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Lipolysis-stimulated lipoprotein receptor (LSR)-targeted mAb and ADC for LSR+ tumors treatment
TS-075185 — Problem The lipolysis-stimulated lipoprotein receptor (LSR) is a promising target for cancer therapy. LSR is overexpressed in many tumor tissues with metastatic signatures such as breast, gastric, and endometrial cancer. LSR expression levels may serve as prognostic indicators and help stratify pat…
  • College: College of Engineering (COE)
  • Inventors: Liu, X. Margaret; Zhou, Zhuoxin; Zhou, Lufang
  • Licensing Officer: Schworer, Adam

Cancer mitochondria-targeted luminoptogenetics (mLumiOpto) to treat GBM and metastatic cancers
TS-075179 — Problem Mitochondria is a promising target for cancer treatment. However, current strategies to specifically and effectively destroy cancer mitochondria in vivo are limited. Solution Applications Competitive Advantages Seeking Opportunities for Licensing and collaboration
  • College: College of Engineering (COE)
  • Inventors: Liu, Xiaoguang "Margaret"; Zhou, Lufang
  • Licensing Officer: Schworer, Adam

Humanized somatostatin receptor 2 (SSTR2) mAb and ADCs to target SSTR2+ tumors
TS-075165 — Problem Neuroendocrine tumors (NETs) are often metastatic at diagnosis, thus limiting surgical options. Chemotherapies offer limited efficacy and high toxicity. Meningiomas, though usually benign, are the most common intracranial tumors. Both NETs and meningiomas overexpress SSTR2, making it a prom…
  • College: College of Engineering (COE)
  • Inventors: Liu, Xiaoguang "Margaret"; Zhou, Lufang
  • Licensing Officer: Schworer, Adam

Humanized SSTR2 mAb and ADC to target SSTR2+ tumors
TS-066912 — Targeted humanized mAbs and ADCs for cancer treatment
The Liu Lab Dr. Xiaoguang “Margaret” Liu applies her industry experience (Lonza, Merck, and Life Technologies) in cell line and process development towards her lab’s focus on targeted anti-cancer therapies including monoclonal antibodies, antibody-drug conjugates, and gene therapi…
  • College: College of Engineering (COE)
  • Inventors: Liu, Xiaoguang "Margaret"; Zhou, Lufang
  • Licensing Officer: Schworer, Adam

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