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Therapeutic uses of the scavenging protein cocktail to treat plasma protein imbalances or depletion
TS-053103 — Uncontrolled hemolysis (i.e., destruction of red blood cells) is characterized by the increase of circulating toxic cell-free hemoglobin, heme and iron in the bloodstream. In vivo, the body’s natural supply of plasma scavenger proteins acts to neutralize these toxic species. However, these scavenger proteins such as haptoglobin, hemopexin and transferrin, which detoxify hemoglobin, heme and iron, respectively, are depleted in various clinical conditions such as hemorrhagic shock, burns, surgery, organ transplantation, sepsis and trauma. Dr. Andre Palmer’s lab at The Ohio State University has developed a novel therapeutic protein mixture, which can be used to treat plasma protein imbalances or depletion caused by the adverse events described above. The properties of this protein mixture are beneficial as they lend themselves to an inexpensive manufacturing process and potential improvements in clinical outcomes.
Fluid replacement as part of resuscitation efforts in clinical care is a cornerstone of treatment especially in cases with severe trauma. The regular usage of these fluids in hospitals requires the mixture to be easily transported, easily stored and applicable across a wide variety of patients. To…
  • College: College of Engineering (COE)
  • Inventors: Susin Pires, Ivan; Cabrales, Pedro; Palmer, Andre
  • Licensing Officer: Davis, Stewart

Method for Preparing High-Energy Electrodes with Controlled Microstructures for Energy-Storage Devices
TS-052586 — A novel method for producing thick electrodes with controlled cracks to facilitate fast ionic transport and improve battery performance.
The Need Conventional electrodes for Li-ion batteries are prepared as thin layers of 70 to 100 microns to meet the power requirements of automotive applications. However, using thin electrodes compromises the energy densities of battery cells due to increasing weight and volume of inactive componen…
  • College: College of Engineering (COE)
  • Inventors: Kim, Jung Hyun; Rao, Lalith; Sayre, Jay
  • Licensing Officer: Bartell, Cordellia

Mobile Harmful Contaminant Detection System: Home Health Kit for the detection of Allergens, Chemicals and Viruses
TS-052249 — A tool for simply and affordably assessing levels of certain household allergens (including asthma triggers), chemical contaminants (formaldehyde) and viruses (including SARS-CoV-2).
The Need Household allergens (including Asthma triggers) Asthma is one of the most common chronic conditions among children in the United States and a major cause of childhood disability. Despite advances in medical treatment, many children have poor asthma control that results in disruptions in s…
  • College: College of Engineering (COE)
  • Inventors: Dannemiller, Karen; Parquette, Jonathan; Qin, Rongjun
  • Licensing Officer: Davis, Stewart

Dynamic Nanobiosensor Platform for Viral and Tumor Nucleic Acid Detection
TS-052072 — A rapid, nucleic acid-based, point-of-care diagnostic.
The current gold-standard molecular diagnostic assay, quantitative reverse transcriptase (RT)-PCR, although accurate, is labor intensive (5-step workflow) and time consuming. Due to centralized laboratory testing, the time to results for RT-PCR can vary from 1 day up to 2 weeks, depending on the s…
  • College: College of Engineering (COE)
  • Inventors: Halley, Patrick; Castro, Carlos; Lucas, Christopher; Marras, Alexander; Shahhosseini, Melika
  • Licensing Officer: He, Panqing

Novel Electrode for Co-factor Regeneration
TS-051995 — Method of regenerating NADPH for the production of biobutanol.
The Need NAD(P)H is used as a reducing co-factor for the synthesis of biochemicals (e.g., conversion of aldehydes to alcohols) using biocatalysts or even microbes. Butanol is an important feedstock used in the chemical industry and shows great potential as a biofuel. Butanol is produced from fossil…
  • College: College of Engineering (COE)
  • Inventors: Kadowaki, Jonathan; Gopalan, Venkat; Jones, Travis; Sengupta, Anindita; Subramaniam, Vishwanath
  • Licensing Officer: Bartell, Cordellia

Novel Ergonomic Scalpel Handle
TS-051663 — Alleviate and prevent occupational stresses using this novel scalpel design.
A highly unfortunate outcome of the 2020 coronavirus pandemic is the over 400,000 American deaths that have unexpectedly overloaded medical autopsy services across the United States. With this heightened need for autopsy services previously unseen occupational hazards relating to repetitive motion…
  • College: College of Medicine (COM)
  • Inventors: Sachire, Jennifer
  • Licensing Officer: He, Panqing

Activation of human Argonaute3 (AGO3) using cityRNAs
TS-051298 — MicroRNAs (miRNAs) are small non-coding RNAs that control gene expression post-transcriptionally. Their sequences differ, but their lengths fall within a range of ~20-23 nucleotides because the precursor miRNAs are processed by Dicer. Dicer cleaves long double-stranded RNA (dsRNA) molecules into s…
  • College: College of Arts & Sciences
  • Inventors: Nakanishi, Kotaro; Park, Mi Seul
  • Licensing Officer: Ezzell, Janel

Modular Dc Circuit Breaker with Integrated Energy Storage for Future Dc Networks
TS-051200 — Traditional AC distribution is not suitable for a wide range of applications in regard to efficiency, cost, and power carrying capacity compared to alternative distributions. Low voltage distribution suffers from high transmission losses due to higher current requirements necessitating thicker, he…
  • College: College of Engineering (COE)
  • Inventors: Wang, Jin; Na, Risha; Zhang, Yue
  • Licensing Officer: Hong, Dongsung

Development of a live attenuated vaccine for leishmaniasis using CRISPR technology
TS-051167 — Methods of production and use of modified Leishmania species and compositions of live, attenuated organisms, immunogenic compositions, vaccines, and pharmaceutical compositions.
Leishmaniasis is a neglected tropical disease caused by infection with protozoans of the 15 genus Leishmania that is transmitted by infected sand flies. Worldwide, an estimated 1 billion people are at risk of infection in tropical and subtropical countries, with up to 1.7 million new cases in 98 c…
  • College: College of Medicine (COM)
  • Inventors: Satoskar, Abhay
  • Licensing Officer: Davis, Stewart

Wireless Identification of Viral Infection (WiVi)
TS-051091 — This invention introduces a novel method for airborne viral pandemic mitigation using WiFi access points as infrastructural spatiotemporal anchors.
New viruses are constantly being discovered. From SARS to Bird Flu, and HIV to COVID-19. The threat of global pandemics is real and methods for tracing and controlling it need to be available. It is necessary that there are capabilities available which can inform the modeling of future viral spre…
  • College: College of Engineering (COE)
  • Inventors: El Gamal, Hesham
  • Licensing Officer: Hong, Dongsung

Concept Discovery from Text via Knowledge Transfer
TS-050856 — A better way for systems to organize, file, or index documents or content based on actual or anticipated information needed in the form of a user query or natural language question.
Data Processing and (IT)-related activities, ranging from web hosting to automated data entry services are more important than ever due to the large amounts of data collected through technology. According to IBIS World, "Companies will increasingly capture more data, requiring the outside exp…
  • College: College of Engineering (COE)
  • Inventors: Das, Manirupa; Fosler-Lussier, John Eric; Ramnath, Rajiv
  • Licensing Officer: Hong, Dongsung

Method of forming low turn on and high breakdown voltage lateral diode.
TS-050626 — A hybrid Schottky and metal/high K dielectric/semiconductor contact to realize higher breakdown and low turn-on voltage for lateral diode based on wide bandgap semiconductors.
Practical realization of high breakdown fields in wide bandgap semiconductors such as GaN, SiC, typically requires the use of p-n junction, which require a turn-on voltage comparable to the bandgap of these semiconductors. For lower voltage applications, the forward or ON-state power loss due to h…
  • College: College of Engineering (COE)
  • Inventors: Rahman, Mohammad Wahidur "Wahidur"; Rajan, Siddharth
  • Licensing Officer: Hong, Dongsung

Method for selective area doping of Gallium Nitride
TS-050625 — A method of selectively obtaining n- and p-type regions from the same III-Nitride layer deposited on a substrate without using diffusion or ion-implantation techniques.
According to IBIS World Reports, manufacturers of electronic components will likely refocus their production away from silicon-based products to wide bandgap (WBG) semiconductors, which are made of materials that have a wider bandgap than silicon. A bandgap, or energy gap, denotes the energy diffe…
  • College: College of Engineering (COE)
  • Inventors: Rajan, Siddharth; Chandrasekar, Hareesh; Rahman, Mohammad Wahidur "Wahidur"
  • Licensing Officer: Hong, Dongsung

Novel acellular vaccine for protection against Bordetella infection
TS-050524 — Despite high vaccine coverage, whooping cough caused by Bordetella pertussis remains one of the most common vaccine-preventable diseases worldwide. Introduction of whole-cell pertussis (wP) vaccines in the 1940s and acellular pertussis (aP) vaccines in 1990s reduced mortality due to pertussis. Des…
  • College: College of Medicine (COM)
  • Inventors: Deora, Rajendar; Mishra, Meenu; Sukumar, Neelima
  • Licensing Officer: He, Panqing

Method for seamless joining and repair of metal parts using ultrasonic additive manufacturing
TS-050479 — This invention provides a method for repairing metal parts by removing and replacing worn, damaged, or defective metal material. It also serves as a method for seamlessly joining metal sheets and other parts while retaining the original temper of the joined parts. This technology, based on ultrasonic additive manufacturing (UAM), achieves strong joints and repairs by enabling the filling of a channel that has been cut, formed, or otherwise created in a metal structure or between two metal structures.
The aircraft industry lacks a robust method for joining metal sheets, structures, and assemblies together in wings, fuselages, and engines. Fusion based welding methods cannot always be used because they create heat-affected zones, which reduce the mechanical performance of material around the wel…
  • College: College of Engineering (COE)
  • Inventors: Dapino, Marcelo; Gingerich, Mark; Headings, Leon
  • Licensing Officer: Zinn, Ryan

Out-of-Plane Fluidic Actuator for Curved Surface Applications
TS-050464 — A novel bistable fluidic actuator design which uses naturally occurring fluid dynamic instabilities instead of moving parts to create an oscillating jet that is out-of-plane from the fluid inlet port.
Turbines are used to produce much of the world’s electricity, whether it be from nuclear, coal, or natural gas sources, as well as provide power for the vast majority of aircraft flying today. For many turbine applications, the first stage vane and blade just downstream of the combustor is a…
  • College: College of Engineering (COE)
  • Inventors: Hossain, Mohammad Arif "Arif"; Ameri, Ali; Bons, Jeffrey; Gregory, James "Jim"
  • Licensing Officer: Zinn, Ryan

Out-of-Plane Fluidic Actuator for Curved Surface Applications
TS-050464 — A novel bistable fluidic actuator design which uses naturally occurring fluid dynamic instabilities instead of moving parts to create an oscillating jet that is out-of-plane from the fluid inlet port.
Turbines are used to produce much of the world’s electricity, whether it be from nuclear, coal, or natural gas sources, as well as provide power for the vast majority of aircraft flying today. For many turbine applications, the first stage vane and blade just downstream of the combustor is a…
  • College: College of Engineering (COE)
  • Inventors: Hossain, Mohammad Arif "Arif"; Ameri, Ali; Bons, Jeffrey; Gregory, James "Jim"
  • Licensing Officer: Zinn, Ryan

Mini-PCDH15 for treatment of deafness
TS-050433 — A gene therapy solution for Usher Syndrome Type 1F.
Mutations in PCDH15 cause Usher 1F, a recessive syndrome characterized by profound congenital deafness and absence of vestibular function, and progressive blindness beginning in the second decade. Because patients who lack hearing and balance rely on vision for communication and mobility, the late…
  • College: College of Arts & Sciences
  • Inventors: Sotomayor, Marcos
  • Licensing Officer: Ezzell, Janel

SARS-CoV-2 Diagnostic Assay with Sensors of Immune Activation
TS-050296 — A sequencing-based diagnostic assay for SARS-CoV-2 with sensors of immune activation and the viral microbiota.
Diagnosis of SARS-CoV-2 infection, which is responsible for COVID-19 disease, is typically performed by molecular analysis of upper respiratory sampling (e.g. nasal swab). Transcriptional-mediated amplification (TMA) and quantitative (real-time) polymerase chain reaction (qPCR) using one or more v…
  • College: College of Medicine (COM)
  • Inventors: Jones, Daniel "Dan"; Avenarius, Matthew; Tu, Huolin
  • Licensing Officer: Davis, Stewart

Smart Platform for Engineered Electroceutical Dressings (SPEEDs) Enables Better Wound Care
TS-050245 — An integrated platform with multiple sensing modalities to actively orchestrate antimicrobial activity and wound healing.
Wound healing and disinfection for chronic wounds presents significant hurdles within the medical industry. Current state of art is inadequate and adds a significant cost burden to the healthcare system with many health and life-quality challenges for patients. After the formation of an open wound…
  • College: College of Engineering (COE)
  • Inventors: Prakash, Shaurya; Heald, Rachel; Mohana Sundaram, Prashanth; Narayanan, Kavya; Stoodley, Paul; Subramaniam, Vishwanath; Vilku, Gurleen; Wilgus, Traci; Wozniak, Daniel
  • Licensing Officer: Hong, Dongsung

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