TS-053103 — Uncontrolled hemolysis (i.e., destruction of red blood cells) is characterized by the increase of circulating toxic cell-free hemoglo
bin, heme and iron in the bloodstream. In vivo, the body’s natural supply of plasma scavenger proteins acts to neutra
lize these toxic species. However, these scavenger proteins such as haptoglo
bin, hemopexin and transferrin, which detoxify hemoglo
bin, heme and iron, respectively, are depleted in various c
linical conditions such as hemorrhagic shock, burns, surgery, organ transplantation, sepsis and trauma.
Dr. Andre Palmer’s lab at The Ohio State University has developed a novel therapeutic protein mixture, which can be used to treat plasma protein imbalances or depletion caused by the adverse events described above. The properties of this protein mixture are beneficial as they lend themselves to an inexpensive manufacturing process and potential improvements in c
linical outcomes.
Fluid replacement as part of resuscitation efforts in clinical care is a cornerstone of treatment especially in cases with severe trauma. The regular usage of these fluids in hospitals requires the mixture to be easily transported, easily stored and applicable across a wide variety of patients. To…