Endothelial Biomarkers for Detecting Neurological Diseases
TS-075259 — More than a billion people worldwide suffer from some form of neurological disorder, such as Alzheimer's (AD), Parkinson's (PD), multiple sclerosis, traumatic brain injury, epilepsy, stroke, or spinal injury. These conditions result in more than 7 million deaths, with associated costs exceed…
- College: College of Medicine (COM)
- Inventors: Al Tarawneh, Rawan
- Licensing Officer: Willson, Christopher
Biomarker for peripheral neuropathy
TS-075246 — Problem
Peripheral neuropathy, especially small fiber neuropathy, is a debilitating condition that affects millions and is commonly linked to aging, diabetes, and metabolic disorders. Existing diagnostic tools are often invasive, expensive, or they lack the sensitivity to detect early disease stage…
- College: College of Medicine (COM)
- Inventors: Townsend, Kristy; Blaszkiewicz, Magdalena; Gunsch, Gilian; Segal, Benjamin; Willows, Jake
- Licensing Officer: Willson, Christopher
Targeting ERβ with a novel agonist in the treatment of peripheral neuropathies and metabolic disease
TS-075181 — PROBLEM
Metabolic diseases and peripheral neuropathies represent a major public health burden in the United States, and the risks increase as we age. Metabolic diseases, including diabetes and obesity, and peripheral neuropathy (PN) affect approximately 25-45% and 10-20% of U.S. adults aged 50-70 r…
- College: College of Medicine (COM)
- Inventors: Townsend, Kristy
- Licensing Officer: Willson, Christopher
Gene therapy for adipose neuropathy
TS-075160 — Problem
Peripheral neuropathy (PN) results in loss of innervation by the peripheral nerves in tissues such as skin, muscle, heart and subcutaneous white adipose tissue (scWAT). It is mostly associated with diabetes, obesity, aging, and chemotherapy. Affecting 10-20% of U.S. adults aged 50-70, PN is…
- College: College of Medicine (COM)
- Inventors: Townsend, Kristy; Blaszkiewicz, Magdalena; Cao, Lei
- Licensing Officer: Willson, Christopher
Innovative Biomarker Technology for Detecting and Treating Endothelial Injury in Neurological Disorders
TS-066771 —
Endothelial injury is a significant pathological mechanism underlying various neurological disorders, including neurodegenerative, neuroinflammatory, and cerebrovascular diseases. Current clinical and research settings lack reliable biomarkers to detect or measure endothelial injury in the human C…
- College: College of Medicine (COM)
- Inventors: Al Tarawneh, Rawan
- Licensing Officer: Willson, Christopher
Gene Therapy Approach for Treating Neuropathy
TS-065913 — Gene therapy strategies for treating peripheral neuropathy.
Peripheral neuropathy (PN) results in loss of innervation by the peripheral nerves in tissues such as skin, muscle, heart, and adipose tissue. It is a painful, debilitating disease, that is estimated to affect between 20 and 30 million Americans. The number of Americans affected by PN is likely muc…
- College: College of Medicine (COM)
- Inventors: Townsend, Kristy; Blaszkiewicz, Magdalena; Cao, Lei
- Licensing Officer: Willson, Christopher
A Breakthrough in Central Nervous System Repair
TS-062739 — Method to program pericytes for axon regeneration and spinal cord injury repair.
In the realm of central nervous system (CNS) repair, a critical need arises for innovative treatments that not only address the physical aspects of injury but also tackle the associated phychopathology. Understanding the cellular processes that occur after spinal cord injury (SCI) that are detrimen…
- College: College of Medicine (COM)
- Inventors: Tedeschi, Andrea
- Licensing Officer: Willson, Christopher
Nanobody-based Protein Degraders for the Treatment of Neurodegenerative Diseases
TS-062678 — Neurodegenerative diseases including Alzheimer's and Parkinson’s diseases, amyotrophic lateral sclerosis (ALS), prion diseases, and among others affect millions of people in the US. These diseases are relentless, often fatal, and affect fundamental functions – things like moving, bre…
- College: College of Medicine (COM)
- Inventors: Chu, Nam; Le, Nhat
- Licensing Officer: Willson, Christopher
Drug Delivery System for the Treatment of Neurological Diseases
TS-054464 — Novel drug delivery system that enables efficient transfer of FDA-approved drugs for the treatment of neurological injuries.
Traumatic brain and spinal cord injury cause devastating neurological deficits and long-term disability due to detrimental structural and functional alteration in neuronal circuits. Treatment of brain injury and neurological disorders has traditionally been challenging due to the inability to deli…
- College: College of Engineering (COE)
- Inventors: Lannutti, John; Fan, Fan; Tedeschi, Andrea
- Licensing Officer: Willson, Christopher
