# of Displayed Technologies: 10 / 19


Development of an E. coli strain for highthroughput screening of YidC inhibitors
TS-039359 — Development of a strain that is useful for screening compounds that inhibit YidC in E. coli and identification of compounds with antibacterial activity.
In bacteria, the YidC membrane protein functions in the insertation of proteins into the cytoplasmic membrane of E. coli. This protein is essential for life and is evolutionarily conserved. The rise of drug-resistant bacterial pathogens has created an urgent demand for novel antibiotic treatmen…
  • College: College of Arts & Sciences
  • Inventors: Dalbey, Ross
  • Licensing Officer: Paschall, Christopher

Oral cancer chemopreventive rinse
TS-037788 — Rinses with sustained contact time and field coverage have been developed to prevent oral cancer.
Oral cancer affects nearly 50,000 Americans each year and has a five year survival rate of 57%. Often, oral cancer is only discovered when it has metastasized, as it does not present recognizable symptoms, and it has a high risk of producing secondary tumors. Oral squamous cell carcinoma (OSCC), a…
  • College: College of Dentistry
  • Inventors: Mallery, Susan; Lahann, Joerg
  • Licensing Officer: Paschall, Christopher

Discovery of a novel CD34(+) natural killer precursor population in human lymph nodes
TS-037651 — Ohio State University researchers have discovered novel subset of human CD34 (+) hematopoietic precursor cells and generated a method of isolating them.
Natural killer (NK) cells are a type of lymphocyte that plays a role in the immune system. These cells can react against and destroy another cell without prior sensitization to it. The role of NK cells in tumor activity is known, but recent research has also linked them to other immune disease con…
  • College: College of Medicine (COM)
  • Inventors: Caligiuri, Michael; Becknell, Michael; Freud, Aharon
  • Licensing Officer: Paschall, Christopher

Novel Small-Molecule Integrin-linked Kinase/Phosphoinositide-dependent Protein Kinase-2 Inhibitors
TS-037647 — A novel set of molecules that inhibit integrin-linked kinase in order to suppress tumor cell growth and metastasis.
The Akt signaling pathway is responsible for apoptosis, cell proliferation, and metabolism. In tumor cells, this pathway is up-regulated and aids in promoting cancer cell survival. Complete activation of Akt pathway requires phosphorylation at two amino-acid residues, which are phosporylated by se…
  • College: College of Pharmacy
  • Inventors: Chen, Ching-Shih; Kulp, Samuel; Lee, Su-Lin
  • Licensing Officer: Paschall, Christopher

Combination Agent Approach for Improved Expansion and Mobilization of Hematopoietic Stem Cells
TS-037629 — Combined treatment of plerixafor and Flt3L better mobilize stem cells and do not exacerbate graft-versus-host disease following transplatation.
Hematopoietic stem cell transplantation (HSCT) is used in patients with hematologic malignancies resulting from irradiation and graft-versus-tumor effects. However, patients who undergone HSCT may suffer complications such as graft-versus-host disease (GVHD), infection, and relapse. The most commo…
  • College: College of Medicine (COM)
  • Inventors: Yu, Jianhua; Caligiuri, Michael; Devine, Steven
  • Licensing Officer: Paschall, Christopher

Autoscope - Otoscopy Image Analysis to Diagnose Ear Pathology
TS-037182 — An otoscopy device that overcomes inaccurate, subjective clinical diagnosis of ear disease by objectively detecting more than 14 eardrum abnormalities.
Misclassification of ear disease may result in clinical mismanagement in treatment. Unfortunately, diagnosis of ear pathology is highly subjective, and may require specialized training. There is a need for an objective mechanism to aid clinicians in more reliably diagnosing ear disease. Researc…
  • College: College of Medicine (COM)
  • Inventors: Gurcan, Metin; Elmaraghy, Charles; Essig, Garth "garth"; Moberly, Aaron; Senaras, Caglar; Taj-Schaal, Nazhat "Nazhi"; Teknos, Theodoros "Ted"; Yu, Lianbo
  • Licensing Officer: Paschall, Christopher

Ultrasonic Endodontic Dental Device
TS-037112 — A device for performing endodontic procedures such as root canals by utilizing ultrasonic energy to debride the root canal space
In Endodontics, research has shown that debridement, or removal of material from the root canal space, is of paramount importance for the success of a root canal to reduce the risk of infection and failure of the procedure. Traditional chemo-mechanical techniques using hand filing or contemporary …
  • College: College of Dentistry
  • Inventors: Nusstein, John
  • Licensing Officer: Paschall, Christopher

Non-Invasive Electromagnetic Method for Continuous Detection and Monitoring of Malaria
TS-015267 — An inexpensive device that utilizes non-invasive electromagnetic interactions with red blood cells to provide continuous monitoring for or diagnosis of malaria.
Plasmodium falciparum (PF), a form of malaria, is the deadliest and most prevalent parasite in humans due to its pervasiveness in temperate areas of the underdeveloped world. In 2013, there were nearly 198 million cases of malaria and an estimated 584,000 deaths, mostly among African children (BCC…
  • College: College of Engineering (COE)
  • Inventors: Subramaniam, Vishwanath; Drew, Mark; Smith, Brad; West, Joseph
  • Licensing Officer: Paschall, Christopher

Small-Molecule Cyclin D1 Ablative Agents for Breast Cancer Therapy
TS-015102 — A new class of small-molecule cyclin D1 ablative agents based on troglitazone (TG) that repress intracellular cyclin D1 levels.
Cyclin D1 represents an important downstream effector of diverse proliferative and transforming signaling pathways. In mammary cells, transcriptional activation of Cyclin D1 leads to G1/S phase progression and increased proliferation. Cyclin D1 overexpression has been implicated in oncogene-induce…
  • College: College of Pharmacy
  • Inventors: Chen, Ching-Shih; Huang, Jui-Wen
  • Licensing Officer: Paschall, Christopher

Novel Small-Molecule Protein Phosphatase 2A-Activating Agents
TS-015100 — Activation of protein phosphatase 2-A (PP2A) as a target for anticancer therapy with small molecules.
Previous work indicates that vitamin E succinate (VES) induces apoptosis in different types of cancers cells without significant toxicity to normal cells. Despite advances in the pre-clinical translation of VES in cancer therapy, the mechanisms underlying the effect of this redox-inactive vitamin …
  • College: College of Pharmacy
  • Inventors: Chen, Ching-Shih; Kulp, Samuel; Wang, Dasheng
  • Licensing Officer: Paschall, Christopher

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