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Revolutionizing Pharmaceutical Synthesis: Advancements in Metal-Catalyzed Coupling Technology
TS-064824 — The Need In the pharmaceutical industry, the synthesis of complex organic substrates is crucial for the development of life-saving medications. However, traditional metal-catalyzed coupling reactions often face significant challenges when applied to these complex substrates, leading to high failure…
  • College: College of Arts & Sciences
  • Inventors: Sevov, Christo; Dinh, Long; Hamby, Taylor; Starbuck, Hunter
  • Licensing Officer: Panic, Ana

Dual ligand systems for cross-coupling of challenging C(sp2) and C(sp3) electrophiles.
TS-059018 — An unusual series of ligand exchange reactions establishes a dualcatalyst system for electroreductive alkyl-aryl cross-electrophile couplings of previously incompatible substrate combinations.
Cross-electrophile coupling (XEC) reactions of aryl and alkyl electrophiles are desirable methodologies for C–C bond formation but are limited to specific substrate classes. Couplings of widely-available electrophiles such as aryl chlorides or triflates are currently unknown with any alkyl b…
  • College: College of Arts & Sciences
  • Inventors: Sevov, Christo; Hamby, Taylor
  • Licensing Officer: Panic, Ana

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