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A small-molecule USP30 inhibitor protects against doxorubicin-induced cardiomyopathy
TS-075254 — Problem Cardiomyopathy weakens the heart muscle and impairs its ability to pump blood effectively, often leading to heart failure or sudden cardiac death. While doxorubicin remains an essential component of many cancer regimens, its use is limited by the risk of causing lethal cardiomyopathy. A maj…
  • College: College of Medicine (COM)
  • Inventors: Sun, Nuo; Krigman, Judith; Yang, Mingchong; Zhang, Ruohan
  • Licensing Officer: Willson, Christopher

Small Molecule USP30 Inhibitors for the Treatment and Prevention of Cardiomyopathy
TS-066773 — The Need Cardiomyopathy, a disease of the heart muscle, poses significant public health challenges due to its diverse causes, symptoms, and potential complications, including heart failure and arrhythmias. With cardiomyopathy often induced by drugs, such as anthracyclines used in chemotherapy, ther…
  • College: College of Medicine (COM)
  • Inventors: Sun, Nuo; Krigman, Judith; Yang, Mingchong; Zhang, Ruohan
  • Licensing Officer: Willson, Christopher

SimulationAI -- AI-Enabled Software Solution for Physics-Based Simulations
TS-066058 — By adopting our AI-driven solution, engineering teams can achieve more in less time, push the boundaries of innovation, and significantly cut down costs, all while maintaining or increasing the reliability and accuracy of their structural and material analysis. This is not just an evolution in FEM technology—it's a revolution.
In an era where precision and efficiency drive the success of engineering projects, the finite element method (FEM) remains indispensable but is burdened by high operational and computational costs. These costs often lead to overlooked uncertainty factors, suboptimal designs, and significant finan…
  • College: College of Engineering (COE)
  • Inventors: Soghrati, Soheil; vemparala, Balavignesh; Yang, Ming
  • Licensing Officer: Giles, David

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