TS-073138 — Designing online monitoring (OLM) for safety‑critical systems is constrained by scarce early‑stage operational data and by quantitative models that are slow to build, brittle across configurations, and costly to iterate. This creates expensive sensor networks with blind spots, poor diagnosabil…

TS-073103 — Physical protection remains a major driver of nuclear plant operations and maintenance costs, yet current security risk models rely on conservative assumptions and sparse empirical data on how defenders and operators actually behave under extreme threat. They rarely capture errors of commission, k…

TS-072175 — The Need Modern industrial and energy systems are increasingly complex, making timely fault detection and discrimination critical for safety, reliability, and cost control. Existing fault diagnosis methods often struggle with transient states, require extensive historical data, or lack interpretabil…

TS-063717 — The Need In the world of semiconductor material systems, the demand for advancements in optoelectronic and power electronic devices is ever-growing. The fabrication of semiconductor films, crucial for these applications, primarily relies on epitaxy technologies such as hydride vapor phase epitaxy (…

TS-063069 — In the wake of the global pandemic caused by SARS-CoV-2, the need for rapid, accurate, and efficient diagnostic methods for respiratory viral infections has become more critical than ever. Traditional diagnostic methods, while reliable, are often time-consuming, labor-intensive, and lack the neces…

TS-062682 — Glioblastoma (GBM) is the most common malignant brain tumor accounting for 47.7% of all brain cancers. Unfortunately, treatments are limited, and survival is poor, with approximately 40% living the first-year post-diagnosis and 17% in the second year. The Need Oncolytic viruses (OVs) are a prom…

TS-062679 — Glioblastoma (GBM) is the most common malignant brain tumor accounting for 47.7% of all brain cancers. Unfortunately, treatments are limited, and survival is poor, with approximately 40% living the first-year post-diagnosis and 17% in the second year. The Need Oncolytic viruses (OVs) are a prom…

TS-062213 — The Need: Preventing Respiratory Syncytial Virus (RSV) Infection and Disease Respiratory Syncytial Virus (RSV) is a highly prevalent and dangerous pathogen responsible for significant morbidity and mortality, particularly in infants, young children, and immunocompromised individuals. Despite its gl…

TS-049505 — An engineered base editor (iABE-NG) that uses an SpCas9 variant, a shortened adenine deaminase domain with eliminated RNA off-target activity, and an intein split for packaging into an adeno-associated virus (AAV), resulting in gene mutation correction.

TS-042856 — A Framework and Automatization process designed to determine the functionality of Embedded Digital Devices.