devices in the hospital.
Central-line associated blood stream infections (CLABSIs) are a life-threatening and extremely costly problem in hospitals around the world. When patients in the hospital have indwelling catheters such as pulmonary artery catheters, they are at an increased risk of developing infections. Occlusive…
  • College: OSU Wexner Medical Center
  • Inventors: Warren, Samantha; Thomas, Jordan
  • Licensing Officer: Csatary, Erika

A Small Molecule That Disperses Salmonella Biofilms
TS-041469 — A new compound to eliminate Salmonella biofilms to reduce typhoid fever.
The bacterium Salmonella enterica serovar Typhi (S. Typhi) is the causative agent of typhoid fever – infecting and killing an estimated 21 million and 200,000 individuals each year, respectively. Individuals contract the disease by consuming food or water contaminated with the etiologic agent …
  • College: College of Medicine (COM)
  • Inventors: Gunn, John; Huggins, William; Kuo, Laura; Melander, Christian
  • Licensing Officer: Csatary, Erika

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