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Method to improve efficiency and specificity of human tumor targeting and elimination by using a combination of split & splice protein toxins and oncolytic viruses

TS-040838 — Novel strategy to improve efficiency and specificity of tumor treatment via combinative use of a split & splice protein toxin and oncolytic virus.

In combating malignancies as complex as cancer, researchers and clinicians have created a diverse set of strategies to reduce tumor burden. Oncolytic viruses (OVs) have emerged as a promising means of treating this disease due to their potential to selectively target and effectively kill cancer ce…

College: College of Arts & Sciences
Inventors: Kudryashov, Dmitri; Kudryashova, Elena
Licensing Officer: Flammang, Ann Marie

Ultra-Fast Charging Li-ion Battery Anodes

TS-040614 — A novel battery anode designed to overcome the limitations posed on fast charge batteries by graphite anodes. The new anode increases battery life, is more stable during manufacturing, and has improved heat dissipation qualities.

As technology continues to progress, embedding itself in our daily life from our cars to our wrists, an ever-present concern is the need for batteries with the ability to re-charge quickly. Most of these emerging technologies use Li-ion batteries with graphite anodes. Unfortunately, under fast cha…

College: College of Arts & Sciences
Inventors: Co, Anne; Bascaran, Julen
Licensing Officer: Gooray, Arthur "Art"

The STEMcoding Learning Management System

TS-040123 — The STEMcoding Learning Management System is a tool for incorporating computer programming activities into introductory STEM courses.

As technology becomes more advanced over time, the need for people with programming knowledge increases, especially in fields where technology can be used to improve efficiency. Despite the fact that STEM courses have not traditionally used programming activities to teach concepts, there are vast …

College: College of Arts & Sciences
Inventors: Orban, Christopher; Britt, Christopher "Christopher"; Porter, Christopher
Licensing Officer: Smith, Richard

Synthetic apratoxins and novel analogs for anticancer and therapeutic applications

TS-039269 — Synthetic natural apratoxins and non-natural apratoxin analogs with improved pharmacokinetic profiles for cancer treatments and drug development applications.

Apratoxins are potent cytotoxic biosynthetic products that are naturally produced by specific marine microorganisms. When isolated from organisms, the compounds display very potent anticancer activities. In addition, they have been implicated in immunosuppressive activity. However, in their natura…

College: College of Arts & Sciences
Inventors: Forsyth, Craig; Jackel, Matthew; Li, Xiao
Licensing Officer: Paschall, Christopher

Design and apparatus for quantification of the mapping of the sensory areas of the brain

TS-039164 — A new tool that can quantify the sensory maps of the human brain. The tool can be used to quantify plasticity and pathology in the sensory areas of the human brain that are associated with normal and abnormal development, aging, and diseases in sensory systems. The first application of the tool, on retinotopic maps of the visual cortex, has generated excellent results.

By analyzing the stimulus-referred fMRI responses in each voxel of an MR image, retinotopic mapping of human visual cortex can generate cortical maps of the visual space. These maps elucidate the spatial organization of the neuronal responses to visual images. Although numerous studies have b…

College: College of Arts & Sciences
Inventors: Wang, Yalin; Lu, Zhong-Lin; Ta, Duyan
Licensing Officer: Norris, Francis "Frank"

Paper-based Dried Blood Spheroids for Stabilization of Labile Organic Compounds Stored in Ambient Air

TS-038604 — Apparatus and methods to form three-dimensional dried blood spheroids on hydrophobic paper substrates.

Dried blood spots on paper substrates offer a facile sample collection, storage, and transportation approach for biofluids. However, variable diffusion, volcanic effects, analyte instability, and difficulty in recovering samples from paper plague this method, lowering confidence in analyte quantif…

College: College of Arts & Sciences
Inventors: Badu-Tawiah, Abraham; Damon, Deidre
Licensing Officer: Smith, Richard

Method for treatment of diseases of central nervous system (CNS) and improvement of cognitive function by nanoscaffolds

TS-038406 — A novel method to improve CNS metabolism and overall cognitive function as well as reduce peripheral neurodeneration, through the use of nanomatrices with or without identified redefined delivery biologicals and/or insulin.

The central nervous system (CNS) can be implicated in a broad category of diseases in which the brain does not function as expected. Conditions may result from a metabolic disorder; damage from an infection, a degenerative condition, stroke, a brain tumor or other problem; or arise from unknown or…

College: College of Arts & Sciences
Inventors: Ziouzenkova, Ouliana; Parquette, Jonathan
Licensing Officer: Flammang, Ann Marie

GeoGame: Online Map Game for Teaching and Learning through a Real-World Spatial Perspective

TS-038064 — A novel platform that incorporates geographical mapping and satellite images for an interactive, educational game-play environment.

Many educators lament the lack of available resources in the classroom due to limited technology, limited access, insufficient time, or inadequate technical support. Currently, there are both hardware and software barriers that restrict access for many students and schools. Experts have expressed …

College: College of Arts & Sciences
Inventors: Ahlqvist, Karl "Ola"; Heckler, Andrew; Ramnath, Rajiv
Licensing Officer: Smith, Richard

Scalable solution-phase routes to carbides

TS-038007 — A method for synthesizing a broad class of metal carbide materials.

Select early-transition metal carbides have significant catalytic and electrocatalytic applications, including fuel cell reactions and biomass conversion. The hydrogen-transfer reaction rates of these carbides is comparable to expensive, less abundant materials. Therefore, the preparation of monod…

College: College of Arts & Sciences
Inventors: Goldberger, Joshua; Baum, Zachary
Licensing Officer: Wohlgamuth, Christopher

Development of Non-Foaming High Strength, Single Component Methacrylate/Polyurethane Adhesive

TS-037956 — A single component, moisture-cured methacrylate/polyurethane hybrid adhesive that combines the non-toxic, high strength properties of methacrylate adhesives with the bonding characteristics of polyurethanes

Methacrylate adhesives are strong and can be used on similar or dissimilar materials, such as plastic, metal, composites, and ceramic. They have excellent peel strength, resist abrasion, and stand up to a fair range of temperatures. They also require little preparation of the surfaces to be bonded…

College: College of Arts & Sciences
Inventors: Parquette, Jonathan; Bewick, Nicholas; Schricker, Scott
Licensing Officer: Dahlman, Jason "Jay"

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