The Need: Unlocking Avian Genetic Potential

The poultry industry plays a crucial role in meeting the growing demand for protein-rich food worldwide. However, avian genetic research has been limited by the complexity of editing avian genomes efficiently. Conventional methods utilizing primordial germ cells (PGCs) involve intricate in vitro steps and struggle to maintain germline competence, hindering progress in avian genome editing. A novel, efficient, and easily applicable avian genome editing method is urgently required to unlock the genetic potential of various avian species.

The Technology: Adenovirus-Mediated Avian Genome Editing

Introducing a groundbreaking avian genome editing method, our technology targets primordial germ cells (PGCs) directly within avian embryos using an adenovirus containing the CRISPR/Cas9 system. By focusing on the blastodermal stage in freshly laid eggs, the central region of the quail blastoderm is injected with the adenovirus, effectively targeting PGCs. This approach enables the production of potential germline mutant founders and genome-edited offspring, streamlining the process and overcoming the limitations of previous techniques.

Commercial Applications: A Versatile Solution

Our cutting-edge avian genome editing technology holds vast potential in numerous commercial applications:

• Improved Poultry Production: Unlocking the genetic potential of avian species allows for enhanced growth rates and better feed efficiency, benefiting the poultry industry economically.

• Customized Livestock Traits: Targeted gene modifications enable the development of desired traits, such as increased muscle mass, providing lucrative opportunities in the livestock industry.

• Research Advancement: Our technology opens new avenues in avian research, allowing scientists to investigate various genetic functions and contribute to the advancement of scientific knowledge.

Benefits/Advantages: Enhancing Poultry Farming and Research

• Efficiency and Convenience: By targeting blastodermal PGCs directly, the adenovirus-mediated method eliminates the need for complex and technically demanding in vitro PGC culture steps, significantly simplifying the genome editing process.

• Increased Productivity: The introduction of targeted gene mutations can lead to improved feed efficiency, higher muscle mass, and enhanced growth rates, directly impacting the profitability of poultry farming.

• Scientific Insights: Through functional genomic studies enabled by our technology, researchers gain valuable insights into avian genetics, providing a scientific basis for selecting genetic markers to improve specific traits in poultry species.

• Versatility and Applicability: The technology can be applied to various avian species, making it a versatile tool for researchers and industries alike.

• Ethical Considerations: Our technology offers a more targeted and precise approach to genome editing, reducing the need for extensive in vitro manipulations, and aligning with ethical standards.

Embrace the future of avian research and poultry farming with our revolutionary genome editing technology. Empower your projects with efficiency, precision, and profound scientific insights to unlock the full potential of avian genetics.