Novel Extracellular Vesicles Loaded with Anti-Inflammatory Agents
TS-065154 — Revolutionary treatment for ARDS using novel extracellular vesicles loaded with Anti-Inflammatory Agents.
The Need
Acute Respiratory Distress Syndrome (ARDS) remains a significant healthcare challenge with high mortality rates and long-term morbidity. Despite advancements in supportive care, there’s an urgent need for pharmacologic treatments targeting the molecular mechanisms driving ARDS pathog…
- College: College
of
Medicine
(COM)
- Inventors: Karpurapu, Manjula; Christman, John; Parinandi, Narasimham
- Licensing Officer: Schultz, Teri
Combination B Cell Epitope Vaccines for Cancer Treatment
TS-064843 — , T2022-244, T2020-109 : Cancer vaccines targeting a combination
of B Cell epitopes to improve patient outcomes.
The Need
Despite the clinical success of checkpoint receptor blockade in various cancer subtypes, many patients develop resistance, presenting a pressing need for novel approaches. Current inhibitors, like PD-1/PD-L1 and HER-2 exhibit limited efficacy and significant toxicities, underscoring the d…
- College: College
of
Medicine
(COM)
- Inventors: Kaumaya, Pravin
- Licensing Officer: Schultz, Teri
Buckeye Paws: Transforming Mental Health with Innovative Therapy Dog Intervention
TS-064833 — The Need: In today's high-stress environments, maintaining mental and emotional well-being is paramount for employees and students alike. Buckeye Paws addresses this crucial need by offering a unique therapy dog intervention designed to promote comfort, happiness, and resilience within The Ohio …
- College: College
of
Medicine
(COM)
- Inventors: Steinberg, Beth; Justice, Mary; Mitchell, Aimee
- Licensing Officer: Wilburn, Adri
Innovative Solutions for Acute Myeloid Leukemia: The Role of EGFL7
TS-064071 — EGFL7-centric technology for diagnosis, prognosis, and therapeutic strategies for hematologic malignancies.
The complex genetic landscape of Acute Myeloid Leukemia (AML), marked by chromosomal alterations and gene mutations, necessitates innovative approaches.
The Need
AML poses a significant challenge in the realm of hematologic malignancies, demanding both prognostic markers and novel treatments. Curr…
- College: College
of
Medicine
(COM)
- Inventors: Dorrance, Adrienne; Garzon, Ramiro; Shen, Changxian
- Licensing Officer: Schultz, Teri
Novel STK1-targeted small molecule "antibiotic resistance breaker" compounds
TS-063547 — Novel small molecule STK1 inhibitors that “break” the resistance
of bacteria strains to antibiotics.
In today’s healthcare landscape, increasingly highly pathogenic and multidrug-resistant S. aureus (MDRSA) strains are replacing traditional methicillin-resistant S. aureus (MRSA) in both community and hospital settings.
The Need
The rise of these resilient multi-drug resistant bacteria has …
- College: College
of
Medicine
(COM)
- Inventors: Pancholi, Vijay
- Licensing Officer: Schultz, Teri
Hybrid Collaborative Filtering Methods for Recommending Search Terms to Clinicians
TS-063237 — Electronic Health Records (EHR) are used in over 88% of all US medical clinics to improve care and streamline data. In addition, they enable sharing of data to multiple providers dealing with the same patient, thereby enhancing efficiency and care.
The Need
In the last decade, medical practices…
- College: College
of
Medicine
(COM)
- Inventors: Ning, Xia; Peng, Bo; Ren, Zhiyun
- Licensing Officer: Hampton, Andrew
Patient Access Prioritization Score
TS-063212 — When a patient demonstrates signs of imminent clinical deterioration, it is essential to immediately assess and treat the patient to prevent intensive care unit transfer, cardiac arrest, or death. These tasks often include transferring the patient to other facilities with optimal capabilities.
T…
- College: College
of
Medicine
(COM)
- Inventors: Reinbolt, Raquel; Cohn, David
- Licensing Officer: Hampton, Andrew
Force Plate Surface Calibration Device
TS-063194 — The Need
In the medical and healthcare arena, force plate technology is frequently relied upon for evaluating a patient’s ability to meet normal human standards when performing different physical activities and determining the presence of limitations in mechanistic-type behaviors due to age, …
- College: College
of
Medicine
(COM)
- Inventors: Onate, James; Caccese, Jaclyn; Edwards, Nathan; Hagen, Joshua; Kang, Yun Seok
- Licensing Officer: Hampton, Andrew
Gene Therapy Compositions for Treating Cardiovascular Diseases
TS-063091 — A gene therapy approach to address the specific needs
of failing hearts.
Heart failure affects over 6 million adults in the US and can lead to irreversible damage to the heart.
The Need
In the realm of cardiovascular health and the management of heart-related disorders, there exists a pressing commercial need for a technology that can effectively address the challenge…
- College: College
of
Medicine
(COM)
- Inventors: Lewandowski, E. Douglas; Carley, Andrew
- Licensing Officer: Schultz, Teri
Method for Prediction of Artificial Intelligence Model Generalizability for Unseen Data
TS-063039 — Medical-based AI systems have seen increased use in recent years across a range of applications (e.g., diagnostics, prognostics, treatment response prediction). Their widespread adoption by the medical community is still restricted, primarily due to their limited ability to realize a high degree of …
- College: College
of
Medicine
(COM)
- Inventors: Dikici, Engin; Nguyen, Xuan; Prevedello, Luciano
- Licensing Officer: Hampton, Andrew
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