Small Molecule Modulators as a Means to Control Tomato Bacterial Canker

Small molecule modulators of Clavibacter michiganensis subsp. michiganensis (Cmm) as a means to control tomatobacterial canker.

The Need: Revolutionizing Plant Disease Management

Plant diseases caused by Clavibacter michiganensis subspecies, particularly bacterial canker in tomatoes, pose significant challenges to the agriculture industry. Conventional methods of control, such as clean seed usage and chemical treatments, have proven to be limited and unsustainable. The urgent need for a novel approach to combat these devastating plant diseases has become apparent. As the economic losses and yield reductions continue to impact both commercial fields and controlled studies, there is a demand for innovative technologies that can effectively manage and mitigate Clavibacter michiganensis infections.

The Technology: Modulators of Clavibacter michiganensis

Our groundbreaking technology introduces modulators specifically designed to target Clavibacter michiganensis and its subspecies. These unique compounds are formulated to combat the pathogen and effectively treat diseases like bacterial canker in plants. The technology also includes derivatives of these modulators, enhancing their potency and effectiveness.

Commercial Applications:

  • Management of Tomato Bacterial Canker: Our technology's primary application is to manage and control bacterial canker in tomato crops. By treating seeds with the modulators, we can significantly reduce the transmission and spread of Clavibacter michiganensis, leading to healthier plants and higher yields.

  • Addressing Clavibacter michiganensis in Other Crops: Our technology's versatility extends beyond tomatoes, offering effective solutions for other economically important plants affected by various Clavibacter michiganensis subspecies. These include maize, beans, potatoes, wheat, and alfalfa.

  • Improved Crop Rotation Practices: By incorporating our modulators into crop rotation strategies, farmers can enhance disease management and minimize the risk of Clavibacter michiganensis infections in their fields.


  • Enhanced Disease Control: Our modulators offer a novel mechanism of action, allowing for more effective control of Clavibacter michiganensis infections compared to traditional chemical treatments, which often suffer from limited efficacy and the development of bactericide resistance.

  • Sustainable Agriculture: By reducing the reliance on copper-based bactericides and antibiotics, our technology promotes environmentally friendly agricultural practices while ensuring optimal crop health.

  • Increased Yield and Profitability: With bacterial canker and other Clavibacter michiganensis subspecies under control, farmers can expect a significant increase in yield and overall profitability of their agricultural operations.

  • Improved Seed Quality: The treatment and coating of seeds with our modulators ensure that the primary source of inoculum for Clavibacter michiganensis is eliminated, safeguarding the health and productivity of future plant generations.

  • Versatile Application: The technology's adaptability to multiple crops widens its potential impact on diverse agricultural sectors, providing solutions to various disease challenges.

Embrace the future of plant disease management with our revolutionary technology, designed to protect crops, optimize yields, and drive sustainable agriculture. Together, we can build a healthier, more resilient farming industry, safeguarding the global food supply for generations to come.


Patent # Title Country
9,896,450 Modulators of Clavibacter Michiganensis and Methods of Making and Using Thereof United States of America

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