Problem

Glioblastoma multiforme (GBM) is the most malignant form of gliomas and the most lethal primary brain tumors in adults. Current biomarkers or clinical features from tissue biopsy samples cannot distinguish glioma true progression from pseudoprogression and might not be suited to monitoring the tumor activity during the treatment. Lack of effective early diagnosis results in lost lifesaving opportunities through early treatment.

Solution

• Use specific EV RNA signature as biomarkers for definitive diagnosis, grading and characterization of brain cancers including glioblastomas
• Developed a non-invasive biochip assay to detect single EV (siEV) mRNA and miRNA expressions
• AUC of ROC reached 1 when combining single EV (siEV) mRNA and miRNA expression signatures

Applications

• Use single extracellular vesicular RNA signature as diagnostic biomarkers for brain cancers including glioblastoma

Advantages

• High specificity and accuracy for GBM diagnosis with AUC reaching 1
• Non-invasive biochip assay for blood-based GBM diagnosis
• >100-fold higher sensitivity over standard PCR

Seeking opportunities for licensing, collaboration or new venture formation