TS-041764 — AR-12 is a FDA-IND approved small molecule that has been repurposed to treat leishmaniasis, a parasitic infection.
Leishmaniasis is a protozoal parasitic disease transmitted by sandflies. The disease affects millions of people worldwide. Sandflies carrying the promastigote form of the parasite bite a human host, attracting macrophages to the site of the wound. Promastigotes are then phagocytized by the macroph…