The Need

A recent study has shown that over 6.3 million fractures occur in the United States every year, while more than 36 million people have arthritis. One of the methods to help treat this is with bone-tissue engineering, using materials such as poly(lactic acis), poly(glycolic acid), and other forms of polymers. Of these polymers, the one that is most commonly used is poly(propylene fumarate) (PPF). However, the current method to synthesize PPF requires a large amount of energy, and takes a very long time to complete. Therefore, a new way to create PPF is essential for the financial stability of the patients.

The Technology

Researchers at The Ohio State University, led by Dr. David Dean, created a new way to make PPF that is efficient, takes less time, and does not cost as much. Their method is to use the ring opening synthesis technique with a very low polydispersity index. The researchers also attached functionally significant amino acid sequences on the surface of the PPF, which was accomplished by using the alkylating method.

Commercial Applications

• Hospitals
• Bone repair methodology

Benefits/Advantages

• This method allows for altering the properties of PPF, like strength, stiffness, and material property alignment
• This method uses less energy and time to complete
• This method is scalable for small and large production