Motion-Guided Deep Image Prior (M-DIP) for Dynamic Image Reconstruction in Cardiovascular MRI
TS-069527 — The Need
Cardiovascular MRI (CMR) data acquisition is often time-consuming and relies on complex reconstruction methods that do not fully exploit the spatial and temporal structure of CMR data. There is a need for a more efficient, unsupervised approach that can accelerate CMR imaging while maintai…
- College: College of Engineering (COE)
- Inventors: Ahmad, Rizwan; Chen, Chong; Sultan, Muhammad
- Licensing Officer: Randhawa, Davinder
Neonatal Blood Vessel Locator for Vascular Access Procedures
TS-067796 — A handheld device for identifying preterm blood vessels in neonatal ICU.
Over 300,000 preterm births in the United States occur annually, representing 10.5% of all live births. Most preterm births occur spontaneously, but some result from medical conditions like infections or pregnancy complications requiring early labor induction or cesarean delivery. Common causes of p…
- College: College of Engineering (COE)
- Inventors: Metzler, Sandra; Bresolin, Alejandro; Crawford, Mackenzie; Fernandes, Siddharth; Hardin, Rene; Patel, Aarti; Richards, Hannah; Trainor, Dylan
- Licensing Officer: Zinn, Ryan
Small Molecule USP30 Inhibitors for the Treatment and Prevention of Cardiomyopathy
TS-066773 — The Need
Cardiomyopathy, a disease of the heart muscle, poses significant public health challenges due to its diverse causes, symptoms, and potential complications, including heart failure and arrhythmias. With cardiomyopathy often induced by drugs, such as anthracyclines used in chemotherapy, ther…
- College: College of Medicine (COM)
- Inventors: Sun, Nuo; Krigman, Judith; Yang, Mingchong; Zhang, Ruohan
- Licensing Officer: Willson, Christopher
Protecting the vascular endothelial barrier – a novel approach to treating atrial fibrillation
TS-063433 — A new pharmacologic modality for treating AFib.
Atrial fibrillation (AF) is the most common form of irregular cardiac rhythm (arrhythmia), affecting approximately 3% of the US population. It is a significant risk factor for heart failure, ischemic stroke, and sudden cardiac death. The AF mortality rate is growing globally, and risk factors known …
- College: College of Engineering (COE)
- Inventors: Veeraraghavan, Rengasayee; Mezache, Louisa
- Licensing Officer: Willson, Christopher
Gene Therapy Compositions for Treating Cardiovascular Diseases
TS-063091 — A gene therapy approach to address the specific needs of failing hearts.
Heart failure affects over 6 million adults in the US and can lead to irreversible damage to the heart.
The Need
In the realm of cardiovascular health and the management of heart-related disorders, there exists a pressing commercial need for a technology that can effectively address the challenge…
- College: College of Medicine (COM)
- Inventors: Lewandowski, E. Douglas; Carley, Andrew
- Licensing Officer: Willson, Christopher
Localized Cylindrical Drug Delivery to Prevent Vascular Restenosis
TS-062216 — The Need: Addressing Vascular Restenosis with Extended Drug Delivery
Vascular restenosis poses a significant medical challenge in the United States, particularly in cases of coronary artery disease treated with bypass grafting. The current methods involve using drug-loaded polymer formulations to d…
- College: College of Engineering (COE)
- Inventors: Lannutti, John
- Licensing Officer: Dahlman, Jason "Jay"
Treating Obesity and Cardiovascular Disease Via Genetic Manipulation of Skin Tissue
TS-062096 — Using tissue nano-transfection to regulate BAT and increase 12,13-diHOME production to treat obesity, cardiovascular disease and type 2 diabetes.
Cardiovascular disease (CVD) is the leading cause of death across the US and worldwide and affects almost half of all adults in the US. CVD encompasses a number of conditions that affect the heart and vasculature. CVD can arise in response to multiple factors, including obesity. Obesity elevates the…
- College: College of Medicine (COM)
- Inventors: Stanford, Kristin; Gallego Perez, Daniel; Ziolo, Mark
- Licensing Officer: Willson, Christopher
An AI Solution for Mobile Stroke Detection for TeleMedicine, Hospital and Paramedic Use
TS-060782 — Problem Statement:
Diagnosis of arterial occlusion and an associated stroke can be lengthy, delaying patient access to treatment. As large vessel occlusions account for 24 to 46% of acute ischemic strokes and may require treatment in a comprehensive stroke center, early diagnosis is key.
Solution:…
- College: College of Engineering (COE)
- Inventors: Yilmaz, Alper; Gulati, Deepak Kumar
- Licensing Officer: Hampton, Andrew
Perivascular Drug Delivery Nanoplatform for Preventing Restenosis After Open Surgery
TS-039004 — Pericelle: a nanoparticle based perivascular drug delivery system to prevent stenosis and failure in vascular reconstruction surgeries.
Imaging and re-intervention procedures, necessary to maintain open blood vessels following vascular reconstruction surgery, are expensive. For example, the cost of maintenance for an arteriovenous (AV) fistula used in hemodialysis access has been estimated at $15,000/year. In bypass and AV fistula…
- College: College of Medicine (COM)
- Inventors: Kent, K. Craig; Chen, Guojun; Gong, Shaoqin; Guo, Lianwang; Shi, Xudong
- Licensing Officer: Taysavang, Panya
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