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3-Stage Membrane Processes for CO2 Capture from Flue Gases
TS-069650 — The Need The urgent need to mitigate climate change has driven the demand for efficient carbon capture technologies. Current methods often fall short in achieving high capture rates and purity levels, especially for industrial applications. This technology addresses the critical need for a scalable…
  • College: College of Engineering (COE)
  • Inventors: Han, Yang; Ho, W.S. Winston
  • Licensing Officer: Ashouripashaki, Mandana

Enhanced Butanol Production via Engineered Clostridium Strains
TS-069522 — The Need The biofuel and biochemical industries face challenges in efficiently converting fermentation byproducts, such as butyrate, into higher-value products like butanol. Traditional methods often result in the accumulation of waste products, limiting overall process efficiency and economic viab…
  • College: College of Engineering (COE)
  • Inventors: Moore, Curtis; Yang, Shang-Tian "ST"
  • Licensing Officer: Randhawa, Davinder

Novel Efficient Butanol Production without CO2 Emission
TS-068795 — The Need Renewable energy resources have gained global interest due to environmental issues, climate change, oil price and supply volatility, and decreasing nonrenewable fossil fuel sources. Butanol is a biofuel alternative that can provide a higher heating value, lower volatility, polarity, cor…
  • College: College of Engineering (COE)
  • Inventors: Yang, Shang-Tian "ST"
  • Licensing Officer: Randhawa, Davinder

Small Molecule USP30 Inhibitors for the Treatment and Prevention of Cardiomyopathy
TS-066773 — The Need Cardiomyopathy, a disease of the heart muscle, poses significant public health challenges due to its diverse causes, symptoms, and potential complications, including heart failure and arrhythmias. With cardiomyopathy often induced by drugs, such as anthracyclines used in chemotherapy, ther…
  • College: College of Medicine (COM)
  • Inventors: Sun, Nuo; Krigman, Judith; Yang, Mingchong; Zhang, Ruohan
  • Licensing Officer: Willson, Christopher

Thermotropic liquid crystal-based sensors for naked-eye detection of SARS-CoV-2 with ultrahigh sensitivity and selectivity
TS-063069 — In the wake of the global pandemic caused by SARS-CoV-2, the need for rapid, accurate, and efficient diagnostic methods for respiratory viral infections has become more critical than ever. Traditional diagnostic methods, while reliable, are often time-consuming, labor-intensive, and lack the neces…
  • College: College of Engineering (COE)
  • Inventors: Wang, Xiaoguang; Qin, Rongjun; Rather, Adil; Xu, Yang
  • Licensing Officer: Randhawa, Davinder

Propionibacterium acidipropionici Knockout Mutant for Propionic Acid Fermentation
TS-062323 — The Need: In today's industrial landscape, the demand for sustainable and cost-effective bio-based chemicals continues to rise. Propionic acid, a valuable building block in various industries, including food, pharmaceuticals, and plastics, is no exception. However, conventional production method…
  • College: College of Engineering (COE)
  • Inventors: Yang, Shang-Tian "ST"
  • Licensing Officer: Panic, Ana

Probiotic strains for reducing antibiotic resistance and modulating gut health
TS-037818 — A novel advancement to mitigate antibiotic resistance in the ecosystem.
The Need In today's world, the rapid emergence of antibiotic resistance (AR) poses a serious threat to public health, making it crucial to explore alternative strategies to combat this issue. Traditional approaches targeting pathogenic bacteria alone have proven insufficient due to the complexi…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Wang, Hua; Wang, Zihua; Zhang, Lu; Zhou, Yang
  • Licensing Officer: Dahlman, Jason "Jay"

Production of Galacto-oligosaccharides from Lactose by Enzyme Immobilized on Cotton Cloth
TS-037689 — Lactose from cheese whey is converted from a dairy byproduct to a useful prebiotic using enzymes immobilized on cotton cloth.
Galacto-oligosaccharides (GOS) are a collection of prebiotic fibers made of a chain of galactose sugars of variable length. GOS has been shown to exert some of the most potent and beneficial effects among prebiotic fibers. When added to infant formula, it can change bowel flora to approximate the …
  • College: College of Engineering (COE)
  • Inventors: Yang, Shang-Tian "ST"; Albayrak, Nedim
  • Licensing Officer: Panic, Ana

Methods for Making Three Dimensional Microfluidic Bioreactor Array
TS-037642 — Design for a three-dimensional microfluidic bioreactor array; device allows for culturing of a variety of cell types without contamination.
Cell culture in a three-dimensional fluidic-flow microenvironment is critical for long-term cell-based assays. Conducting in vitro research offers an accessible, reproducible, and reliable mode of investigation for therapeutic decisions before work is conducted in vivo. However, because of the com…
  • College: College of Engineering (COE)
  • Inventors: Yang, Shang-Tian "ST"; Wen, Yuan
  • Licensing Officer: Panic, Ana

Functionalization of Polymethylmethacrylate (PMMA) Surface by Amination with Polyethyleneimine (PEI) for Applications in Microfluidic Immunoassays, Protein/Enzyme Biochips, and Biocatalysis
TS-037631 — Polymethylmethacrylate (PMMA) is a useful material for development of assays, biochips, and other biological materials. However, PMMA makes for a difficult substrate because of complexities with respect to adhesion. This technology presents two new methods for enhanced protein binding onto PMMA.
Polymethylmethacrylate (PMMA) is a synthetic resin in the acrylic family, often used as a substitute for glass or as a material for biomedical devices. PMMA-based biosensors have low protein binding efficiency and low sensitivity. PMMA is used in a variety of applications like immunoassays, biosen…
  • College: College of Engineering (COE)
  • Inventors: Yang, Shang-Tian "ST"; Bai, Yunling
  • Licensing Officer: Panic, Ana

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