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Next-generation method for flow estimation and geospatial mapping of agricultural particulates
TS-046029 — Next-generation agricultural sensor technology enables precise, data-based decision-making to be implemented at the farm level. Field operations data such as granular fertilizer application rates are useful to the producer, because optimization of nutrient supplementation increases use efficiency …
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Colley III, Richard; Fulton, John
  • Licensing Officer: Dahlman, Jason "Jay"

Compact Cas9-based transcriptional regulators for in vivo gene regulation
TS-045681 — Cas9-derived constructs can be used to modulate gene expression, but physical limitations restrict the application of this technique. Researchers at The Ohio State University have overcome this obstacle by engineering new Cas9-derived transcription factors.
CRISPR/Cas9 systems have revolutionized the field of programmable DNA technology. Recently, a version of the Cas9 protein with a deactivated nuclease domain called “dCas9” was developed. Without this domain, dCas9’s range of activity is limited to recognizing and binding sequence…
  • College: College of Medicine (COM)
  • Inventors: Han, Renzhi; Gao, Yandi; Xu, Li
  • Licensing Officer: Dahlman, Jason "Jay"

mRNA sequence engineering and uses thereof
TS-045448 — Maximized mRNA lifespan and translation for mRNA-based therapy applications.
Many diseases emerge from irregularities that occur during protein synthesis. While limited therapies exist to deliver mature proteins to compensate for these errors, protein therapy by direct protein delivery has limited efficiency. This is due to difficulty in controlling the volume of delivered…
  • College: College of Pharmacy
  • Inventors: Dong, Yizhou; Zeng, Chunxi
  • Licensing Officer: Dahlman, Jason "Jay"

Improving immunotherapy with mRNA delivery
TS-045426 — The central mission of cancer immunotherapy treatments is to aid the immune system in detecting and degrading cancer cells. For twenty years, the use of monoclonal antibodies (mAbs) as anti-tumor drugs has been successful in managing cancer disease and increasing patient lifespan. These treatments…
  • College: College of Pharmacy
  • Inventors: Dong, Yizhou; Li, Wenqing; Zhang, Chengxiang
  • Licensing Officer: Dahlman, Jason "Jay"

Nanomaterials for combinational therapy applications
TS-045268 — (mRNA)-based therapeutics
Combinational therapies for cancer that integrate chemotherapy with another method of treatment can minimize side-effects and maximize the efficacy of treatment. Recently, messenger RNA (mRNA)-based therapeutics have been recognized as a new class of cancer treatments with substantial development …
  • College: College of Pharmacy
  • Inventors: Dong, Yizhou; Zhang, Chengxiang; Zhang, Xinfu
  • Licensing Officer: Dahlman, Jason "Jay"

Isolated Milk Phospholipids and MFGM
TS-045170 — Process for isolating and producing a high milk phospholipid ingredient from a by-product of the dairy industry, also commonly known as Milk Fat Globule Membrane (MFGM).
Milk phospholipds are in demand in the food industry because they promote good gut health and cognitive development in adults and infants. Currently, phospholipids can be extracted from a high fat fraction of milk sweet whey. Unlike the sweet whey from natural cheese manufacturing, the acid whey f…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Jimenez-Flores, Rafael; Ortega-Anaya, Joana
  • Licensing Officer: Flammang, Ann Marie

Improved Dressing Design for Insertion Sheaths with Side Ports
TS-044969 — Dressing designed and tailored exclusively for insertion sheaths with side ports, used frequently for pulmonary artery catheters (PACs or Swan-Ganz catheters) among other intravascular devices in the hospital.
The Need Central-line associated blood stream infections (CLABSIs) are a life-threatening and extremely costly problem in hospitals around the world. When patients in the hospital have indwelling catheters such as pulmonary artery catheters, they are at an increased risk of developing such infectio…
  • College: OSU Wexner Medical Center
  • Inventors: Warren, Samantha; Thomas, Jordan
  • Licensing Officer: Flammang, Ann Marie

Method to improve natural rubber (hevea/guayule)-toughened poly-(3-hydroxybutyrate-co-3-hydroxyvalerate)(PHBV) for food packaging applications
TS-044688 — Nearly all plastics that are used to produce packaging materials are petroleum-based and non-biodegradable. This makes their use undesirable to consumers in an increasingly sustainability-focused market. Therefore, the development of biologically-derived, biodegradable plastic for packaging materi…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Vodovotz, Yael; Cornish, Katrina; Koelling, Kurt; Venoor, Varun "varun"; Zhao, Xiaoying "Xiaoying"
  • Licensing Officer: Dahlman, Jason "Jay"

Electrophiles for Re-activation of Aged Acetylcholine Esterase
TS-044619 — Organophosphorus (OP) poisons including sarin, VX, and novichoks are lethal agents of chemical warfare. Their toxicity is due to their direct inhibition of acetylcholinesterase (AChE), an enzyme that is vital to the nervous system via regulation of the neurotransmitter acetylcholine (ACh). AChE in…
  • College: College of Arts & Sciences
  • Inventors: Hadad, Christopher; Callam, Christopher; Corrigan, Thomas; Dicken, Rachel; Dogan Ekici, Ozlem; Fitzpatrick, Keegan; Franjesevic, Andrew; McElroy, Craig; McKenney, Ryan; Muthukrishnan, Siva; Sanan, Toby; Vyas, Shubham; Yoder, Ryan; Young, Amneh "Amneh"
  • Licensing Officer: Dahlman, Jason "Jay"

Isolation of Porcine Epidemic Diarrhea Virus (PEDV) strain Iowa106
TS-044567 — Porcine epidemic diarrhea virus (PEDV) appeared in the US in 2013 and has spread rapidly throughout North America. The virus causes gastroenteric disease in adults and is fatal to nursing piglets, whose only protection from the disease is via passive immunity from their mother. Currently, most US …
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Wang, Qiuhong; Oka, Tomoichiro; Saif, Linda
  • Licensing Officer: Dahlman, Jason "Jay"

Biomimetic vitreous substitute with ocular drug delivery
TS-044490 — Methods and compositions for an antioxidant releasing hydrogel vitreous substitute
The vitreous humor is a fragile, transparent tissue between the lens and the retina of the eye that maintains the shape of the eye, acts as a shock absorber, and enables nutrient diffusion to ocular tissues. The vitreous also plays a key role in oxygen homeostasis. Over time, the vitreous degrades…
  • College: College of Engineering (COE)
  • Inventors: Swindle-Reilly, Katelyn; Reilly, Matthew; Tram, Nguyen "Archie"
  • Licensing Officer: Flammang, Ann Marie

Antimicrobials to Control Campylobacter
TS-044474 — Campylobacter is a leading cause of foodborne disease in humans, affecting more than one million Americans each year. Campylobacteriosis is projected to remain one of the most-frequent causes of disease and death worldwide. Human infection primarily occurs by ingesting contaminated chicken, and tr…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Rajashekara, Gireesh; Acuna, Ulyana Munoz; Antwi, Janet; Carcache de Blanco, Esperanza; Fuchs, James; Kumar, Anand; Nislow, Corey; Pascall, Melvin
  • Licensing Officer: Dahlman, Jason "Jay"

Nanoparticle Composition for Nucleic Acid Delivery
TS-044109 — Lipid nanoparticles (LNs) usable for the delivery of therapeutic compositions, including, but not limited to nucleic acids (NAs).
Nucleic Acid (NA) based therapies are used to inhibit gene expression. Lipid nanoparticles (LNs) are capable of carrying these therapies into cells. However, this delivery requires overcoming several physiological barriers. For instance, one barrier is the acidic endosome conditions within the cel…
  • College: College of Pharmacy
  • Inventors: Lee, Robert
  • Licensing Officer: Flammang, Ann Marie

Live vaccine candidate for Chagas disease
TS-044084 — Trypanosoma cruzi is a protozoan parasite that causes Chagas disease, a PRV-eligible disease that is the leading cause of heart failure in Latin America. Due to migration of infected hosts from endemic regions, Chagas disease is also a growing public health concern in the USA and other migrant des…
  • College: College of Medicine (COM)
  • Inventors: McGwire, Bradford
  • Licensing Officer: Dahlman, Jason "Jay"

System for Immobilizing the Skull during Transcranial Focused Ultrasound Ablation
TS-043964 — A non-invasive method for immobilizing the skull of a patient undergoing surgery. The device consists of pads for contacting screws from a standard stereotactic frame and a headband that result in immobilization without damage to the skin or skull.
Both stereotactic neurosurgery and transcranial focused ultrasound surgery systems have historically required a stereotactic frame to precisely position and completely immobilize a patient's head to ensure the correct location for the operation. This frame consists of multiple pins that must b…
  • College: College of Medicine (COM)
  • Inventors: Sammartino, Francesco; Beam, Dylan; Krishna, Vibhor
  • Licensing Officer: Flammang, Ann Marie

Translational Activators of the Glutamate Transporter EAAT2 to Treat Neurological and Psychiatric Diseases
TS-043938 — Small molecule technology with novel translational activation mechanism.
Glutamate is a major neurotransmitter in the mammalian central nervous system (CNS) and essential for normal brain function including cognition, memory, and learning. However, the extracellular concentration of glutamate must remain below excitotoxic levels (~ 1 μM) to avoid overstimulation of …
  • College: College of Medicine (COM)
  • Inventors: Lin, Chien-Liang; Hodgetts, Kevin
  • Licensing Officer: Dahlman, Jason "Jay"

DNA-cage erasable labels for fluorescence-based imaging
TS-043819 — Compositions and methods for analyzing multiple biomarkers without damaging tissue.
Histopathology is a cornerstone of tissue analysis used to diagnose many clinical conditions. Many of these diagnoses are based on identifying the presence of specific biomarkers, which can be indicated by colored labels. Currently, only 1-2 markers can be analyzed per slide, reducing accuracy and…
  • College: College of Engineering (COE)
  • Inventors: Winter, Jessica; Jergens, Elizabeth; Lee, Kil Ho "Kilho"
  • Licensing Officer: Dahlman, Jason "Jay"

Novel Large Scale All-Male Bluegill Production Technology & All-Female Yellow Perch Production Technology
TS-043636 — A novel technique for the large scale production of male bluegill (GMB) stock through selective breeding methods and for large scale production of all female yellow perch fish stock by means of dietary supplements. This technique improves growth rate, size, and survivability. For more information, please see related pdf upload.
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Wang, Hanping
  • Licensing Officer: Dahlman, Jason "Jay"

Cold responsive nanoparticles for overcoming cancer drug resistance
TS-043509 — A cold-responsive nanoparticle that quickly disassembles upon ice cooling leading to intracellular burst release of a chemotherapeutic drug in seconds
Stimuli-responsive nanoparticles (NPs) hold great promise for controlling drug release inside cancer cells. An obstacle to the effectiveness of this approach to chemotherapeutic drug delivery is the rapid expulsion of the delivered drug catalyzed by efflux pumps in the cell's plasma membrane. …
  • College: College of Engineering (COE)
  • Inventors: He, Xiaoming "Shawn"; Wang, Hai
  • Licensing Officer: Norris, Francis "Frank"

Folding Transducer Array for Compact and Deployable Wave-Energy Guiding System
TS-043186 — A novel acoustic/ultrasonic wave-energy guiding system that utilizes structural topology to enhance directional and spectral sensitivities instead of phase delay, offering exceptional versatility and adaptable performance.
Although acoustic beamforming systems that are based on phase delays can be used to enhance directional and spectral sensitivities, each source or receiver must be individually controlled by appropriate phase delays to guide the acoustic energy radiation/reception sensitivities. This results in a …
  • College: College of Engineering (COE)
  • Inventors: Harne, Ryan
  • Licensing Officer: Norris, Francis "Frank"

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