Method for sensitizing solid tumors to immunotherapy

The Need

In the landscape of cancer treatment, the emergence of immunotherapy has shown remarkable promise. However, its efficacy is not universal across all cancer types, and resistance development poses a significant challenge. Hyperprogression, characterized by accelerated tumor growth, further complicates matters. Addressing these hurdles is crucial for advancing cancer therapy and improving patient outcomes.

The Technology

Tumor sensitization technology targets the mechanisms underlying resistance to immunotherapy. This approach aims to enhance the efficacy of existing immunotherapies, such as immune checkpoint inhibitors, by either directly influencing cancer cells or modifying the tumor microenvironment. By sensitizing tumors to immunotherapy, this technology seeks to overcome resistance and mitigate the risk of hyperprogression, ultimately improving treatment outcomes.

Commercial Applications

  • Enhancing the efficacy of immune checkpoint inhibitors in various cancer types
  • Combating drug resistance and reducing the likelihood of hyperprogression
  • Expanding the applicability of immunotherapy to previously refractory tumors
  • Improving patient response rates and long-term survival outcomes
  • Facilitating combination therapies for synergistic effects in cancer treatment


  • Increases the effectiveness of existing immunotherapies
  • Reduces the incidence of treatment resistance and hyperprogression
  • Broadens the therapeutic potential of immunotherapy across diverse cancer types
  • Enhances patient outcomes by improving response rates and prolonging survival
  • Provides opportunities for innovative combination treatments to maximize efficacy

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