Cell-Penetrating Peptides: Revolutionizing Intracellular DeliveryThe NeedIn the rapidly evolving field of biotechnology and pharmaceuticals, there is a critical need for efficient delivery mechanisms to transport therapeutic agents directly into cells. Traditional methods face challenges with membrane impermeability and degradation of therapeutic compounds, limiting their efficacy. This gap necessitates innovative solutions to enhance intracellular delivery, particularly for peptides, proteins, nucleic acids, and nanoparticles, which hold potential for novel and more effective treatments. The TechnologyCell-penetrating peptides (CPPs) are short sequences of amino acids (typically 5-30) that can traverse the eukaryotic cell membrane without causing significant damage. This technology leverages the unique properties of CPPs to deliver otherwise membrane-impermeable cargoes into mammalian cells efficiently. Recent advancements have introduced cyclic CPPs, which exhibit higher resistance to proteolytic degradation and improved cytosolic entry efficiencies compared to their linear counterparts. These enhancements are achieved by increasing membrane-binding affinity and optimizing the peptides' structural rigidity. Commercial Applications
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Tech IDT2024-143 CollegeLicensing ManagerDahlman, Jason "Jay" InventorsCategories |