Technology Overview

Mosquito‑borne diseases such as dengue, Zika, chikungunya, and yellow fever remain major global health threats, however widespread resistance has eroded the effectiveness of existing insecticides. mosquito control agents for public health, vector control programs, and integrated pest management strategies

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The Technology

Derived from a natural product with known mosquitocidal and antifeedant properties researchers at the Ohio State University have developed insecticidal compounds. These small‑molecule insecticidal compounds were optimized via semi‑synthetic medicinal chemistry identifying the new drimane and quinone chemotypes with improved stability and enhanced activity against Aedes aegypti.

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Benefits

The primary target is the mosquito Aedes aegypti, a key vector responsible for transmitting multiple arboviral diseases. The compounds also

• Addresses resistance pressures by engaging mosquito biology through mechanisms distinct from commonly used insecticide classes and acts at the organismal level.
• Effective against adult and larval forms.
• Adaptable to multiple delivery platforms (e.g. spray, cream, etc.)
• Enhanced stability and activity

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Ohio State University is seeking business leads interested in licensing or collaborative early‑stage research opportunities in vector control and insecticide development.