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TS-065846 — The Need: With the persistent threat of avian diseases, ensuring the health and safety of turkey populations is of utmost importance to the poultry industry. Traditional methods of disease prevention have limitations, necessitating a technology that can reliably produce Specific Pathogen Free (SPF) …

College: College of Food, Agricultural, and Environmental Sciences (CFAES)
Inventors: Saif, Mo
Licensing Officer: Panic, Ana

Avian Genome Editing Advancements- Improving production efficiency

TS-062249 — The Need: Unlocking Avian Genetic Potential The poultry industry plays a crucial role in meeting the growing demand for protein-rich food worldwide. However, avian genetic research has been limited by the complexity of editing avian genomes efficiently. Conventional methods utilizing primordial ger…

College: College of Food, Agricultural, and Environmental Sciences (CFAES)
Inventors: Lee, Kichoon "Kichoon"; Lee, Joonbum
Licensing Officer: Dahlman, Jason "Jay"

DAT-CI knock-in mouse model carrying a modified dopamine transporter that maintains the transport function but resistant to cocaine inhibition and thus showing no rewarding cocaine effects

TS-058669 — A knock-in mouse model carrying a modified dopamine transporter that is resistant to cocaine inhibition and thus showing no rewarding cocaine effects.

Cocaine abuse has been an issue in the United States since the late 1980s. The highly addictive qualities along with the low cost ruined people’s lives and destroyed communities. Naloxone (marketed as Narcan) is highly effective but can only be used in the event of an overdose. Therefore, th…

College: College of Medicine (COM)
Inventors: Gu, Howard
Licensing Officer: Schultz, Teri

NET-CI knock-in mouse model with a modified norepinephrine transporter carrying triple mutations that maintains the transport function and makes the transporter protein resistant to cocaine and antidepressants

TS-058668 — A knock-in mouse model with a modified norepinephrine transporter carrying triple mutations that makes the transporter protein resistant to cocaine and antidepressants.

Cocaine abuse has been an issue in the United States since the late 1980s. Furthermore, antidepressants also quite dangerous, with nearly 14% of users (who have bipolar disorder) experiencing dependence. Naloxone (marketed as Narcan) is highly effective but can only be used in the event of an over…

College: College of Medicine (COM)
Inventors: Gu, Howard
Licensing Officer: Schultz, Teri

Rabbit Model for Duchenne Muscular Dystrophy

TS-058084 — A rabbit model has been created for Duchenne Muscular Dystrophy (DMD) that more closely resembles the effects experienced in humans while being more cost effective compared to larger animal models.

There has yet to be a DMD animal model that bridges the gap between cost effectiveness and scientific relevance. This new rabbit model does that. DMD is a lethal genetic disease characterized by progressive muscle weakness and muscle wasting. There are several animal models for DMD, includin…

College: College of Medicine (COM)
Inventors: Han, Renzhi
Licensing Officer: Schworer, Adam

A novel mouse model of spontaneous chronic lymphocytic leukemia

TS-055268 — The laboratory of Dr. Rosa Lapalombella in collaboration with Dr. James Blachly at The Ohio State University has developed a mouse model of spontaneous Chronic Lymphocytic Leukemia.

The Need Chronic lymphocytic leukemia (CLL) accounts for one quarter of new cases of leukemia. CLL is the most prevalent adult leukemia in Western countries and is characterized by a mature B-cell phenotype. Given the burden of this disease, a large pipeline of drugs for treatment are in progress…

College: College of Medicine (COM)
Inventors: Lapalombella, Rosa; Blachly, James; Byrd, John
Licensing Officer: Schworer, Adam