Available Technologies
# of Displayed Technologies: 10 / 62
Small Molecule USP30 Inhibitors for the Treatment and Prevention of Cardiomyopathy
TS-066773 — The Need
Cardiomyopathy, a disease of the heart muscle, poses significant public health challenges due to its diverse causes, symptoms, and potential complications, including heart failure and arrhythmias. With cardiomyopathy often induced by drugs, such as anthracyclines used in chemotherapy, ther…
- College: College of Medicine (COM)
- Inventors: Sun, Nuo; Krigman, Judith; Yang, Mingchong; Zhang, Ruohan
- Licensing Officer: Willson, Christopher
Biofilm Detachment Monitoring for Enhanced Oral Health Solutions
TS-066772 — The Need
Biofilms, particularly dental plaque-biofilms, are communities of microorganisms encased in a slimy extracellular polymeric substance (EPS) that adhere to surfaces or neighboring microorganisms. These biofilms are responsible for various infectious diseases, including oral diseases such as…
- College: College of Medicine (COM)
- Inventors: Stoodley, Paul; Gloag, Erin
- Licensing Officer: Willson, Christopher
Innovative Biomarker Technology for Detecting and Treating Endothelial Injury in Neurological Disorders
TS-066771 —
Endothelial injury is a significant pathological mechanism underlying various neurological disorders, including neurodegenerative, neuroinflammatory, and cerebrovascular diseases. Current clinical and research settings lack reliable biomarkers to detect or measure endothelial injury in the human C…
- College: College of Medicine (COM)
- Inventors: Al Tarawneh, Rawan
- Licensing Officer: Willson, Christopher
Innovative Small Molecule Inhibitors for Effective Treatment and Prevention of Coronavirus Infections
TS-066750 —
The ongoing COVID-19 pandemic, caused by the SARS-CoV-2 virus, has significantly impacted global health and economies. Despite vaccine efforts, issues such as vaccine hesitancy, delays in distribution, and emerging variants have highlighted the need for effective therapeutic interventions. These i…
- College: College of Veterinary Medicine
- Inventors: Sharma, Amit; Li, Pui-Kai "Tom"; Xing, Enming
- Licensing Officer: Willson, Christopher
Innovative Solutions for Cell Viability and Targeted Delivery
TS-066100 — Research tool to transfect cells ex vivo using electroporation through electrospun core-shell fibers for research applications
The Need:
Conventional electroporation methods often result in low cell viability due to heat generation, especially when working with primary cells. These methods also face challenges with non-specific transport of molecules, high vector integration rates leading to mutagenesis, and inefficacy in …
- College: College of Engineering (COE)
- Inventors: Gallego Perez, Daniel; Das, Devleena; Duarte Sanmiguel, Silvia; Higuita Castro, Natalia
- Licensing Officer: Willson, Christopher
T-cells with Enhanced Ability to Respond to Exogenous Ligands
TS-066052 — Novel T-cells expressing the IL-2a receptor to enhance cancer cell targeting.
The Need
As interest in cell-based therapies, particularly for cancer treatment, continues to rise, there’s a critical need for therapeutic cells capable of robust proliferation in vivo. Existing methods relying on exogenous cytokines like IL-2 face challenges due to dose-limiting toxicity an…
- College: OSU Wexner Medical Center
- Inventors: Rubinstein, Mark
- Licensing Officer: Willson, Christopher
Novel Antibodies Targeting IL-2
TS-066051 — Novel antibodies targeting IL-2 with the ability to inhibit IL-2 signaling through IL-2 Rαβg to a greater extent than through IL-2 Rβg.
IL-2 and its receptor IL-2R are known to play multiple roles in shaping the immune response, including both immune activation and tolerance. Expression of intermediate-affinity IL-2 receptors by different immune cell subsets determines cellular sensitivity to IL-2. However, the dynamic interplay bet…
- College: OSU Wexner Medical Center
- Inventors:
- Licensing Officer: Willson, Christopher
Gene Therapy Approach for Treating Neuropathy
TS-065913 — Gene therapy strategies for treating peripheral neuropathy.
Peripheral neuropathy (PN) results in loss of innervation by the peripheral nerves in tissues such as skin, muscle, heart, and adipose tissue. It is a painful, debilitating disease, that is estimated to affect between 20 and 30 million Americans. The number of Americans affected by PN is likely muc…
- College: College of Medicine (COM)
- Inventors: Townsend, Kristy; Blaszkiewicz, Magdalena; Cao, Lei
- Licensing Officer: Willson, Christopher
Protease-free Bacillus subtilis host
TS-065845 — The Need: In the realm of biotechnology, the challenge of synthesizing enzymes, pharmaceuticals, and fine chemicals efficiently is paramount. However, the presence of multiple proteases secreted by Bacillus subtilis 168 during growth stages poses a significant obstacle to achieving optimal productio…
- College: College of Arts & Sciences
- Inventors: Zeigler, Daniel
- Licensing Officer: Willson, Christopher
Targeting Telomerase to Treat Ocular Neovascular Disorders
TS-065809 — Therapeutic strategies for treating ocular neovascular disorders by targeting telomerase.
Choroidal neovascularization (CNV) is the principal driver of blindness in neovascular age-related macular degeneration (nvAMD). Abnormal blood vessel growth beneath the macular leads to retinal damage and severe vision loss. Discovering the involvement of VEGF in the underlying mechanisms driving …
- College: College of Medicine (COM)
- Inventors: Kerur, Nagaraj
- Licensing Officer: Willson, Christopher
