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Targeting β-catenin signaling in combination with EGFR TKI enhances progression free survival and overall survival of EGFR mutant NSCLC

TS-042666 — The discovery of a novel treatment for EGFR TKI drug resistance in NSCLC.

Non-small cell lung cancer (NSCLC), which accounts for 85% of all lung cancers, is one of the leading causes of cancer-related death. Substantial progress has been made in the management of NSCLC as several driver mutations have been identified in cell communication pathways involved in lung tumor…

College: College of Medicine (COM)
Inventors: Arasada, Rajeswara Rao; Carbone, David
Licensing Officer: Paschall, Christopher

Closed Loop Particle Forecasting Platform for Decision Support and System Prognostics.

TS-042531 — A computational platform for forecasting the state of evolving systems and processes.

Particle methods are a class of computational algorithms used to estimate potential outcomes of a system or process. Although popular for their simplicity and scalability, the use of fixed sized "particle ensembles" renders the simulations unable to provide performance guarantees in quan…

College: College of Engineering (COE)
Inventors: Kumar, Mrinal "Mrinal"; Yang, Chao "Chao"
Licensing Officer: Wohlgamuth, Christopher

High-strength and Corrosion Resistant Alloy for Patient-Specific Bioresorbable Bone Fixation Hardware

TS-042526 — A novel quaternary Mg-Zn-Ca-based alloy and a heat treatment process for producing bioresorbable bone fixation implants with improved mechanical and corrosion properties

Mg-Zn-Ca-based alloys are the most promising alloy system for bone implant applications mainly due to their superior biocompatibility. For patient-specific (3D-printed) fixation hardware made of such alloys, various heat treatment processes have been employed to enhance the mechanical or corrosion…

College: College of Medicine (COM)
Inventors: Dean, David; Elahinia, Mohammad; Ibrahim, Hamdy
Licensing Officer: Norris, Francis "Frank"

miRNA Biomarkers for Diagnosis and Prediction of Radiation Induced Injury

TS-041968 — A minimally invasive procedure to determine radiation toxicity in victims of nucler events or radiation therapy patients.

The lack of a reliable radiation biodosimeter has been a major barrier to medical decision-making regarding the triage and treatment of persons - civilians, soldiers and first-time responders - who might be at risk for developing acute radiation syndromes (ARS) following nuclear events (e.g. nucle…

College: College of Medicine (COM)
Inventors: Jacob, Naduparambil "Naduparambil"
Licensing Officer: Norris, Francis "Frank"

Amine-Containing Facilitated Transport Membranes For Carbon Dioxide/Nitrogen Separation

TS-041856 — Novel membrane technology utilizing active transport for carbon dioxide/nitrogen separation. The membrane exhibits high permeance and selectivity

Improved separation of by-product carbon dioxide from nitrogen in power plants and industrial exhaust systems would considerably decrease greenhouse gas emissions. The current method of separation that is most often used in industry is amine absorption, however this method is costly, has a large c…

College: College of Engineering (COE)
Inventors: Ho, W.S. Winston; Han, Yang
Licensing Officer: Gooray, Arthur "Art"

DAtAnchor: A Multi-Layer Data Loss Mitigation System

TS-041846 — An alternative to traditional data security measures. The technology effectively "anchors" the information to one location, allowing for better security and making it harder to compromise access.

Data breaches are a looming risk for organizations that maintain significant repositories of sensitive data. The fundamental reason behind their inability to prevent them is the philosophy behind the current paradigm in data security: prevent all breaches at all times. Towards that end, existing a…

College: College of Engineering (COE)
Inventors: Koksal, C. Emre
Licensing Officer: Smith, Richard

Junctional Tourniquet for Groin and Axillary Regions

TS-041808 — A tourniquet with a ratcheting lock to keep pressure on wounds in the groin and axillary regions. Hemostasis can be achieved while the patient is still in the field.

Patients with blood loss in the field need to be treated immediately to prevent ongoing blood loss, shock, and death; bleeding from extremity and junctional wounds is the leading cause of potentially preventable death from penetrating injuries. Direct manual pressure is effective for the initial c…

College: OSU Wexner Medical Center
Inventors: McElroy, James; Graham, Nadi; Nocera, Tanya
Licensing Officer: Flammang, Ann Marie

Nonadhesive Medical Tube Attachment Device

TS-041656 — A device that holds nasogastric tubes, oxygen nasal cannulas, and facial dressings without adhesive.

Nasogastric tubes are used to give patients food and medications. Current commercially available tube holders are adhesive devices that attach to the nose. The devices put pressure on the nose and have to be completely removed to check the skin underneath or to adjust the tubes. Oxygen nasal cannu…

College: OSU Wexner Medical Center
Inventors: Huffman, Jennifer; West, Tabitha
Licensing Officer: Flammang, Ann Marie

FARM: Fertilizer Application Resource Monitor

TS-041592 — FARM is a real-time mobile application that uses precipitation forecasts to guide farmers in their use of fertilizer and pesticides.

Weather forecasting is a useful tool for farmers who need to decide how best to treat their crops. Applying fertilizer or pesticide to crops, just to have the rain wash it away, results in a waste of resources. Additionally, many areas such as Ohio have regulations for fertilizer and pesticide run…

College: Office of Academic Affairs
Inventors: Wilson, Aaron
Licensing Officer: Dahlman, Jason "Jay"

Papverine Derivatives as Metabolic Radiosensitizers

TS-041504 — Papverine derivatives that can be used as metabolic radiosensitizers. The compounds make cancer cells more sensitive to radiation therapy without the concomitant toxicity issues that can occur as a side-effect of papverine.

Radiation therapy is a common treatment for cancerous tumors. Different types of cancer cells have varying sensitivity to radiation therapy, and some are almost unaffected by treatment. For example, breast cancer, glioblastoma, bladder cancer, and soft-tissue carcinoma do not react well to radiati…

College: College of Medicine (COM)
Inventors: Denko, Nicholas; Benej, Martin; Mitton-Fry, Mark; Papandreou, Ioanna; Vibhute, Sandip
Licensing Officer: Paschall, Christopher

RadApp: A mobile application solution for centralized distribution of information to improve workflow, communication, networking, education, and patient safety in the healthcare setting.

TS-041197 — Medical institutions depend on accessing many sources of changing information in various different forms to be successful. Moreover, distributing this information in a concise user-friendly way for each role in the department can be difficult. In particular, this is important for busy, tertiary-le…

College: College of Medicine (COM)
Inventors: Makary, Mina; Egbert, Nitin
Licensing Officer: Flammang, Ann Marie

Method to improve efficiency and specificity of human tumor targeting and elimination by using a combination of split & splice protein toxins and oncolytic viruses

TS-040838 — Novel strategy to improve efficiency and specificity of tumor treatment via combinative use of a split & splice protein toxin and oncolytic virus.

In combating malignancies as complex as cancer, researchers and clinicians have created a diverse set of strategies to reduce tumor burden. Oncolytic viruses (OVs) have emerged as a promising means of treating this disease due to their potential to selectively target and effectively kill cancer ce…

College: College of Arts & Sciences
Inventors: Kudryashov, Dmitri; Kudryashova, Elena
Licensing Officer: Flammang, Ann Marie

Ultra-Fast Charging Li-ion Battery Anodes

TS-040614 — A novel battery anode designed to overcome the limitations posed on fast charge batteries by graphite anodes. The new anode increases battery life, is more stable during manufacturing, and has improved heat dissipation qualities.

As technology continues to progress, embedding itself in our daily life from our cars to our wrists, an ever-present concern is the need for batteries with the ability to re-charge quickly. Most of these emerging technologies use Li-ion batteries with graphite anodes. Unfortunately, under fast cha…

College: College of Arts & Sciences
Inventors: Co, Anne; Bascaran, Julen
Licensing Officer: Gooray, Arthur "Art"

Small molecule modulators of Avian Pathogenic E. coli (APEC) virulence as a means to control avian collibacillosis

TS-040540 — Small molecules have been developed that have shown effective defense against Avian pathogenic Escherichia coli (APEC). These molecules can be used by itself, or with current antibiotics, which helps decrease the overall risk of bacterial antibiotic resistance.

Avian pathogenic Escherichia coli (APEC) is one of the most common poultry diseases that is characterized by a series of extra intestinal infections that effect the visceral organs of the bird. The disease affects chickens, turkeys, and other avian species, and highly reduces egg production and we…

College: College of Food, Agricultural, and Environmental Sciences (CFAES)
Inventors: Rajashekara, Gireesh; Deblais, Loic; Kathayat, Dipak; Mohamed, Yosra
Licensing Officer: Dahlman, Jason "Jay"

Hollow Valve for an Engine

TS-040523 — A coolant-free valve with a hollow vacuum cavity which reduces heat conduction and improves the efficiency of engines

Valves are essential components of engines that regulate intake of fuel and air and removal of combustion products. Solid valves conduct a significant amount of heat, which reduces the efficiency of the combustion process. Previous hollow valve designs fill the inner chamber with low-melting metal…

College: College of Engineering (COE)
Inventors: Zhao, Ji-Cheng
Licensing Officer: Gooray, Arthur "Art"

Learning Optimal Empirical Reward iNtelligence (LOERN) with Cyber Maintenance Applications

TS-040341 — A software solution designed to optimize cyber security decision making and reduce maintenance costs.

As the world becomes more and more connected, our systems become more and more vulnerable. If cyber security can become more automated, risk-based decisions can be made more quickly and rationally. Organizations can then leverage this decision-making to improve their security without increasing co…

College: College of Engineering (COE)
Inventors: Allen, Theodore; Hou, Chengjun
Licensing Officer: Wohlgamuth, Christopher

Multifunctional RNA Nanoparticles and Methods for Treating Cancer

TS-040289 — Three-way junction nanoparticles for delivery of tamoxifen and other therapeutics directly to tumor cells.

Most breast cancers express estrogen receptor alpha (ER α) and antagonists of ER α drugs, such as tamoxifen, have been widely used for their treatment. Unfortunately, up to half of all ER α -positive tumors have intrinsic or acquired endocrine therapy resistance. Recent studies b…

College: College of Pharmacy
Inventors: Zhang, Xiaoting; Guo, Peixuan
Licensing Officer: Flammang, Ann Marie

Novel compositions of nanoparticles for nucleic acid therapeutic delivery

TS-040254 — Novel lipid-based nanoparticles that utilize a surfactant to improve self-assembly and stability. Finalized particles can be used for delivery of nucleic acids such as oligonucleotides and plasmid DNA.

Lipid-based nanoparticles (LNPs) have been extensively utilized in nucleic acid delivery. However, there are a number of challenges associated with LNP formulation. It is difficult to make sub-100-nm LNPs with a high nucleic acid concentration by traditional self-assembly methods. LNP synthesis ty…

College: College of Pharmacy
Inventors: Lee, Robert
Licensing Officer: Flammang, Ann Marie

The OSU Soil Organic Matter Calculator

TS-040136 — The Ohio State University’s Soil Organic Matter Calculator is a program that can be used to calculate future organic soil quality, greenhouse gas emissions, nitrogen fertility over short- and long-term scenarios in rder to help farmers decide more sustainable methods of agriculture.

Farmers, scientists, educators, industries and other non-profit organizations are increasing in need of a simple way to make accurate models and simulations of the environmental impact of land management choices and practices. Various different group and organizations from a wide variety of indust…

College: College of Food, Agricultural, and Environmental Sciences (CFAES)
Inventors: Islam, Khandakar; Grigar, Jerry; Reeder, Randall; Shedekar, Vinayak
Licensing Officer: Dahlman, Jason "Jay"

Identifying the level of lupus patients’ comprehension of their medication regimens and disease outcomes

TS-040132 — A questionnaire used to understand a patient’s comprehension of their personalized medication plan and the disease fluctuation of systemic lupus erythematous (SLE).

Systemic lupus erythematous (SLE) is an autoimmune disease in which the body’s immune system attacks healthy tissue in its own body. The disease has a prevalance of twenty to 150 cases per 100,000 individuals, and is more common in females than in men. This chronic disease has no cure, and s…

College: College of Medicine (COM)
Inventors: Meara, Alexa; Ardoin, Stacy; Peters, Ellen
Licensing Officer: Dahlman, Jason "Jay"

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