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Method to improve efficiency and specificity of human tumor targeting and elimination by using a combination of split & splice protein toxins and oncolytic viruses

TS-040838 — Novel strategy to improve efficiency and specificity of tumor treatment via combinative use of a split & splice protein toxin and oncolytic virus.

In combating malignancies as complex as cancer, researchers and clinicians have created a diverse set of strategies to reduce tumor burden. Oncolytic viruses (OVs) have emerged as a promising means of treating this disease due to their potential to selectively target and effectively kill cancer ce…

College: College of Arts & Sciences
Inventors: Kudryashov, Dmitri; Kudryashova, Elena
Licensing Officer: Flammang, Ann Marie

Synthetic apratoxins and novel analogs for anticancer and therapeutic applications

TS-039269 — Synthetic natural apratoxins and non-natural apratoxin analogs with improved pharmacokinetic profiles for cancer treatments and drug development applications.

Apratoxins are potent cytotoxic biosynthetic products that are naturally produced by specific marine microorganisms. When isolated from organisms, the compounds display very potent anticancer activities. In addition, they have been implicated in immunosuppressive activity. However, in their natura…

College: College of Arts & Sciences
Inventors: Forsyth, Craig; Jackel, Matthew; Li, Xiao
Licensing Officer: Paschall, Christopher

Design and apparatus for quantification of the mapping of the sensory areas of the brain

TS-039164 — A new tool that can quantify the sensory maps of the human brain. The tool can be used to quantify plasticity and pathology in the sensory areas of the human brain that are associated with normal and abnormal development, aging, and diseases in sensory systems. The first application of the tool, on retinotopic maps of the visual cortex, has generated excellent results.

By analyzing the stimulus-referred fMRI responses in each voxel of an MR image, retinotopic mapping of human visual cortex can generate cortical maps of the visual space. These maps elucidate the spatial organization of the neuronal responses to visual images. Although numerous studies have b…

College: College of Arts & Sciences
Inventors: Wang, Yalin; Lu, Zhong-Lin; Ta, Duyan
Licensing Officer: Norris, Francis "Frank"

Paper-based Dried Blood Spheroids for Stabilization of Labile Organic Compounds Stored in Ambient Air

TS-038604 — Apparatus and methods to form three-dimensional dried blood spheroids on hydrophobic paper substrates.

Dried blood spots on paper substrates offer a facile sample collection, storage, and transportation approach for biofluids. However, variable diffusion, volcanic effects, analyte instability, and difficulty in recovering samples from paper plague this method, lowering confidence in analyte quantif…

College: College of Arts & Sciences
Inventors: Badu-Tawiah, Abraham; Damon, Deidre
Licensing Officer: Gooray, Arthur "Art"

Method for treatment of diseases of central nervous system (CNS) and improvement of cognitive function by nanoscaffolds

TS-038406 — A novel method to improve CNS metabolism and overall cognitive function as well as reduce peripheral neurodeneration, through the use of nanomatrices with or without identified redefined delivery biologicals and/or insulin.

The central nervous system (CNS) can be implicated in a broad category of diseases in which the brain does not function as expected. Conditions may result from a metabolic disorder; damage from an infection, a degenerative condition, stroke, a brain tumor or other problem; or arise from unknown or…

College: College of Arts & Sciences
Inventors: Ziouzenkova, Ouliana; Parquette, Jonathan
Licensing Officer: Flammang, Ann Marie

Scalable solution-phase routes to carbides

TS-038007 — A method for synthesizing a broad class of metal carbide materials.

Select early-transition metal carbides have significant catalytic and electrocatalytic applications, including fuel cell reactions and biomass conversion. The hydrogen-transfer reaction rates of these carbides is comparable to expensive, less abundant materials. Therefore, the preparation of monod…

College: College of Arts & Sciences
Inventors: Goldberger, Joshua; Baum, Zachary
Licensing Officer: Wohlgamuth, Christopher

Absolute Minimal Sampling of Homonuclear 2D NMR TOCSY Spectra for High-Throughput Applications of Complex Mixtures

TS-037865 — A technique to increase the processing speed of data collection without losing accuracy

Modern applications of 2D NMR spectroscopy for diagnostic screening, metabolomics, quality control, and other high-throughput applications are limited by the time-consuming sampling requirements. 2D Total Correlation Spectroscopy (TOCSY) provides unique spin connectivity information for the analys…

College: College of Arts & Sciences
Inventors: Bruschweiler, Rafael; Hansen, Alexandar "Alex"; Li, Dawei "Dawei"
Licensing Officer: Wohlgamuth, Christopher

Electrolyte to Enable Reversible Dendrite-Free Potassium Plating and Stripping for Potassium Secondary Batteries

TS-037854 — A novel electrolyte to prevent dendrite growth in potassium air batteries.

The Need Potassium-air batteries have recently emerged as alternative energy storage devices beyond lithium-ion batteries. However, potassium metal anodes suffer from poor reversibility during plating and stripping processes due to their high reactivity and unstable solid electrolyte interphase (SE…

College: College of Arts & Sciences
Inventors: Wu, Yiying; McCulloch, William; Xiao, Neng
Licensing Officer: Wohlgamuth, Christopher

A Novel Microbial Therapeutic to Diminish the Risk of Arteriosclerosis and Subsequent Heart Disease

TS-037792 — Novel bacteria, specially formatted, could be utilized as a microbial therapeutic for diminishing the risk of arteriosclerosis and subsequent heart disease.

Cardiovascular disease is the leading cause of mortality in the United States. Evidence is accumulating that certain human intestinal microbes contribute to atherosclerosis leading to cardiovascular disease, thereby increasing the risk of heart attack, stroke, and death. Gut microbes convert quate…

College: College of Arts & Sciences
Inventors: Krzycki, Joseph; Ferguson, Donald; Kountz, Duncan
Licensing Officer: Dahlman, Jason "Jay"

Immobilization of Biomolecules (Rubisco) by Self-Assembled Nanostructures

TS-037787 — Nanostructures that enhance the stability of biocatalysts that permit them to be utilized in scalable CO2 conversion processes

Carbon dioxide (CO2) and methane (CH4) are the two most abundant greenhouse gasses, trapping thermal radiation close to the earth's atmosphere and contributing to climate change. These two gasses contributed up to 92% of all the greenhouse gas emissions in 2015 (epa.gov). From an industrial pe…

College: College of Arts & Sciences
Inventors: Parquette, Jonathan; Satagopan, Sriram; Sun, Yuan; Tabita, Fred
Licensing Officer: Flammang, Ann Marie

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