Available Technologies
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Applied Category Filter (Click To Remove): Small Molecules
Targeted molecules for the treatment of cancer
TS-038027 — Novel dihdroorotate dehydrogenase (DHODH) small-molecule inhibitors for the treatment of Acute Myeloid Leukemia, Multiple Myeloma, & Graft vs. Host Disease / Leukemia.
DHODH is a rate-limiting enzyme in de novo pyrimidine synthesis. Rapidly dividing cancer cells are therefore sensitive to blockade of this pathway. New research has shown DHODH inhibition can induce differentiation in acute myeloid leukemia (AML) cell lines, translating to increased survival in an…
- College: College of Medicine (COM)
- Inventors: Byrd, John; Abdulrahim, Mouad; Elgamal, Ola; Goodwin, Thomas; Hertlein, Erin; Ravikumar, Pratheepa; Shah, Dimple
- Licensing Officer: Schworer, Adam
Novel Protein Kinase C Delta Activators
TS-014754 — A novel anti-cancer agent (OSU-2S) that is devoid of S1P1 receptor activity and is highly effective in suppressing hepatocellular carcinoma tumor growth in vivo.
The third leading cause of cancer death worldwide is hepatocellular carcinoma (HCC). Due to the rise in the incidence of hepatitis C virus infection, HCC is expected to increase in the United States. Many patients with HCC are not candidates for surgery because of the location or size of their tum…
- College: College of Pharmacy
- Inventors: Chen, Ching-Shih; Byrd, John; Kulp, Samuel; Muthusamy, Natarajan; Wang, Dasheng
- Licensing Officer: Taysavang, Panya
