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miRNA Biomarkers for Diagnosis and Prediction of Radiation Induced Injury

TS-041968 — A minimally invasive procedure to determine radiation toxicity in therapy patients or victims of nuclear accidents.

The lack of a reliable radiation biodosimeter has been a major barrier to medical decision-making regarding the triage and treatment of persons who might be at risk for developing acute radiation syndromes (ARS) following nuclear events (e.g. reactor accidents, "dirty bomb" assaults, etc…

College: College of Medicine (COM)
Inventors: Jacob, Naduparambil "Naduparambil"
Licensing Officer: Norris, Francis "Frank"

Amine-Containing Facilitated Transport Membranes For Carbon Dioxide/Nitrogen Separation

TS-041856 — Novel membrane technology utilizing active transport for carbon dioxide/nitrogen separation. The membrane exhibits high permeance and selectivity

Improved separation of by-product carbon dioxide from nitrogen in power plants and industrial exhaust systems would considerably decrease greenhouse gas emissions. The current method of separation that is most often used in industry is amine absorption, however this method is costly, has a large c…

College: College of Engineering (COE)
Inventors: Ho, W.S. Winston; Han, Yang
Licensing Officer: Gooray, Arthur "Art"

Junctional Tourniquet for Groin and Axillary Regions

TS-041808 — A tourniquet with a ratcheting lock to keep pressure on wounds in the groin and axillary regions. Hemostasis can be acheived while the patient is still in the field.

Patients with blood loss in the field need to be treated immediately to prevent ongoing blood loss, shock, and death; bleeding from extremity and junctional wounds is the leading cause of potentially preventable death from penetrating injuries. Direct manual pressure is effective for the initial c…

College: OSU Wexner Medical Center
Inventors: McElroy, James; Graham, Nadi; Nocera, Tanya
Licensing Officer: Flammang, Ann Marie

Nonadhesive Medical Tube Attachment Device

TS-041656 — A device that holds nasogastric tubes, oxygen nasal cannulas, and facial dressings without adhesive.

Nasogastric tubes are used to give patients food and medications. Current commercially available tube holders are adhesive devices that attach to the nose. The devices put pressure on the nose and have to be completely removed to check the skin underneath or to adjust the tubes. Oxygen nasal cannu…

College: OSU Wexner Medical Center
Inventors: Huffman, Jennifer; west, tabitha
Licensing Officer: Flammang, Ann Marie

FARM: Fertilizer Application Resource Monitor

TS-041592 — FARM is a real-time mobile application that uses precipitation forecasts to guide farmers in their use of fertilizer and pesticides.

Weather forecasting is a useful tool for farmers who need to decide how best to treat their crops. Applying fertilizer or pesticide to crops, just to have the rain wash it away, results in a waste of resources. Additionally, many areas such as Ohio have regulations for fertilizer and pesticide run…

College: Office of Academic Affairs
Inventors: Wilson, Aaron
Licensing Officer: Dahlman, Jason "Jay"

Papverine Derivatives as Metabolic Radiosensitizers

TS-041504 — Papverine derivatives that can be used as metabolic radiosensitizers. The compounds make cancer cells more sensitive to radiation therapy without the concomitant toxicity issues that can occur as a side-effect of papverine.

Radiation therapy is a common treatment for cancerous tumors. Different types of cancer cells have varying sensitivity to radiation therapy, and some are almost unaffected by treatment. For example, breast cancer, glioblastoma, bladder cancer, and soft-tissue carcinoma do not react well to radiati…

College: College of Medicine (COM)
Inventors: Denko, Nicholas; Benej, Martin; Mitton-Fry, Mark; Papandreou, Ioanna; Vibhute, Sandip
Licensing Officer: Paschall, Christopher

RadApp: A mobile application solution for centralized distribution of information to improve workflow, communication, networking, education, and patient safety in the healthcare setting.

TS-041197 — Medical institutions depend on accessing many sources of changing information in various different forms to be successful. Moreover, distributing this information in a concise user-friendly way for each role in the department can be difficult. In particular, this is important for busy, tertiary-le…

College: College of Medicine (COM)
Inventors: Makary, Mina; Egbert, Nitin
Licensing Officer: Flammang, Ann Marie

Simple tool for uniform excision and transfer of biological samples

TS-041193 — A novel tool that offers improved efficiency, convenience, and precision for excision of DNA and protein bands or biological tissues.

The use of gel electrophoresis and other similar techniques is an invaluable part of biological research and has been for several decades. A crucial point in this process is the cutting of specific bands of interest for further sequencing or experimentation. The precision and quality of these cuts…

College: College of Medicine (COM)
Inventors: Gadepalli, Venkat Sundar
Licensing Officer: Norris, Francis "Frank"

Method to improve efficiency and specificity of human tumor targeting and elimination by using a combination of split & splice protein toxins and oncolytic viruses

TS-040838 — Novel strategy to improve efficiency and specificity of tumor treatment via combinative use of a split & splice protein toxin and oncolytic virus.

In combating malignancies as complex as cancer, researchers and clinicians have created a diverse set of strategies to reduce tumor burden. Oncolytic viruses (OVs) have emerged as a promising means of treating this disease due to their potential to selectively target and effectively kill cancer ce…

College: College of Arts & Sciences
Inventors: Kudryashov, Dmitri; Kudryashova, Elena
Licensing Officer: Flammang, Ann Marie

Small molecule modulators of Avian Pathogenic E. coli (APEC) virulence as a means to control avian collibacillosis

TS-040540 — Small molecules have been developed that have shown effective defense against Avian pathogenic Escherichia coli (APEC). These molecules can be used by itself, or with current antibiotics, which helps decrease the overall risk of bacterial antibiotic resistance.

Avian pathogenic Escherichia coli (APEC) is one of the most common poultry diseases that is characterized by a series of extra intestinal infections that effect the visceral organs of the bird. The disease affects chickens, turkeys, and other avian species, and highly reduces egg production and we…

College: College of Food, Agricultural, and Environmental Sciences (CFAES)
Inventors: Rajashekara, Gireesh; Deblais, Loic; Kathayat, Dipak; Mohamed, Yosra
Licensing Officer: Dahlman, Jason "Jay"

Multifunctional RNA Nanoparticles and Methods for Treating Cancer

TS-040289 — Three-way junction nanoparticles for delivery of tamoxifen and other therapeutics directly to tumor cells.

Most breast cancers express estrogen receptor alpha (ER α) and antagonists of ER α drugs, such as tamoxifen, have been widely used for their treatment. Unfortunately, up to half of all ER α -positive tumors have intrinsic or acquired endocrine therapy resistance. Recent studies b…

College: College of Pharmacy
Inventors: Zhang, Xiaoting; Guo, Peixuan
Licensing Officer: Flammang, Ann Marie

Novel compositions of nanoparticles for nucleic acid therapeutic delivery

TS-040254 — Novel lipid-based nanoparticles that utilize a surfactant to improve self-assembly and stability. Finalized particles can be used for delivery of nucleic acids such as oligonucleotides and plasmid DNA.

Lipid-based nanoparticles (LNPs) have been extensively utilized in nucleic acid delivery. However, there are a number of challenges associated with LNP formulation. It is difficult to make sub-100-nm LNPs with a high nucleic acid concentration by traditional self-assembly methods. LNP synthesis ty…

College: College of Pharmacy
Inventors: Lee, Robert
Licensing Officer: Flammang, Ann Marie

The OSU Soil Organic Matter Calculator

TS-040136 — The Ohio State University’s Soil Organic Matter Calculator is a program that can be used to calculate future organic soil quality, greenhouse gas emissions, nitrogen fertility over short- and long-term scenarios in rder to help farmers decide more sustainable methods of agriculture.

Farmers, scientists, educators, industries and other non-profit organizations are increasing in need of a simple way to make accurate models and simulations of the environmental impact of land management choices and practices. Various different group and organizations from a wide variety of indust…

College: College of Food, Agricultural, and Environmental Sciences (CFAES)
Inventors: Islam, Khandakar; Grigar, Jerry; Reeder, Randall; Shedekar, Vinayak
Licensing Officer: Dahlman, Jason "Jay"

Identifying the level of lupus patients’ comprehension of their medication regimens and disease outcomes

TS-040132 — A questionnaire used to understand a patient’s comprehension of their personalized medication plan and the disease fluctuation of systemic lupus erythematous (SLE).

Systemic lupus erythematous (SLE) is an autoimmune disease in which the body’s immune system attacks healthy tissue in its own body. The disease has a prevalance of twenty to 150 cases per 100,000 individuals, and is more common in females than in men. This chronic disease has no cure, and s…

College: College of Medicine (COM)
Inventors: Meara, Alexa; Ardoin, Stacy; Peters, Ellen
Licensing Officer: Dahlman, Jason "Jay"

The FoodImage Smartphone App

TS-040080 — FoodImage quantifies food waste in near real-time using images of food products and food waste captured by end users or consumers.

Americans throw away approximately 80 billion pounds of food per year. However, in a study conducted by The Ohio State University, 53% of respondents indicated that food waste is a problem. A potential method to reduce food waste and its negative affects would be to increase awareness of the probl…

College: College of Food, Agricultural, and Environmental Sciences (CFAES)
Inventors: Roe, Brian; Apolzan, John; Martin, Corby
Licensing Officer: Dahlman, Jason "Jay"

Transportation Asset Management Program

TS-039992 — Transportation Asset Management Program offers a unique bridge condition index (BCI) and management solution for large bridge inventories to be used as a reliable metric and asset management framework.

Transportation infrastructure depends on a robust and well-maintained system of bridges. In the U.S., federal law requires that bridges be inspected once every two years. Some states, including Ohio, require bridges to be inspected every year. One problem with these inspections is that for several…

College: College of Engineering (COE)
Inventors: Shafieezadeh, Abdollah; Hur, Jee-Eun
Licensing Officer: Smith, Richard

Virtual image generation of immunohistochemical stained tissue sections using an artificial neural network

TS-039781 — Realistic immunohistochemical stained tissue section databases for training, certification, and machine standards.

Immunohistochemistry (IHC) is used to determine antigen distribution in a tissue and is widely used for diagnosis of cancers and other diseases. Diagnostic and research laboratories in the United States use locally devised IHC tissue slide preparation and scanning protocols to check scanner perfor…

College: College of Medicine (COM)
Inventors: Gurcan, Metin; Lozanski, Gerard; Senaras, Caglar
Licensing Officer: Norris, Francis "Frank"

Pulse of the OR: Reducing Operating Room Traffic for Patient Safety and Quality Initiatives

TS-039735 — A method of measuring traffic flow in an operating room to reduce contamination and ensure air quality.

Surgical site infections (SSI) can affect all surgical specialties and are an significant cause of long-term morbidity and mortality in the United States. With a rate of 2.8 infections per every 100 operations, these occurrences can lengthen hospital stays, double readmission rates, and can cost b…

College: College of Medicine (COM)
Inventors: Quatman, Carmen; Chaudhari, Ajit
Licensing Officer: Flammang, Ann Marie

Small molecule growth inhibitors of avian pathogenic E. coli (APEC) as a means to control APEC infections in poultry.

TS-039568 — Small molecules have been developed that have shown effective defense against Avian pathogenic Escherichia coli (APEC). These molecules can be used by itself, or with current antibiotics, which helps decrease the overall risk of bacterial antibiotic resistance.

College: College of Food, Agricultural, and Environmental Sciences (CFAES)
Inventors: Rajashekara, Gireesh; Deblais, Loic; Kathayat, Dipak; Mohamed, Yosra
Licensing Officer: Dahlman, Jason "Jay"

Control of Salmonella in poultry using new generation small molecule growth inhibitors

TS-039567 — Small molecule compounds that can be used to inhibit Salmonella growth for safe and sustainable poultry production.

Non-typhoidal Salmonella are among the top five intestinal pathogens in the United States. Among foodborne illnesses, they are responsible for 11% of illnesses, 35% of those hospitalizations, and 28% deaths, with an estimated cost of $3.6 billion in 2014. Poultry is the most common source of wide-…

College: College of Food, Agricultural, and Environmental Sciences (CFAES)
Inventors: Rajashekara, Gireesh; Deblais, Loic; Kathayat, Dipak; Miller, Sally; Mohamed, Yosra
Licensing Officer: Dahlman, Jason "Jay"

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