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Reservoir Simulations Tools to Inform Natural Hydrogen Exploration and Production Strategies
TS-054822 — Naturally occurring hydrogen is found in subsurface formations. Successful exploration for subsurface resources requires a systematic understanding of the occurrence and evolution of the resource within various geologic environments. Evolution of the modeling capabilities of previously developed p…
  • College: College of Arts & Sciences
  • Inventors: Moortgat, Joachim; Darrah, Thomas
  • Licensing Officer: Sita, Cordellia

Machine Learning Techniques for the Identification of Geomorphological Features to Identify Subsurface Natural Hydrogen Reservoirs
TS-054820 — Naturally occurring hydrogen is found in subsurface formations. Successful exploration for subsurface resources requires a systematic understanding of the occurrence and evolution of the resource within various geologic environments. Remote sensing (acquiring, processing, and interpreting images a…
  • College: College of Arts & Sciences
  • Inventors: Darrah, Thomas; Howat, Ian; Moortgat, Joachim; Whyte, Colin
  • Licensing Officer: Hong, Dongsung

Method for controlling multiple heterogenous magnetic bacteria at a solid-liquid interface using uniform magnetic fields
TS-053222 — Manipulatable miniaturized robots have a variety of applications in biomedical sciences, specifically microrobots capable of navigating in vivo blood vessels have the potential to revolutionize non-invasive surgery and targeted drug delivery for cancer and other disease treatment. Drug discovery c…
  • College: College of Arts & Sciences
  • Inventors: Wijesinghe, Hiran
  • Licensing Officer: Hong, Dongsung

Activation of human Argonaute3 (AGO3) using cityRNAs
TS-051298 — MicroRNAs (miRNAs) are small non-coding RNAs that control gene expression post-transcriptionally. Their sequences differ, but their lengths fall within a range of ~20-23 nucleotides because the precursor miRNAs are processed by Dicer. Dicer cleaves long double-stranded RNA (dsRNA) molecules into s…
  • College: College of Arts & Sciences
  • Inventors: Nakanishi, Kotaro; Park, Mi Seul
  • Licensing Officer: Willson, Christopher

Mini-PCDH15 for treatment of deafness
TS-050433 — A gene therapy solution for Usher Syndrome Type 1F.
Mutations in PCDH15 cause Usher 1F, a recessive syndrome characterized by profound congenital deafness and absence of vestibular function, and progressive blindness beginning in the second decade. Because patients who lack hearing and balance rely on vision for communication and mobility, the late…
  • College: College of Arts & Sciences
  • Inventors: Sotomayor, Marcos
  • Licensing Officer: Dahlman, Jason "Jay"

Redox Relay Flow Batteries: hybrid systems for scalable, high-capacity batteries.
TS-050105 — This application relates generally to a novel redox relay flow batteries comprising redox-active solids configured to behave as storage materials and redox-active organic molecules configured to behave as energy shuttles.
The Need The growing global demand for electrical energy has increased research efforts towards the integration of renewable energy sources into the electrical grid. Generation of energy from petroleum-based sources dominates the current market, but dependence on renewable energy is expected to gro…
  • College: College of Arts & Sciences
  • Inventors: Sevov, Christo; Wong, Curt
  • Licensing Officer: Sita, Cordellia

Stealth liposomes with greater stability for improved drug delivery
TS-048888 — Liposome drug delivery systems play a significant role in the formulation of new therapies. These liposome-encapsulated drugs are used to treat a wide range of diseases such as cancer, influenza, and hepatitis. While endogenous liposomes are recognized by the mononuclear phagocyte system and clear…
  • College: College of Arts & Sciences
  • Inventors: Bong, Dennis
  • Licensing Officer: Willson, Christopher

Electrophiles for Re-activation of Aged Acetylcholine Esterase
TS-044619 — Organophosphorus (OP) poisons including sarin, VX, and novichoks are lethal agents of chemical warfare. Their toxicity is due to their direct inhibition of acetylcholinesterase (AChE), an enzyme that is vital to the nervous system via regulation of the neurotransmitter acetylcholine (ACh). AChE in…
  • College: College of Arts & Sciences
  • Inventors: Hadad, Christopher; Callam, Christopher; Corrigan, Thomas; Dicken, Rachel; Dogan Ekici, Ozlem; Fitzpatrick, Keegan; Franjesevic, Andrew; McElroy, Craig; McKenney, Ryan; Muthukrishnan, Siva; Sanan, Toby; Vyas, Shubham; Yoder, Ryan; Young, Amneh "Amneh"
  • Licensing Officer: Willson, Christopher

Quadruplex-based non-enzymatic DNA signal amplification
TS-042905 — A quadruplex-based non-enzymatic DNA signal amplification scheme for point of care diagnostic testing.
Currently, non-enzymatic signal amplification assays, an alternative to PCR, are complicated reactions employing multiple DNA constructs. The most successful non-enzymatic assays rely on stand-displacement reactions within DNA duplexes that result in background activity. Because of this background…
  • College: College of Arts & Sciences
  • Inventors: Kankia, Besik
  • Licensing Officer: Willson, Christopher

Machine-Learning Algorithm for Improved Speech Intelligibility in Noise
TS-042266 — A monaural machine-learning algorithm for classifying time-frequency units in an unknown signal, which results in marked speech-intelligibly improvements in noisy signals.
A primary complaint of hearing-impaired (HI) listeners is poor speech recognition in background noise. This issue can be quite debilitating and persists despite considerable efforts to improve hearing technology. Despite considerable effort, monaural (single-microphone) algorithms capable of incre…
  • College: College of Arts & Sciences
  • Inventors: Healy, Eric; Vasko, Jordan
  • Licensing Officer: Hong, Dongsung

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