The Need

In the rapidly advancing landscape of life sciences, researchers and biotech companies face an escalating demand for reliable and versatile cell lines. The need for a specialized cell line that combines adaptability, reproducibility, and ease of use is paramount in accelerating breakthroughs in various fields, including drug discovery, regenerative medicine, and cell-based therapies.

The Technology

Introducing our cutting-edge Cell Line, derived from the immortal parental line 24B-Ras-RMCE-L5 detailed in RT-038951. These clonal cells, modified with a puromycin resistance gene, offer a unique and valuable resource for researchers seeking a versatile platform for their experiments. With 44 passages completed as of February 2, 2022, these cells demonstrate remarkable stability and reproducibility. Notably, Clone 24B5 B8 exhibits the ability to differentiate upon exposure to the molting hormone ecdysone, expressing the muscle-specific protein Myosin Heavy Chain.

Commercial Applications

• Drug Discovery: Streamline pharmaceutical research by utilizing a stable and reproducible cell line for drug screening and toxicity studies.
• Regenerative Medicine: Explore the potential of cell-based therapies with a cell line capable of controlled differentiation, offering insights into tissue regeneration.
• Biomedical Research: Accelerate breakthroughs in understanding cellular processes, especially those related to muscle development and contraction.
• Toxicology Studies: Conduct comprehensive toxicity assessments with a versatile cell line that responds dynamically to external stimuli.
• Genetic Engineering: Facilitate genetic modification experiments with a well-defined and clonally related cell line.

Benefits/Advantages

• Versatility: Our Cell Line provides a versatile platform for a wide range of applications, enabling researchers to address diverse scientific questions.
• Stability: With 44 passages completed, the cell line demonstrates exceptional stability, ensuring consistent and reliable results over time.
• Clonal Relationship: Derived from a clonal selection process, researchers can trust the reproducibility of results, crucial for scientific rigor.
• Controlled Differentiation: The ability to differentiate upon exposure to ecdysone offers researchers precise control over cellular behavior, particularly in studies related to muscle development.
• Expression of Myosin Heavy Chain: The expression of this muscle-specific protein enhances the relevance of the Cell Line for studies focused on muscle-related disorders and therapies.