TS-060782 — Problem Statement: Diagnosis of arterial occlusion and an associated stroke can be lengthy, delaying patient access to treatment. As large vessel occlusions account for 24 to 46% of acute ischemic strokes and may require treatment in a comprehensive stroke center, early diagnosis is key. Solution:…

TS-060542 — The Problem Swine influenza is an acute respiratory disease of pigs caused by swine influenza A virus (SwIAV). Pigs are naturally vulnerable to SwIAV-associated with secondary bacterial infections and is an economic threat to the global pig industry. Commonly circulating SwIAV strains in swine popu…

TS-060522 — The Problem Solanaceae vegetables including peppers and tomatoes are economically important crops worldwide. In 2020, tomatoes (186 million metric tons) and peppers (36 million metric tons) were among the most produced vegetable crops globally. The USA is one of the top producers of tomatoes and pe…

TS-060092 — AI methods and systems for predicting reactants and their synthesis paths to support drug design and chemical synthesis.

TS-059635 — & T2014-282 A method to discover narrow-spectrum antibiotics of salmonellosis, as well as small molecule inhibitors of Salmonella FraB and a Salmonella probiotic strain to enhance the efficacy of FraB inhibitors.

TS-059578 — A novel biomarker for the early identification of cardiac damage, including chemotherapy-induced cardiotoxicity.

TS-059537 — An untargeted NMR-based metabolomics approach to identify metabolic compounds as signatures of bacterial joint infections and methods for the treatment and prevention thereof.

TS-059106 — Rubber is a crucial material used worldwide, but it is becoming scarce due to high demand and limited areas to grow rubber trees. New methods and processes are needed to overcome the shortage of this essential material.

TS-059105 — Food shortages around the world affect hundreds of millions of people daily due to environmental and political issues. New technologies are needed to improve the quantity and quality of food in resource-limited areas.

TS-059056 — A platform for improving simulations across many industries. Developing real-life simulations of disasters is vital for safety and reducing their financial impact; however, current simulation tools are bulky, expensive to implement, and require advanced technical skills to operate.

TS-058669 — A knock-in mouse model carrying a modified dopamine transporter that is resistant to cocaine inhibition and thus showing no rewarding cocaine effects.

TS-058668 — A knock-in mouse model with a modified norepinephrine transporter carrying triple mutations that makes the transporter protein resistant to cocaine and antidepressants.

TS-058447 — The emergence of quantum computing has uncovered a new set of error code detection and correction challenges. New technologies are needed to correct quantum and data transmission errors to accelerate the field’s growth and implementation.

TS-058408 — Freshwater resources around the world are under stress due to naturally occurring events and human impacts, causing an increase in cyanobacteria blooms. These cyanobacteria release harmful toxins, known as cyanotoxins. The proposed USV degrades the toxins on-site with UV light, reducing the accumulation of toxins, preventing groundwater contamination, and improving water quality.

TS-058084 — A rabbit model has been created for Duchenne Muscular Dystrophy (DMD) that more closely resembles the effects experienced in humans while being more cost effective compared to larger animal models.

TS-057780 — A novel, low-cost, and massively-parallel force spectroscopy strategy that leverages microfluidic technology to dynamically test strength of molecular binding interactions to enable quick, full characterization of a molecular interaction of interest.

TS-057778 — A novel monoclonal antibody (PIIO-1) to be used in combination with immune-checkpoint blockers. PIIO-1 augments CD8+ T cells-induced anti-tumor immunity and overcomes ICB resistance by disrupting transforming growth factor-β (TGF-β), the center of a pathway significantly implicated in solid tumors and hematological malignancies. PIIO-1 inhibits TGFβ locally via a docking receptor, avoiding adverse and unforeseen side effects.

TS-057777 — A novel orally-active drug molecule that can inhibit pathological CD4+ T-cells at clinically translatable doses and, blunts progressive cardiac dysfunction and left-ventricular (LV) remodeling during Heart Failure (HF).

TS-057776 — A novel protein-drug conjugate of human serum albumin chemically conjugated to SN-38, solubilizing the potent chemotherapeutic. This therapy has the potential to treat many tumors with poor prognosis, including pancreatic, lung, breast, colorectal, ovarian, sarcoma, head and neck cancer, urothelial malignancies, and others.

TS-057739 — CRISPR/Cas 9 mediated targeting of MIR155HG in primary human T cells creates genomic deletions that disrupt transcription of mature microRNA-155 (miR-155, a miR associated with inflammation). Applying this treatment to donor T cells prior to allogenic hematopoietic stem cell transplantation (allo-HSCT) when treating hematological malignancies and other primary bone marrow disorders can prevent the development of aGVHD in patients.