Modulation of Mismatch Repair and Genomic Stability by miR-155

The Need

The field of molecular biology faces a critical commercial need in the effective diagnosis, treatment, and prevention of cancer-related disorders associated with mismatch repair (MMR) dysfunction. Diseases such as Lynch Syndrome (LS) and hereditary non-polyposis colorectal cancer (HNPCC), along with a significant proportion of sporadic colorectal, endometrial, ovarian, gastric, and urothelial cancers, are linked to MMR defects. Current methods for diagnosing and treating these conditions are limited, resulting in suboptimal patient outcomes and increased mortality rates. There is an urgent demand for innovative cancer-related technology that can address these challenges and significantly improve patient care.

The Technology

The presented technology is a groundbreaking approach in the realm of cancer-related molecular biology. It revolves around the modulation of MicroRNAs (miRs), which are non-coding RNAs controlling crucial cellular pathways involved in development and cancer. Specifically, the technology focuses on miR-155, which has been observed to be overexpressed in colorectal cancer (CRC), especially in cases with microsatellite instability (MSI). The technology has successfully demonstrated that miR-155 significantly down-regulates core MMR proteins (hMSH2, hMSH6, and hMLH1), leading to a mutator phenotype and MSI. This discovery opens new possibilities for targeted diagnostics and therapeutics of MMR-associated disorders.

Commercial Applications

The technology's versatility and potential for various applications are evident, particularly in the following commercial areas:

  • Diagnostic Tools: The technology offers methods to identify MMR dysfunctional cells in test samples, enabling early and accurate diagnosis of conditions such as Lynch Syndrome, hereditary non-polyposis colorectal cancer, and other MMR-related diseases.
  • Prognostic Indicators: The technology provides methods to assess the prognosis of patients based on miR-155 expression levels. This aids in predicting clinical outcomes, enabling personalized treatment plans for better patient management.
  • Therapeutic Solutions: The technology opens avenues for treating MMR dysfunction in patients, with the potential to target colorectal, endometrial, ovarian, gastric, and urothelial cancers using anti-sense miRNA-155 and complementary compounds, including chemotherapy drugs and targeted therapies.


The technology presents several key advantages that address critical unmet needs in the field of molecular biology and cancer-related research:

  • Enhanced Diagnostics: By accurately identifying MMR dysfunctional cells and assessing miR-155 expression levels, the technology allows for earlier and more precise disease diagnosis, leading to improved patient outcomes and survival rates.
  • Personalized Medicine: The ability to predict clinical outcomes and identify therapeutic agents based on miR-155 expression offers personalized treatment approaches, optimizing treatment efficacy and reducing potential adverse effects.
  • Novel Therapeutic Targets: The technology's modulation of miR-155 and core MMR proteins provides a unique and promising avenue for developing targeted therapies, expanding the scope of cancer treatment options.
  • Improved Research Tools: The inclusion of kits for identifying differentially-expressed miR-155 in MMR dysfunction disease allows researchers to conduct in-depth studies and advance the understanding of cancer pathogenesis, ultimately leading to further advancements in cancer treatment and prevention.

In conclusion, this innovative cancer-related technology represents a game-changer in molecular biology, addressing critical commercial needs in cancer diagnosis, treatment, and research. With its potential to significantly impact patient care and improve outcomes, this technology is poised to revolutionize the field and pave the way for a new era of precision medicine in cancer-related disorders.


Patent # Title Country
9023825 Materials and Methods Related to Modulation of Mixmatch Repair and Genomic Stability by miR-155 United States of America

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