High-Throughput Perfusion Platform for Standard Multi-Well Assays
TS-075845 —
Drug discovery, biologics development, cell therapy research, and advanced in vitro testing all rely on large numbers of cell-based experiments. While continuous perfusion can improve biological relevance by maintaining nutrient availability, removing waste products, and better mimicking physiolog…
- College: College of Engineering (COE)
- Inventors: Agarwal, Shashwat; Jones, Travis; Song, Jonathan "Jon"
- Licensing Officer: Ashouripashaki, Mandana
Chip-to-World Interconnection Method for Microfluidic Device Integration
TS-075637 —
Microfluidic and organ-on-chip platforms are gaining importance in drug discovery, toxicity testing, diagnostics, and advanced biological research. However, widespread adoption remains constrained by the difficulty of connecting microscale devices to conventional fluid delivery hardware. Existing …
- College: College of Engineering (COE)
- Inventors: Agarwal, Shashwat; Jones, Travis; Song, Jonathan "Jon"
- Licensing Officer: Ashouripashaki, Mandana
Diffusion-Only Microfluidic Platform for Spatiotemporal Cell Signaling Analysis
TS-073289 —
Understanding how cells respond to soluble signals under diffusion-limited conditions remains a significant gap in current in vitro models. Most microfluidic systems rely on convective flow, which does not accurately reflect transport in interstitial tissue or solid tumors, where diffusion dominat…
- College: College of Engineering (COE)
- Inventors: Fuller, Brendan; Jones, Travis; Song, Jonathan "Jon"
- Licensing Officer: Ashouripashaki, Mandana
Modular Pumpless Perfusion System for Scalable Microfluidic Applications
TS-071982 — The Need
Current microfluidic systems for long-term perfusion rely heavily on syringe or peristaltic pumps, which are costly, bulky, and require external power and technical expertise. These limitations hinder scalability, accessibility, and usability, especially in resource-limited settings. There …
- College: College of Engineering (COE)
- Inventors: Agarwal, Shashwat; Fuller, Brendan; Holter, Jacob; Jones, Travis; Song, Jonathan "Jon"
- Licensing Officer: Ashouripashaki, Mandana
Novel Electrode for Co-factor Regeneration
TS-051995 — Method of regenerating NADPH for the production of biobutanol.
The Need
NAD(P)H is used as a reducing co-factor for the synthesis of biochemicals (e.g., conversion of aldehydes to alcohols) using biocatalysts or even microbes. Butanol is an important feedstock used in the chemical industry and shows great potential as a biofuel. Butanol is produced from fossil…
- College: College of Engineering (COE)
- Inventors: Kadowaki, Jonathan; Gopalan, Venkat; Jones, Travis; Sengupta, Anindita; Subramaniam, Vishwanath
- Licensing Officer: He, Panqing
Cancer Cell Motility Monitoring Device
TS-038384 — A novel device for monitoring cancer cell motility in real time using standard microscopy.
The Need
Numerous cancer cells are capable of migration, resulting in metastasis of distinct organs and tissues from where the cancer first arose. Migrating cancer cells are known to directionally respond to applied electric fields, a phenomenon called electrotaxis, as well as topological cues prov…
- College: College of Engineering (COE)
- Inventors: Garg, Ayush; Bushman, Sarah; Ferree, Jessica; Jones, Travis; Song, Jonathan "Jon"; Subramaniam, Vishwanath
- Licensing Officer: He, Panqing