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Design and apparatus for quantification of the mapping of the sensory areas of the brain
TS-039164 — A new tool that can quantify the sensory maps of the human brain. The tool can be used to quantify plasticity and pathology in the sensory areas of the human brain that are associated with normal and abnormal development, aging, and diseases in sensory systems. The first application of the tool, on retinotopic maps of the visual cortex, has generated excellent results.
By analyzing the stimulus­-referred fMRI responses in each voxel of an MR image, retinotopic mapping of human visual cortex can generate cortical maps of the visual space. These maps elucidate the spatial organization of the neuronal responses to visual images. Although numerous studies have b…
  • College: College of Arts & Sciences
  • Inventors: Wang, Yalin; Lu, Zhong-Lin; Ta, Duyan
  • Licensing Officer: Norris, Francis "Frank"

Absolute Minimal Sampling of Homonuclear 2D NMR TOCSY Spectra for High-Throughput Applications of Complex Mixtures
TS-037865 — A technique to increase the processing speed of data collection without losing accuracy
Modern applications of 2D NMR spectroscopy for diagnostic screening, metabolomics, quality control, and other high-throughput applications are limited by the time-consuming sampling requirements. 2D Total Correlation Spectroscopy (TOCSY) provides unique spin connectivity information for the analys…
  • College: College of Arts & Sciences
  • Inventors: Bruschweiler, Rafael; Hansen, Alexandar "Alex"; Li, Dawei "Dawei"
  • Licensing Officer: Wohlgamuth, Christopher

A Novel Microbial Therapeutic to Diminish the Risk of Arteriosclerosis and Subsequent Heart Disease
TS-037792 — Novel bacteria, specially formatted, could be utilized as a microbial therapeutic for diminishing the risk of arteriosclerosis and subsequent heart disease.
Cardiovascular disease is the leading cause of mortality in the United States. Evidence is accumulating that certain human intestinal microbes contribute to atherosclerosis leading to cardiovascular disease, thereby increasing the risk of heart attack, stroke, and death. Gut microbes convert quate…
  • College: College of Arts & Sciences
  • Inventors: Krzycki, Joseph; Ferguson, Donald; Kountz, Duncan
  • Licensing Officer: Rumpal, Nidhi

Immobilization of Biomolecules (Rubisco) by Self-Assembled Nanostructures
TS-037787 — Nanostructures that enhance the stability of biocatalysts that permit them to be utilized in scalable CO2 conversion processes
Carbon dioxide (CO2) and methane (CH4) are the two most abundant greenhouse gasses, trapping thermal radiation close to the earth's atmosphere and contributing to climate change. These two gasses contributed up to 92% of all the greenhouse gas emissions in 2015 (epa.gov). From an industrial pe…
  • College: College of Arts & Sciences
  • Inventors: Parquette, Jonathan; Satagopan, Sriram; Sun, Yuan; Tabita, Fred
  • Licensing Officer: Flammang, Ann Marie

Method for mass production of seleno-cysteine containing proteins from transgenic algae
TS-037670 — Production of selenocysteine using transgenic algae to create industrial sized yields.
The possibility to introduce the amino acid selenocysteine (Sec) residue into proteins may be of substantial importance for several different applications beyond facilitating studies of natural selenoproteins. These include specific radiolabeling, PET studies, x-ray crystallography, NMR, protein f…
  • College: College of Arts & Sciences
  • Inventors: Sayre, Richard
  • Licensing Officer: Dahlman, Jason "Jay"

Microalgal Based Animal Feed Supplements
TS-037624 — A method of delivering chromium, copper, zinc, manganese, and selenium to cattle through transgenic algae.
Dairy cattle serve an important function in the diet of humans worldwide. However, when these cattle are not fed a balanced diet, they can suffer increases in morbidity during transportation, a weakened immune system, and a decrease in milk production. One method of balancing the feed is by includ…
  • College: College of Arts & Sciences
  • Inventors: Sayre, Richard; Wagner, Richard
  • Licensing Officer: Dahlman, Jason "Jay"

Design and apparatus for efficient measurement of the time course of perceptual sensitivity change
TS-037470 — A novel method of measuring the time course of degradation of perceptual sensitivity due to disease
Perception is the biological process that allows humans to differentiate external stimuli such as shapes and colors. Certain diseases affect perceptual sensitivity, usually resulting in a slow but measurable degrade in skill that correlates with the progression of the disease. Existing methods to …
  • College: College of Arts & Sciences
  • Inventors: Lu, Zhong-Lin; Lesmes, Luis; Zhao, Yukai
  • Licensing Officer: Norris, Francis "Frank"

CO2 Reduction to Acetate on Mixed Metal Oxide Catalyst
TS-037385 — A process for photoelectrochemical reduction of carbon dioxide to acetate using mixed metal oxide as catalysts
The combustion of fossil fuels produces billions of tons of carbon dioxide annually. Research indicates that greater concentrations of carbon dioxide in the atmosphere has altered Earth's climate, changed the pH of the ocean, and causing other potentially damaging evironmental effects. Countri…
  • College: College of Arts & Sciences
  • Inventors: Baker, Lawrence "Robert"; Yang, Xin
  • Licensing Officer: Wohlgamuth, Christopher

Aza-Peptide Ketones, A Novel Class Of Reversible Protease Inhibitors
TS-037264 — Novel aza-peptide ketone reversible protease inhibitors, which permit more drug-like and selective activity than current irreversible aza-peptide containing inhibitors.
Current protease inhibitors cause severe side effects arising from nonspecific activity of the leading drugs. For the current major drugs on the market and in clinical trials for treatment of multiple myeloma, for instance, these off-target effects result in peripheral neuropathies. There is a nee…
  • College: College of Arts & Sciences
  • Inventors: Dogan Ekici, Ozlem; Corrigan, Thomas; Hadad, Christopher
  • Licensing Officer: Paschall, Christopher

Novel Anaerobic Microbial Process to Synthesize Ethylene
TS-036545 — Methionine salvaging is a totally anaerobic (oxygen deficient) process by which large amounts of ethylene are made as a result of manipulating bacterial metabolism in select microorganisms.
Ethylene (C2H4) is used in a variety of industrial processes, including the production of polyethylene for plastic bags, polystyrene for packaging and insulation, and ethylene oxide for detergents. Manufacturing of ethylene is done today through the thermal cracking of either naphtha (an oil deriv…
  • College: College of Arts & Sciences
  • Inventors: Tabita, Fred; Miller, Anthony; North, Justin; Young, Sarah
  • Licensing Officer: Rumpal, Nidhi

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