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Antibiotic-free selection of plasmids for recombinant DNA technology applications
TS-065461 — The Need: In the field of modern biochemistry, the production of recombinant proteins in bacterial hosts like Escherichia coli is integral for both research and industrial applications. However, the traditional method of using antibiotics for selection in protein production is costly and contributes…
  • College: College of Arts & Sciences
  • Inventors: Gopalan, Venkat
  • Licensing Officer: Willson, Christopher

Targeted Nanobody Technology for Precise Antineoplastic Treatment
TS-065460 — The Need Cancer remains one of the most pressing medical challenges worldwide, necessitating novel therapeutic approaches to combat its proliferation. Despite advancements, targeted therapies are often limited by immune responses or cumbersome production processes. There's a growing demand for …
  • College: College of Arts & Sciences
  • Inventors: Magliery, Thomas; Palmieri, Dario; Ryan-Simkins, Michael
  • Licensing Officer: Willson, Christopher

Peptide-based inhibitor of host factor involved in HIV-1 replication
TS-065459 — The Need The emergence of HIV-1 infection continues to pose significant challenges in healthcare worldwide. Current treatment approaches primarily target viral components, leading to the development of drug resistance over time. There is a pressing need for innovative therapeutic strategies that di…
  • College: College of Arts & Sciences
  • Inventors: Musier-Forsyth, Karin; Tang, Yingke
  • Licensing Officer: Willson, Christopher

Precision RNA-PROTACs: Revolutionizing Therapeutic Targeting of Dysregulated Ribonucleoprotein Complexes
TS-065457 — The Need: In the realm of therapeutic development, there's a pressing need for precise targeting of dysregulated ribonucleoprotein (RNP) complexes to combat various diseases, particularly neurodegenerative disorders like ALS, Alzheimer’s, and Huntington’s diseases. Traditional metho…
  • College: College of Arts & Sciences
  • Inventors: Bong, Dennis; Liang, Yufeng; Miao, Shiqin "Shiqin"; Strong, Rebekah
  • Licensing Officer: Willson, Christopher

Revolutionizing RNA-Protein Interaction Mapping: Precision Proximity Labeling Technology
TS-065456 — The Need In modern biological research, there is a pressing demand for technologies that enable precise mapping of RNA-protein interactions within Ribonucleoprotein (RNP) complexes. Traditional methods often lack the capability to pinpoint these interactions at the level of secondary structure moti…
  • College: College of Arts & Sciences
  • Inventors: Bong, Dennis; Liang, Yufeng; Miao, Shiqin "Shiqin"
  • Licensing Officer: Willson, Christopher

Advancing RNA Detection with Innovative Peptide-Based Fluorescent Probes
TS-065455 — The Need: In modern biotechnology and biomedical research, there is an escalating demand for efficient tools that can accurately detect and analyze specific RNA sequences. The ability to precisely target and identify RNA molecules, particularly U-rich sequences, is crucial for various applications s…
  • College: College of Arts & Sciences
  • Inventors: Bong, Dennis; DeSantis, Christopher; Gopalan, Venkat; Liang, Yufeng; Mao, Jie; Marathe, Ila; Miao, Shiqin "Shiqin"
  • Licensing Officer: Willson, Christopher

Quantum Leap: Revolutionizing Computing and Sensing with Modular Zero-Dimensional Tunnel Junction Devices
TS-065414 — The Need: Innovations in the field of quantum technology are paramount to addressing the escalating demand for advanced computational capabilities and sensitive sensor applications. As traditional computing methodologies reach their limits, there arises an urgent commercial need for breakthroughs i…
  • College: College of Arts & Sciences
  • Inventors: Johnston-Halperin, Ezekiel; Gupta, Jay; Hamilton, Morgan; Kavand, Marzieh; Koll, Will; Perez-Hoyos, Ethel; Phillips, Zoe
  • Licensing Officer: Willson, Christopher

IR Precision: Revolutionizing Colorectal Cancer Metastasis Diagnosis with the CCML Library
TS-064834 — The Need: Colorectal cancer remains a significant global health challenge, particularly when it metastasizes to the liver. Accurate and rapid diagnosis of metastatic liver lesions is crucial for effective treatment planning and patient outcomes. Traditional diagnostic methods often lack the specific…
  • College: College of Arts & Sciences
  • Inventors: Coe, James; Allen, Heather; Bradley, Rebecca; Hitchcock, Charles; Martin, Edward
  • Licensing Officer: Willson, Christopher

Machine Learning Aided Concentration Prediction of Organic Compounds in the Sea Surface Microlayer by Vibrational Spectroscopic Methods
TS-064832 — The Need: The chemical composition of the sea surface microlayer (SSML) plays a crucial role in various environmental processes, impacting atmospheric chemistry and oceanic dynamics. However, traditional analytical methods struggle to efficiently characterize the complex and variable composition of …
  • College: College of Arts & Sciences
  • Inventors: Allen, Heather; Enders, Abigail; North, Nicole
  • Licensing Officer: Willson, Christopher

Intracellular Targeting by Monoclonal Antibodies
TS-064581 — Antibodies are essential therapeutic modalities for treating a plethora of different diseases, ranging from cancer, autoimmune disorders, degenerative diseases, and inflammation. The FDA approved the first antibody over three decades ago, and since more than 570 have been studied in clinical trials,…
  • College: College of Arts & Sciences
  • Inventors: Magliery, Thomas; Do, Jamie; Han, Jeong Min "Mina"; Zhu, Ian
  • Licensing Officer: Willson, Christopher

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