# of Displayed Technologies: 3 / 3


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Electrophiles for Re-activation of Aged Acetylcholine Esterase
TS-044619 — Organophosphorus (OP) poisons including sarin, VX, and novichoks are lethal agents of chemical warfare. Their toxicity is due to their direct inhibition of acetylcholinesterase (AChE), an enzyme that is vital to the nervous system via regulation of the neurotransmitter acetylcholine (ACh). AChE in…
  • College: College of Arts & Sciences
  • Inventors: Hadad, Christopher; Callam, Christopher; Corrigan, Thomas; Dicken, Rachel; Dogan Ekici, Ozlem; Fitzpatrick, Keegan; Franjesevic, Andrew; McElroy, Craig; McKenney, Ryan; Muthukrishnan, Siva; Sanan, Toby; Vyas, Shubham; Yoder, Ryan; Young, Amneh "Amneh"
  • Licensing Officer: Ezzell, Janel

Aza-peptide Aldehydes and Ketones: A New Class of Inhibitors for Proteases
TS-037264 — Novel aza-peptide reversible protease inhibitors, which permit more drug-like and selective activity than current irreversible aza-peptide containing inhibitors.
Proteases play an important role in cell processes such as apoptosis, immune response, protein turnover, digestion, blood coagulation and wound healing, fertilization, cell differentiation and growth, and cell signaling among other processes. Due to their large involvement in such processes, uncon…
  • College: College of Arts & Sciences
  • Inventors: Dogan Ekici, Ozlem; Corrigan, Thomas; Hadad, Christopher
  • Licensing Officer: Ezzell, Janel

Novel Spin Adduct for Free Radical Elimination
TS-015133 — 5-carbamoyl-5-methyl-1-pyrroline N-oxide (AMPO) as an improved cyclic spin trap, especially in mitigating superoxide radicals.
The linear PBN-type nitrones are limited by their ability to discern different radicals while the cyclic DMPO-type nitrones are limited by the stability of the adducts they form. Enolized DMPO-type spin adducts have been shown to dimerize and produce a six-line electron paramagnetic resonance (EPR…
  • College: College of Medicine (COM)
  • Inventors: Zweier, Jay; Hadad, Christopher; Villamena, Frederick
  • Licensing Officer: Davis, Stewart

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