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ReScribe: Transcription factors for reprogramming of diseased musculoskeletal related cells
TS-046978 — Transcription factors that can upregulate desired genes in diseased tissue to reprogram diseased cells, thereby reversing the disease and creating healthy non-diseased phenotype genes. These transcription factors would be especially useful in musculoskeletal diseases such as back pain and osteoarthritis.
Musculoskeletal diseases including osteoarthritis and chronic low back pain, are debilitating, painful, and often difficult to treat. Intervertebral disc (IVD) degeneration, as an example, is strongly associated with low back pain, a leading cause of disability worldwide. According to the American…
  • College: College of Engineering (COE)
  • Inventors: Walter, Devina; Gallego Perez, Daniel; Higuita Castro, Natalia; Hoyland, Judith; Khan, Safdar; Tang, Shirley "Shirley Nina"; Walter, Benjamin
  • Licensing Officer: Norris, Francis "Frank"

Novel selective protein purification via tangential flow filtration
TS-046780 — Dr. Andre Palmer’s lab at The Ohio State University has developed a novel purification method to isolate any target protein from a complex mixture. The process purifies a target protein (TP) from a mixture by exploiting molecular size changes that result from the formation of a protein complex consisting of a TP and its TP binding molecule (TPBM). This is accomplished via Tangential Flow Filtration (TFF). This process allows for simple and scalable purification of any protein, providing a wide range of applicability.
Proteins can be used in various medical and research applications including drug delivery, hemolysis therapies, and cancer therapies. However, purification of proteins from complex mixtures can require extensive process development. Current methods for protein purification rely on column chromatog…
  • College: College of Engineering (COE)
  • Inventors: Susin Pires, Ivan; Palmer, Andre
  • Licensing Officer: Davis, Stewart

FG10-313; Solanum lycopersicum L.; Tomato
TS-038123 — A new breed of the tomato plant.
FG10-313 is a tomato hybrid with high tetra-cis-lycopene due to a combination of naturally occurring mutations in the carotenoid isomerase (CRTISO) “tangerine” gene. FG10-313 needs a stronger effort than conventional tomatoes to market the unique characteristics of the tangerine hybrid. …
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Francis, David; Aldrich, Troy; Schwartz, Steven
  • Licensing Officer: Dahlman, Jason "Jay"

Battery consumption minimization strategy for plug-in, pure, and hybrid EVs
TS-036908 — An energy management strategy for pure and hybrid electric vehicles that improves battery-life and optimizes fuel economy
Automotive powertrains are increasingly more electric, from mild and full hybrid, to plug-in hybrid and battery electric, automotive propulsion is increasingly relying on electricity as a source of power assist, or as the sole source of power, in automotive vehicles. This is true for passenger, co…
  • College: College of Engineering (COE)
  • Inventors: Rizzoni, Giorgio; Tang, Li
  • Licensing Officer: Zinn, Ryan

FG04-168B tangerine tomato hybrid
TS-036701 — A tangerine tomato variety with anti-oxidative compounds that could help fight cancer
A tangerine tomato hybrid named FG04-168B that has high levels of tetra-cis-lycopene, comparable fruit yields, comparable sugar contents, and adequate agronomic characteristics compared to other tangerine tomato varieties and traditional red tomatoes. This specialty variety is suitable as a processi…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Francis, David
  • Licensing Officer: Dahlman, Jason "Jay"

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