Method and Apparatus for Contained-Electrospray for Use in Mass Spectrometry and Droplet Reactions

The Need:

In today's analytical landscape, there is a pressing demand for improved sensitivity in electrospray ionization (ESI) to accurately quantify diverse analytes within complex mixtures. However, this task is often hindered by varying ionization responses among different compounds, including polar, non-polar, and ammonium cations, leading to significant suppression effects among the analytes. Consequently, the mass spectrum derived from such mixtures typically only captures surface-active analytes. Addressing these challenges and catering to the need for enhanced sensitivity and precise analysis, we introduce our revolutionary technology.

The Technology:

Our technology presents a breakthrough in ESI, offering advanced apparatuses designed to significantly enhance sensitivity and accuracy in analyzing complex mixtures. The system comprises an electrospray emitter, featuring a sample capillary extending from a sample inlet to a sample outlet, along with a voltage source conductively coupled to the sample capillary to apply a voltage, typically ranging from 4 kV to 5 kV. The sample capillary is expertly crafted using fused silica to ensure optimal performance.

Furthermore, the apparatus encompasses an element incorporating a conduit coaxially placed around the electrospray emitter, forming a chamber that extends between the conduit and the sample capillary, ultimately terminating in a gas outlet. To ensure seamless functionality, the chamber includes a carrier gas inlet and a working gas inlet, providing a fluid flow path from the carrier gas inlet and the working gas inlet to the gas outlet. The element is also equipped with an auxiliary gas inlet, further enhancing the system's capabilities.

Commercial Applications:

The technology's unparalleled sensitivity and quantitative accuracy open doors to a wide range of commercial applications, including but not limited to:

  • Pharmaceutical Research and Development: Precise analysis of complex drug formulations and biological samples, enabling efficient drug discovery and development processes.
  • Environmental Monitoring: Accurate quantification of pollutants and contaminants in environmental samples for better assessment and management of environmental health.
  • Food and Beverage Industry: Quality control and authentication of food products by detecting and quantifying specific compounds within complex matrices.

Benefits/Advantages:

Our cutting-edge technology offers numerous benefits and advantages, positioning it as the preferred choice for analytical needs:

  • Enhanced Sensitivity: Significantly improved sensitivity allows for the detection and quantification of even trace amounts of analytes in complex mixtures.
  • Quantitative Precision: The technology ensures accurate and reliable quantitative analysis, minimizing errors and enhancing data integrity.
  • Versatile Performance: The system is adaptable to a variety of applications, making it a versatile and indispensable tool in diverse industries.

Stay ahead of the competition and revolutionize your analytical capabilities with our groundbreaking technology. Experience unparalleled sensitivity, precision, and versatility for all your complex mixture analyses.

Patents

Patent # Title Country
9852896 Method and Apparatus for Contained Electrospray for Use in Mass Spectrometry and Droplet Reactions United States of America
9852896 Method and Apparatus for Contained Electrospray for Use in Mass Spectrometry and Droplet Reactions United States of America
9852896 Method and Apparatus for Contained Electrospray for Use in Mass Spectrometry and Droplet Reactions United States of America

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