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Saccharide Based RAFT Agents: Enabling the Next Generation of Biocompatible Smart Polymers
TS-075519 — A galactose-based RAFT chain transfer agent (Gal-RAFT) that incorporates a sugar moiety at the polymer terminus, enabling the synthesis of well-defined polymers with an integrated carbohydrate handle for subsequent biological applications.
Overview Most commercial RAFT agents are designed for polymerization control, including but not limited to chain length, architecture, and dispersity, and lack biologically relevant functionality for advanced drug delivery and targeting. Hence, incorporating a targeting molecule requires separate …
  • College: College of Arts and Sciences (ASC)
  • Inventors: Kulkarni, Anuja; Watkins, Davita
  • Licensing Officer: Panic, Ana

ElectroTag Diagnostics
TS-074316 — Pre‑Launch Start‑Up Opportunity: Seeking Business Leads ElectroTag is a multiplex diagnostics platform that enables simultaneous measurement of multiple disease‑associated proteins from a small patient sample. The system replaces conventional color‑based labels with mass‑encoded peptide tags that are read by mass spectrometry, delivering higher analytical specificity and a clear path to expanding from small to large biomarker panels while maintaining streamlined workflows.
Technology Overview Clinical and research laboratories are increasingly adopting multi‑marker panels to improve diagnosis, guide therapy selection, and monitor treatment response. Traditional formats such as ELISA plates and lateral flow strips rely on optical or enzymatic signals, which begin to…
  • College: College of Arts and Sciences (ASC)
  • Inventors: Badu-Tawiah, Abraham; Seth, Ayesha; Zerrudo, Stephanee
  • Licensing Officer: Panic, Ana

Novel HIV Targeting Strategy for Next‑Generation Antivirals
TS-074218 — This HIV-focused technology introduces a novel strategy for engaging conserved viral biology that is not directly addressed by existing antiretroviral classes. By expanding the range of actionable HIV mechanisms, the approach creates new opportunities for therapeutic discovery, combination strategies, and next‑generation intervention concepts. The technology is designed to complement current HIV treatment paradigms while supporting diversification of long‑term antiviral pipelines.
Technology Overview This HIV-focused technology introduces a novel strategy for engaging conserved viral biology that is not directly addressed by existing antiretroviral classes. By expanding the range of actionable HIV mechanisms, the approach creates new opportunities for therapeutic discove…
  • College: College of Arts and Sciences (ASC)
  • Inventors: Musier-Forsyth, Karin; Kelley, Elise; Nielsen, Andrew
  • Licensing Officer: Panic, Ana

Cyclic Cell-Penetrating Peptides: Revolutionizing Intracellular Delivery
TS-073895 — The Need In the rapidly evolving field of biotechnology and pharmaceuticals, there is a critical need for efficient delivery mechanisms to transport therapeutic agents directly into cells. Cell-penetrating peptides (CPPs) initially were considered a potential solution. Short sequences of amino acid…
  • College: College of Arts and Sciences (ASC)
  • Inventors: Pei, Dehua
  • Licensing Officer: Dahlman, Jason "Jay"

Breakthrough In Delivery: Expanding Access to Intracellular Targets for Next-Generation Therapies
TS-072004 — Empower your pipeline with a versatile platform for efficient, customizable biomolecule transport.
Overview Intracellular delivery remains a persistent challenge in drug delivery, gene editing, and biotechnology. Pharmaceutical and biotech companies lose valuable opportunities when promising drugs and biologics cannot reach their intended targets inside cells, limiting product effectiveness and m…
  • College: College of Arts and Sciences (ASC)
  • Inventors: Bong, Dennis
  • Licensing Officer: Panic, Ana

NucNano: Predictive Drug Screening Platform
TS-071946 — Mechanistic drug screening technology to improve preclinical decision-making and reduce late-stage development risk.
Technology Summary NucNano is an emerging drug screening platform from The Ohio State University designed to help pharmaceutical and biotechnology companies identify more promising therapeutic candidates earlier in development. By moving beyond conventional assays that primarily measure bindin…
  • College: College of Arts and Sciences (ASC)
  • Inventors: Poirier, Michael; Bonin, Kalven; Bundschuh, Ralf; Castro, Carlos
  • Licensing Officer: Panic, Ana

Instant Diagnostics, Anywhere
TS-070543 — A Handheld Diagnostics Platform for Point of Care Rapid Diagnostics
The diagnostics market faces pressure for faster and more reliable solutions that can access even the most remote of locations due to global health challenges. Existing diagnostic technologies require health care providers to choose between cost and diagnostic accuracy. Scalable multiplex biomarke…
  • College: College of Arts and Sciences (ASC)
  • Inventors: Badu-Tawiah, Abraham; Seth, Ayesha; Zerrudo, Stephanee
  • Licensing Officer: Panic, Ana

A new modular format for bispecific antibody fragments
TS-068425 — Functionalization of scFvs with cyclic peptide linkers
The Need The high specificity of antibodies has been utilized to develop numerous technologies, tools and therapeutics, like ADCs and radiopharmaceuticals. Engineered antibody fragments like single-chain variable fragments (scFvs) are starting to see their way into the clinic in BiTEs and CAR T. Sc…
  • College: College of Arts and Sciences (ASC)
  • Inventors: Magliery, Thomas; Do, Jamie; Han, Jeong Min "Mina"; Zhu, Ian
  • Licensing Officer: Panic, Ana

Noninvasive Rapid Radiation Exposure Assay
TS-068290 — The Need Radiation exposure poses significant health risks, including cancer and other illnesses, making it crucial for clinicians to accurately measure and assess the extent of radiation exposure. Existing methods often require invasive procedures and may not detect exposure at lower dose ranges. …
  • College: College of Arts and Sciences (ASC)
  • Inventors: Schultz, Zachary; Jacob, Naduparambil; Morder, Courtney; Witte, Spencer
  • Licensing Officer: Panic, Ana

RAFT Agents for Controlled Radical Polymerization of Biofunctionalized Polymeric Materials
TS-068081 — These RAFT agents enable synthesis of novel polymer materials with enhanced biocompatibility and tailored functionality, suited for a wide range of biomedical applications.
Background The growing demand for biofunctionalized polymer materials in fields such as drug delivery and diagnostics requires precise control over polymer properties. However, current reagents for Reversible Addition Fragmentation chain Transfer (RAFT) polymerization struggle with achieving the ne…
  • College: College of Arts and Sciences (ASC)
  • Inventors: Kulkarni, Anuja; Watkins, Davita
  • Licensing Officer: Panic, Ana

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