The Need

Lymphoma is the most common life-threatening cancer of dogs, accounting for up to 24% of all malignancies and over 80% of all hematopoietic cancers. Spontaneously occurring lymphoma in the dog has many of the same histopathological, molecular, and clinical features as non-Hodgkin’s lymphoma (NHL) in people as well. Likewise, spontaneous lymphoma in the dog has a similar clinical presentation, response to chemotherapy, and clinical progression compared to NHL in people. Given these similarities and the advantage of larger subject size and presence of spontaneous disease (in contrast to small subject size and experimentally induced disease in rodents); spontaneously occurring lymphoma in the dog represents an excellent large animal model for the study of lymphoma in people, including investigation of new therapeutic agents. Few canine leukemia/lymphoma cell lines have been established, and most existing cell lines are derived from leukemias rather than lymphomas, or have an otherwise uncertain origin. Furthermore, most of these other cell lines are insufficiently characterized and often are not available to the general scientific community for use for a variety of reasons..

The Technology

The Ohio State University researchers, led by Dr. William Kisseberth, have developed a canine lymphoma cell line established from the malignant pleural effusion of a dog with peripheral T-cell lymphoma. The cell line is the best characterized as established canine lymphoma cell line and contains several of the common chromosomal aberrations found in canine lymphoma. Thus, at the genetic level it is reasonably representative of the canine disease. This novel cell line can be utilized in lymphoma tumor biology studies, preclinical and translational drug development, and comparative and translational lymphoma research.

Commercial Applications

• Lymphoma tumor biology studies
• Preclinical and translational drug development
• Comparative and translational lymphoma research

Benefits/Advantages

• Cell line is the best characterized established canine lymphoma cell line
• Contains several of the common chromosomal aberrations found in canine lymphoma
• Clearly lymphoma derived and representative of lymphoma
• Grows rapidly in vitro