Direct Analysis of Air and Water Sensitive Material by In-Chamber Ionization Mass Spectrometry

The Need

Due to the unparalleled ability of Mass spectrometry (MS) to identify and quantify substances at the molecular level it is an indispensable tool in various industries, from pharmaceuticals and forensics to environmental monitoring and materials science. However, the power of MS is often hindered by complex sample preparation processes. These processes can be time-consuming, leading to sample loss and degradation, and introduce contaminants that interfere with analysis. Additionally, the cost and environmental impact of the solvents used in sample preparation can be significant.

The Technology

Our air-tight ambient mass spectrometry platform is a groundbreaking technology that operates within a sealed chamber, offering complete protection against air and moisture contamination. Ions generated in the chamber are transported by a carrier gas to the spectrometer, removing the need for a solvent, allowing for easier and improved read outs of the materials composition and chemical makeup.

Commercial Applications

  • Energy Sector: Development of battery, fuel cell and renewable energy technologies. Battery development in particular, such as Li-ion, stands to benefit from in-depth analysis of SEI layers, leading to advancements in battery performance, longevity and safety.
  • Semiconductor Industry: This technology would aid in R&D efforts like material analysis and process optimization, as well as quality control.
  • Pharmaceutical Industry: Analysis of compounds for drug discovery, screening, impurity profiling and quality control.
  • Environmental Monitoring: Detection of air and soil pollutants, and forensics toxicology.
  • Food Safety: Analyzing for contaminants or adulterants.

Benefits/Advantages

  • Non-destructive Analysis: due to the direct analysis of samples, this method is non-destructive allowing for repeated analysis for dynamic changes and/or further characterization. It also reduces sample loss.
  • Solvent Free Conditions: reduces matrix effects and risk of sample contamination, producing higher quality data and streamlining analysis.
  • Versatility: Approach can be applied to inorganic to organic compounds and air or water-sensitive materials.
  • Cost Effective: Less time spent on sample preparation and fewer reagents means this MS technology produces faster results and a more cost-effective approach.

Patents

  • Patent Pending PCT/US2023/022045

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