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Suppressing background carbon incorporation using laser-assisted MOCVD growth of nitride-based semiconductors
TS-063717 — The Need In the world of semiconductor material systems, the demand for advancements in optoelectronic and power electronic devices is ever-growing. The fabrication of semiconductor films, crucial for these applications, primarily relies on epitaxy technologies such as hydride vapor phase epitaxy (…
  • College: College of Engineering (COE)
  • Inventors: Zhao, Hongping; Chen, Zhaoying; Zhang, Yuxuan
  • Licensing Officer: Randhawa, Davinder

Grass Surrogate
TS-062844 — Road departure is a serious threat to vehicle safety and can result in fatal accidents. To prevent road departure, some vehicles are equipped with a road departure mitigation system that can detect when a vehicle is about to leave the road and take corrective actions. However, there is a need for …
  • College: College of Engineering (COE)
  • Inventors: Chen, Chi-Chih
  • Licensing Officer: Zinn, Ryan

A Novel MIMO Architecture for Multi-user Power line communication
TS-062843 — This MIMO-PLC architecture is the first scalable MIMO architecture on a single power line. It improves the throughput for power line communication (PLC) by utilizing the existing power delivery infrastructure and allows for high data rates in rural areas.
Home networking and the Internet of Things (IoT), especially voice and video communications, require high throughput, reliable coverage, and sustainable connectivity. However, the performance is dramatically decreased when the wireless signals go through the walls and ceilings. The densely deploye…
  • College: College of Engineering (COE)
  • Inventors: Srinivasan, Kannan; Chen, Bo; Guruvenkata, Vivek; Sun, Wei
  • Licensing Officer: Phillips, Taylor

Transducin β-like protein 1 X-Linked Selective Degraders as Anti-cancer Therapeutics
TS-062685 — Cancer is a leading cause of death worldwide, accounting for nearly 10 million deaths in 2020, or nearly one in six deaths. The most common cancers are breast, lung, colon and rectum and prostate cancers. The Need Current cancer treatments mainly rely on chemotherapy, radiation, surgery and bon…
  • College: College of Pharmacy
  • Inventors: Cheng, Xiaolin; Alinari, Lapo; Li, Pui-Kai "Tom"; Yang, Rui
  • Licensing Officer: Taysavang, Panya

Advanced AAV Gene Therapy Characterization Technique
TS-062608 — Gene therapy is an emerging technology that replaces a faulty gene or adds a new gene to cure disease or improve your body's ability to fight infection. These next-generation treatments hold promise for treating various genetic and chronic conditions, including but not limited to cancer, cystic …
  • College: College of Arts & Sciences
  • Inventors: Wysocki, Vicki; Cleary, Sean; Du, Chen
  • Licensing Officer: Dahlman, Jason "Jay"

Small molecules that reduce the bitter properties of food and beverages
TS-062218 — The Need: Flavor Modulating Compounds for Healthier Food and Beverages In a world where taste preferences drive consumer choices, the demand for nutritious and palatable food and beverages remains at an all-time high. However, many nutrient-rich foods, such as vegetables and whole grains, often possess bitter flavors that can be unappealing to consumers. To make these foods more enjoyable and mask the bitterness, manufacturers frequently resort to excessive amounts of unhealthy additives like fats, sugars, and salts. The result is a trade-off between taste and health, leaving consumers seeking a solution that provides both flavor satisfaction and nutritional benefits. The Technology: Innovative Flavor Modulating Compounds Our technology offers a groundbreaking solution to the challenge of balancing taste and health in food and beverages. Developed as additives for the food industry, our flavor modulating compounds effectively block or modulate bitter flavors, enabling significant reductions in the need for added sugars and salts. By utilizing these compounds, manufacturers can maintain the palatability of their products without compromising on nutritional value. Commercial Applications: Unlocking the Potential The versatility of our flavor modulating compounds opens up numerous commercial applications across various food and beverage categories: Healthy Snacks: Create nutritious and appealing snacks using bitter-rich ingredients, like vegetable chips and whole grain crackers, while minimizing the need for excessive unhealthy additives. Low-Sugar Beverages: Develop refreshing drinks with reduced sugar content, ensuring that consumers enjoy a satisfying taste experience without the guilt of excess sugar consumption. Nutrient-Enhanced Foods: Enhance the flavor profile of nutrient-rich foods, such as salads and soups, to make them more enjoyable, encouraging healthier eating habits. Confectionery: Improve the taste of health-focused sweets and candies, enabling confectionery brands to cater to health-conscious consumers. Ready-to-Eat Meals: Incorporate flavor modulating compounds into pre-packaged meals, enhancing taste while adhering to nutritional guidelines. Benefits/Advantages: Elevating Consumer Experience and Market Appeal Our flavor modulating compounds offer an array of advantages for food and beverage manufacturers, making them a valuable addition to any product development strategy: Healthier Product Profiles: Enable the creation of low-sugar, low-salt products, supporting consumer health and well-being. Uncompromised Taste: Maintain delicious flavor profiles while reducing or eliminating unhealthy additives, satisfying consumer cravings. Market Differentiation: Stand out in a crowded market by offering healthier alternatives without sacrificing taste. Health-Conscious Appeal: Attract health-conscious consumers seeking better-for-you options, expanding your target audience. Regulatory Compliance: Align with evolving nutritional guidelines and regulations, positioning your products for long-term success. In conclusion, our flavor modulating compounds revolutionize the way food and beverages are formulated. By addressing the commercial need for healthier options without compromising on taste, our technology unlocks vast opportunities for manufacturers to create products that appeal to consumers' palates and prioritize their well-being. Join us on this journey towards a future of delightful, nutritious, and flavorful food and drink experiences.
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Peterson, Devin; Gao, Chengyu
  • Licensing Officer: Dahlman, Jason "Jay"

Scalable laser-assisted MOCVD chamber design with laser array input
TS-050244 — A design of scalable laser-assisted MOCVD chamber for III-nitrides and other semiconductors with a laser array input.
III-nitrides represent an important semiconductor material system for both optoelectronic and power electronic device applications. Advantages for III-nitrides include high electron saturation velocity, high critical electric field, high radiation resistance and decent thermal performance. Therefo…
  • College: College of Engineering (COE)
  • Inventors: Zhao, Hongping; Chen, Zhaoying
  • Licensing Officer: Randhawa, Davinder

An improved base editor (iABE-NG) for correcting genetic diseases such as Duchenne muscular dystrophy
TS-049505 — An engineered base editor (iABE-NG) that uses an SpCas9 variant, a shortened adenine deaminase domain with eliminated RNA off-target activity, and an intein split for packaging into an adeno-associated virus (AAV), resulting in gene mutation correction.
There are thousands of monogenic diseases that are lacking effective therapeutic treatments. The main bottleneck in developing effective treatment is the ability to effectively edit gene while controlling for the myriad of off-target effects that come with targeting the genome. Duchenne Muscular D…
  • College: College of Medicine (COM)
  • Inventors: Han, Renzhi; Gao, Yandi; Xu, Li
  • Licensing Officer: Schworer, Adam

Iron Oxide Composites with Low Concentration of Aliovalent Dopants As Oxygen Carrier Materials for Sustainable Redox Combustion and Gasification Reactions in Chemical Looping Reactor Systems
TS-038513 — Addition of low concentration aliovalent transition metal dopants substantially improves particle performance in chemical loopiong systems
Cyclic systems are required for energy conversion systems. In the clean energy industry, chemical looping offers promise for carbon dioxide capture from fossil energy. Transition metal oxides such as iron oxide, nickel oxide, and copper oxide have been singled out as the desired active oxygen carr…
  • College: College of Engineering (COE)
  • Inventors: Fan, Liang-Shih; Cheng, Zhuo; Chung, Cheng; Guo, Mengqing "MENGQING"; Qin, Lang
  • Licensing Officer: Ashouripashaki, Mandana

Novel Small-Molecule Integrin-linked Kinase/Phosphoinositide-dependent Protein Kinase-2 Inhibitors
TS-037647 — A novel set of molecules that inhibit integrin-linked kinase in order to suppress tumor cell growth and metastasis.
The Akt signaling pathway is responsible for apoptosis, cell proliferation, and metabolism. In tumor cells, this pathway is up-regulated and aids in promoting cancer cell survival. Complete activation of Akt pathway requires phosphorylation at two amino-acid residues, which are phosporylated by se…
  • College: College of Pharmacy
  • Inventors: Chen, Ching-Shih; Kulp, Samuel; Lee, Su-Lin
  • Licensing Officer: Taysavang, Panya

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