Correcting Signal Inhomogeneity in Magnetic Resonance Imaging (MRI)

The Need: Signal intensity inhomogeneity in Magnetic Resonance (MR) imaging presents a significant challenge, leading to degradation in image quality, obstructed diagnoses, reduced accuracy in quantitative analyses, and increased inter-scanner variability. The lack of effective inhomogeneity correction methods hinders the advancement of MR imaging and spectroscopy techniques, requiring extensive manual effort and producing conflicting results in performance evaluations.

The Technology: The disclosed technology offers a novel in vivo method for correcting MR signal inhomogeneity caused by non-tissue characteristics. It quantifies and corrects inhomogeneities caused by both transmit field and receiver sensitivity separately, significantly improving the accuracy and precision of MR imaging and spectroscopy techniques. The method involves producing a set of signal intensity images, estimating relative flip angle maps and transmit field maps, calculating a relative correction image, and applying correction matrixes or images to normalize and correct the inhomogeneous signal intensity.

Commercial Applications:

  1. Medical Imaging: The technology can be applied in clinical settings to enhance the quality and accuracy of MR images, enabling better diagnoses and treatment planning for various medical conditions.
  2. Neuroscience Research: In research settings, the technology facilitates more precise and consistent MR imaging and spectroscopy, supporting studies on brain function, structure, and neurodegenerative diseases like Alzheimer's.
  3. Drug Development: Pharmaceutical companies can use the technology to improve the accuracy of MR data in preclinical and clinical trials, leading to better insights into drug efficacy and safety profiles.


  1. Improved Image Quality: By effectively correcting signal intensity inhomogeneities, the technology enhances MR image quality, allowing for clearer visualization of anatomical structures and pathophysiological changes.
  2. Enhanced Quantitative Analysis: The corrected MR data leads to more accurate and reliable quantitative analyses, providing researchers and clinicians with robust measurements for their studies and diagnoses.
  3. Inter-scanner Consistency: The technology reduces inter-scanner variability, ensuring MR images acquired on different scanners and at different time points yield consistent and comparable results.
  4. Simplified Performance Evaluation: Utilizing in vivo phantom experiments for performance evaluation offers more reliable results compared to simulation-based methods, aiding end-users in selecting the most suitable correction method for specific applications.
  5. Versatility across Imaging Modalities: The technology's correction methods are applicable to various imaging modalities like CT, X-ray, ultrasound, and transmission electron microscopy, broadening its potential for diverse research and clinical applications.

In summary, the disclosed MR signal inhomogeneity correction technology meets a critical need in the field of MR imaging and offers substantial benefits to the medical, neuroscience, and pharmaceutical industries. Its novel approach in separating transmit field and receiver sensitivity corrections, along with in vivo validation, sets it apart as an effective and versatile solution for enhancing MR image quality and accuracy.


Patent # Title Country
10247802 Signal Inhomogeneity Correction and Performance Evaluation Apparatus United States of America
10247802 Signal Inhomogeneity Correction and Performance Evaluation Apparatus United States of America

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