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Innovative Biomarker Technology for Detecting and Treating Endothelial Injury in Neurological Disorders
TS-066771 — Endothelial injury is a significant pathological mechanism underlying various neurological disorders, including neurodegenerative, neuroinflammatory, and cerebrovascular diseases. Current clinical and research settings lack reliable biomarkers to detect or measure endothelial injury in the human C…
  • College: College of Medicine (COM)
  • Inventors: Al Tarawneh, Rawan
  • Licensing Officer: Willson, Christopher

Precision RNA-PROTACs: Revolutionizing Therapeutic Targeting of Dysregulated Ribonucleoprotein Complexes
TS-065457 — The Need: In the realm of therapeutic development, there's a pressing need for precise targeting of dysregulated ribonucleoprotein (RNP) complexes to combat various diseases, particularly neurodegenerative disorders like ALS, Alzheimer’s, and Huntington’s diseases. Traditional metho…
  • College: College of Arts & Sciences
  • Inventors: Bong, Dennis; Liang, Yufeng; Miao, Shiqin "Shiqin"; Strong, Rebekah
  • Licensing Officer: Panic, Ana

A Breakthrough in Central Nervous System Repair
TS-062739 — Method to program pericytes for axon regeneration and spinal cord injury repair.
In the realm of central nervous system (CNS) repair, a critical need arises for innovative treatments that not only address the physical aspects of injury but also tackle the associated phychopathology. Understanding the cellular processes that occur after spinal cord injury (SCI) that are detrimen…
  • College: College of Medicine (COM)
  • Inventors: Tedeschi, Andrea
  • Licensing Officer: Willson, Christopher

Revolutionizing Vascular Access Management for Hemodialysis Patients
TS-062693 — Dynamic AVF flow control: A paradigm shift in vascular access management for hemodialysis patients.
Patients with end-stage renal disease (ESRD) undergoing hemodialysis (HD) face critical challenges in maintaining functional vascular access. Despite the superiority of arteriovenous fistulas (AVFs) in terms of longevity, infection rates, and cost-effectiveness, over a third of AVFs fail to mature a…
  • College: College of Medicine (COM)
  • Inventors: Boobes, Khaled
  • Licensing Officer: Schultz, Teri

Immune Based Neuroprotective & Neuroregenerative Therapies
TS-062688 — Conditioned neutrophils and cell therapy vectors for nerve regeneration
The Need Neurological disorders arising from central nervous system (CNS) injuries and diseases pose significant challenges to quality of life. The limited capacity of CNS neurons to regenerate and the lack of effective therapies for conditions like glaucoma, optic nerve injury, and spinal cord inj…
  • College: College of Medicine (COM)
  • Inventors: Segal, Benjamin; Jerome, Andrew; Liu, Tom; Sas, Andrew
  • Licensing Officer: Bhatti, Hamid

Nanobody-based Protein Degraders for the Treatment of Neurodegenerative Diseases
TS-062678 — Neurodegenerative diseases including Alzheimer's and Parkinson’s diseases, amyotrophic lateral sclerosis (ALS), prion diseases, and among others affect millions of people in the US. These diseases are relentless, often fatal, and affect fundamental functions – things like moving, bre…
  • College: College of Medicine (COM)
  • Inventors: Chu, Nam; Le, Nhat
  • Licensing Officer: Willson, Christopher

Methods and Apparatus to Improve MRI Efficiency
TS-062627 — Magnetic Resonance Imaging (“MRI”) is one of the most important modern medical imaging modalities. It has far less risk of side effects than most other imaging modalities. Generally, a high quality image requires high signal-to-noise ratio, high contrast between normal and pathological t…
  • College: College of Arts & Sciences
  • Inventors: Wang, Jinghua
  • Licensing Officer: Panic, Ana

Drug Delivery System for the Treatment of Neurological Diseases
TS-054464 — Novel drug delivery system that enables efficient transfer of FDA-approved drugs for the treatment of neurological injuries.
Traumatic brain and spinal cord injury cause devastating neurological deficits and long-term disability due to detrimental structural and functional alteration in neuronal circuits. Treatment of brain injury and neurological disorders has traditionally been challenging due to the inability to deli…
  • College: College of Engineering (COE)
  • Inventors: Lannutti, John; Fan, Fan; Tedeschi, Andrea
  • Licensing Officer: Willson, Christopher

Protecting Against Chemical Threats: A Revolutionary Solution
TS-044619 — The Need: The threat of chemical weapons, such as sarin gas and VX, looms large in today's world. These organophosphorus (OP) nerve agents can cause rapid and devastating neurological damage, leading to paralysis, respiratory failure, and death. Current treatments, like oximes, are ineffective …
  • College: College of Arts & Sciences
  • Inventors: Hadad, Christopher; Callam, Christopher; Corrigan, Thomas; Dicken, Rachel; Dogan Ekici, Ozlem; Fitzpatrick, Keegan; Franjesevic, Andrew; McElroy, Craig; McKenney, Ryan; Muthukrishnan, Siva; Sanan, Toby; Vyas, Shubham; Yoder, Ryan; Young, Amneh "Amneh"
  • Licensing Officer: Panic, Ana

Translational Activators of the Glutamate Transporter EAAT2 to Treat Neurological and Psychiatric Diseases
TS-043938 — Small molecule technology with novel translational activation mechanism.
Glutamate is a major neurotransmitter in the mammalian central nervous system (CNS) and essential for normal brain function including cognition, memory, and learning. However, the extracellular concentration of glutamate must remain below excitotoxic levels (~ 1 μM) to avoid overstimulation of …
  • College: College of Medicine (COM)
  • Inventors: Lin, Chien-Liang
  • Licensing Officer: Schworer, Adam

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