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Novel Extracellular Vesicles Loaded with Anti-Inflammatory Agents
TS-065154 — Revolutionary treatment for ARDS using novel extracellular vesicles loaded with Anti-Inflammatory Agents.
The Need Acute Respiratory Distress Syndrome (ARDS) remains a significant healthcare challenge with high mortality rates and long-term morbidity. Despite advancements in supportive care, there’s an urgent need for pharmacologic treatments targeting the molecular mechanisms driving ARDS pathog…
  • College: College of Medicine (COM)
  • Inventors: Karpurapu, Manjula; Christman, John; Parinandi, Narasimham
  • Licensing Officer: Schultz, Teri

Combination B Cell Epitope Vaccines for Cancer Treatment
TS-064843 — , T2022-244, T2020-109 : Cancer vaccines targeting a combination of B Cell epitopes to improve patient outcomes.
The Need Despite the clinical success of checkpoint receptor blockade in various cancer subtypes, many patients develop resistance, presenting a pressing need for novel approaches. Current inhibitors, like PD-1/PD-L1 and HER-2 exhibit limited efficacy and significant toxicities, underscoring the d…
  • College: College of Medicine (COM)
  • Inventors: Kaumaya, Pravin
  • Licensing Officer: Schultz, Teri

Buckeye Paws: Transforming Mental Health with Innovative Therapy Dog Intervention
TS-064833 — The Need: In today's high-stress environments, maintaining mental and emotional well-being is paramount for employees and students alike. Buckeye Paws addresses this crucial need by offering a unique therapy dog intervention designed to promote comfort, happiness, and resilience within The Ohio …
  • College: College of Medicine (COM)
  • Inventors: Steinberg, Beth; Justice, Mary; Mitchell, Aimee
  • Licensing Officer: Wilburn, Adri

Innovative Solutions for Acute Myeloid Leukemia: The Role of EGFL7
TS-064071 — EGFL7-centric technology for diagnosis, prognosis, and therapeutic strategies for hematologic malignancies.
The complex genetic landscape of Acute Myeloid Leukemia (AML), marked by chromosomal alterations and gene mutations, necessitates innovative approaches. The Need AML poses a significant challenge in the realm of hematologic malignancies, demanding both prognostic markers and novel treatments. Curr…
  • College: College of Medicine (COM)
  • Inventors: Dorrance, Adrienne; Garzon, Ramiro; Shen, Changxian
  • Licensing Officer: Schultz, Teri

Novel STK1-targeted small molecule "antibiotic resistance breaker" compounds
TS-063547 — Novel small molecule STK1 inhibitors that “break” the resistance of bacteria strains to antibiotics.
In today’s healthcare landscape, increasingly highly pathogenic and multidrug-resistant S. aureus (MDRSA) strains are replacing traditional methicillin-resistant S. aureus (MRSA) in both community and hospital settings. The Need The rise of these resilient multi-drug resistant bacteria has …
  • College: College of Medicine (COM)
  • Inventors: Pancholi, Vijay
  • Licensing Officer: Schultz, Teri

Hybrid Collaborative Filtering Methods for Recommending Search Terms to Clinicians
TS-063237 — Electronic Health Records (EHR) are used in over 88% of all US medical clinics to improve care and streamline data. In addition, they enable sharing of data to multiple providers dealing with the same patient, thereby enhancing efficiency and care. The Need In the last decade, medical practices…
  • College: College of Medicine (COM)
  • Inventors: Ning, Xia; Peng, Bo; Ren, Zhiyun
  • Licensing Officer: Hampton, Andrew

Patient Access Prioritization Score
TS-063212 — When a patient demonstrates signs of imminent clinical deterioration, it is essential to immediately assess and treat the patient to prevent intensive care unit transfer, cardiac arrest, or death. These tasks often include transferring the patient to other facilities with optimal capabilities. T…
  • College: College of Medicine (COM)
  • Inventors: Reinbolt, Raquel; Cohn, David
  • Licensing Officer: Hampton, Andrew

Force Plate Surface Calibration Device
TS-063194 — The Need In the medical and healthcare arena, force plate technology is frequently relied upon for evaluating a patient’s ability to meet normal human standards when performing different physical activities and determining the presence of limitations in mechanistic-type behaviors due to age, …
  • College: College of Medicine (COM)
  • Inventors: Onate, James; Caccese, Jaclyn; Edwards, Nathan; Hagen, Joshua; Kang, Yun Seok
  • Licensing Officer: Hampton, Andrew

Gene Therapy Compositions for Treating Cardiovascular Diseases
TS-063091 — A gene therapy approach to address the specific needs of failing hearts.
Heart failure affects over 6 million adults in the US and can lead to irreversible damage to the heart. The Need In the realm of cardiovascular health and the management of heart-related disorders, there exists a pressing commercial need for a technology that can effectively address the challenge…
  • College: College of Medicine (COM)
  • Inventors: Lewandowski, E. Douglas; Carley, Andrew
  • Licensing Officer: Schultz, Teri

Method for Prediction of Artificial Intelligence Model Generalizability for Unseen Data
TS-063039 — Medical-based AI systems have seen increased use in recent years across a range of applications (e.g., diagnostics, prognostics, treatment response prediction). Their widespread adoption by the medical community is still restricted, primarily due to their limited ability to realize a high degree of
  • College: College of Medicine (COM)
  • Inventors: Dikici, Engin; Nguyen, Xuan; Prevedello, Luciano
  • Licensing Officer: Hampton, Andrew

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