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Revolutionizing Pharmaceutical Synthesis: Advancements in Metal-Catalyzed Coupling Technology
TS-064824 — The Need In the pharmaceutical industry, the synthesis of complex organic substrates is crucial for the development of life-saving medications. However, traditional metal-catalyzed coupling reactions often face significant challenges when applied to these complex substrates, leading to high failure…
  • College: College of Arts & Sciences
  • Inventors: Sevov, Christo; Dinh, Long; Hamby, Taylor; Starbuck, Hunter
  • Licensing Officer: Willson, Christopher

Post synthetic incorporation of Ti into zeolite Beta via defect sites originating from methyl-silanes and its impacts on epoxidation and reduction reactions
TS-062968 — A novel method of creating catalytic material containing paired Lewis acids in combination with alkyl-metal precursors for improving the production of materials used in agricultural, chemical, and other commercial/industrial applications/processes.
More efficient techniques to create catalytic material are required to enable higher efficiencies and other performance improvements when used for manufacturing of specialty chemicals and other compounds. The conventional methods whereby Lewis acids play a role in catalysis has some key limitation…
  • College: College of Engineering (COE)
  • Inventors: Brunelli, Nicholas "Nick"; Spanos, Alex
  • Licensing Officer: Randhawa, Davinder

Tuning the nature of the catalytic site through synthesizing Lewis acid zeolite Beta with alkyl-Sn precursors
TS-062967 — Novel method capable of using alkyl tin compounds to generate Lewis acid zeolite Sn-Beta.
Conventional approaches used in chemical processes such as synthesis for production of materials involve formation of catalytic sites within the process framework. Current methods used for catalytic site creation tend to be long and result in increased production costs. This is partially due to re…
  • College: College of Engineering (COE)
  • Inventors: Brunelli, Nicholas "Nick"; Spanos, Alexander
  • Licensing Officer: Randhawa, Davinder

Fluorescent probes for intracellular RNA tracking
TS-062554 — The Need: Intracellular RNA fluorescence labeling is a crucial technique for studying cellular processes and understanding gene expression. However, the conventional MS2 labeling method using protein fusion labels can have drawbacks, such as increased mass, potential steric accessibility issues, and…
  • College: College of Arts & Sciences
  • Inventors: Bong, Dennis; Liang, Yufeng
  • Licensing Officer: Willson, Christopher

CPSMV-based Gene Expression System-Enhancing the understanding of gene functions in crops
TS-062263 — The Need In the agricultural industry, soybean research has faced significant challenges in effectively interrogating gene functions due to the complex and time-consuming process of soybean transformation. The conventional methods of gene disruption and overexpression are hindered by technical diff…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Qu, Feng
  • Licensing Officer: Dahlman, Jason "Jay"

Quadruplex-based non-enzymatic DNA signal amplification
TS-042905 — A quadruplex-based non-enzymatic DNA signal amplification scheme for point of care diagnostic testing.
Currently, non-enzymatic signal amplification assays, an alternative to PCR, are complicated reactions employing multiple DNA constructs. The most successful non-enzymatic assays rely on stand-displacement reactions within DNA duplexes that result in background activity. Because of this background…
  • College: College of Arts & Sciences
  • Inventors: Kankia, Besik
  • Licensing Officer: Willson, Christopher

Novel small peptide polarizing agents for dynamic nuclear polarization (DNP) nuclear magnetic resonance (NMR) spectroscopy
TS-038322 — Versatile small biradical peptide molecules that can serve as biradical polarizing agents for dynamic nuclear polarization (DNP) solid-state nuclear magnetic resonance spectroscopy.
DNP methodology offers dramatic sensitivity enhancements of NMR experiments (up to 1-2 orders of magnitude) by transferring the large electron spin polarization to the nuclei of interest, and is currently one of the research frontiers in the magnetic resonance field with numerous applications to b…
  • College: College of Arts & Sciences
  • Inventors: Jaroniec, Christopher; Conroy, Daniel
  • Licensing Officer: Willson, Christopher

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