Endothelial Biomarkers for Detecting Neurological Diseases
TS-075259 — More than a billion people worldwide suffer from some form of neurological disorder, such as Alzheimer's (AD), Parkinson's (PD), multiple sclerosis, traumatic brain injury, epilepsy, stroke, or spinal injury. These conditions result in more than 7 million deaths, with associated costs exceed…
- College: College
of
Medicine
(COM)
- Inventors: Al Tarawneh, Rawan
- Licensing Officer: Willson, Christopher
Compositions and Methods for Treating Neurological Disorders
TS-075255 — Problem
The limited regenerative capacity of adult CNS neurons upon transection results in chronic neurological disability. There is an urgent need to develop novel therapies that facilitate CNS axon regeneration and ultimately restore lost neurological functions.
Solution
Applications
Advan…
- College: College
of
Medicine
(COM)
- Inventors: Segal, Benjamin; Sas, Andrew
- Licensing Officer: Bhatti, Hamid
Biomarker for peripheral neuropathy
TS-075246 — Problem
Peripheral neuropathy, especially small fiber neuropathy, is a debilitating condition that affects millions and is commonly linked to aging, diabetes, and metabolic disorders. Existing diagnostic tools are often invasive, expensive, or they lack the sensitivity to detect early disease stage…
- College: College
of
Medicine
(COM)
- Inventors: Townsend, Kristy; Blaszkiewicz, Magdalena; Gunsch, Gilian; Segal, Benjamin; Willows, Jake
- Licensing Officer: Willson, Christopher
Immune Based Neuroprotective and Neuroregenerative Therapies
TS-075243 — Problem
Central nervous system (CNS) injury can result in permanent neurological disability and vision loss. There is a dire need to develop novel therapies that overcome barriers to repair within the CNS and promote neuron survival and axon regeneration.
Solution
Applicat…
- College: College
of
Medicine
(COM)
- Inventors: Segal, Benjamin; Jerome, Andrew; Liu, Tom; Sas, Andrew
- Licensing Officer: Bhatti, Hamid
Targeting ERβ with a novel agonist in the treatment of peripheral neuropathies and metabolic disease
TS-075181 — PROBLEM
Metabolic diseases and peripheral neuropathies represent a major public health burden in the United States, and the risks increase as we age. Metabolic diseases, including diabetes and obesity, and peripheral neuropathy (PN) affect approximately 25-45% and 10-20% of U.S. adults aged 50-70 r…
- College: College
of
Medicine
(COM)
- Inventors: Townsend, Kristy
- Licensing Officer: Willson, Christopher
Gene therapy for adipose neuropathy
TS-075160 — Problem
Peripheral neuropathy (PN) results in loss of innervation by the peripheral nerves in tissues such as skin, muscle, heart and subcutaneous white adipose tissue (scWAT). It is mostly associated with diabetes, obesity, aging, and chemotherapy. Affecting 10-20% of U.S. adults aged 50-70, PN is…
- College: College
of
Medicine
(COM)
- Inventors: Townsend, Kristy; Blaszkiewicz, Magdalena; Cao, Lei
- Licensing Officer: Willson, Christopher
Innovative Biomarker Technology for Detecting and Treating Endothelial Injury in Neurological Disorders
TS-066771 —
Endothelial injury is a significant pathological mechanism underlying various neurological disorders, including neurodegenerative, neuroinflammatory, and cerebrovascular diseases. Current clinical and research settings lack reliable biomarkers to detect or measure endothelial injury in the human C…
- College: College
of
Medicine
(COM)
- Inventors: Al Tarawneh, Rawan
- Licensing Officer: Willson, Christopher
Gene Therapy Approach for Treating Neuropathy
TS-065913 — Gene therapy strategies for treating peripheral neuropathy.
Peripheral neuropathy (PN) results in loss of innervation by the peripheral nerves in tissues such as skin, muscle, heart, and adipose tissue. It is a painful, debilitating disease, that is estimated to affect between 20 and 30 million Americans. The number of Americans affected by PN is likely muc…
- College: College
of
Medicine
(COM)
- Inventors: Townsend, Kristy; Blaszkiewicz, Magdalena; Cao, Lei
- Licensing Officer: Willson, Christopher
A Breakthrough in Central Nervous System Repair
TS-062739 — Method to program pericytes for axon regeneration and spinal cord injury repair.
In the realm of central nervous system (CNS) repair, a critical need arises for innovative treatments that not only address the physical aspects of injury but also tackle the associated phychopathology. Understanding the cellular processes that occur after spinal cord injury (SCI) that are detrimen…
- College: College
of
Medicine
(COM)
- Inventors: Tedeschi, Andrea
- Licensing Officer: Willson, Christopher
Revolutionizing Vascular Access Management for Hemodialysis Patients
TS-062693 — Dynamic AVF flow control: A paradigm shift in vascular access management for hemodialysis patients.
Patients with end-stage renal disease (ESRD) undergoing hemodialysis (HD) face critical challenges in maintaining functional vascular access. Despite the superiority of arteriovenous fistulas (AVFs) in terms of longevity, infection rates, and cost-effectiveness, over a third of AVFs fail to mature a…
- College: College
of
Medicine
(COM)
- Inventors: Boubes, Khaled
- Licensing Officer: Bhatti, Hamid
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