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Column-free Purification of Recombinant Proteins
TS-064270 — Large-scale recombinant proteins in Gram-negative bacteria (i.e., E. coli) are of significant interest in recombinant protein/enzyme production. These proteins exhibit wide-ranging applications, including food and beverages, conversion of carbohydrates into fuel ethanol or biodiesel, components for …
  • College: College of Arts & Sciences
  • Inventors: Gopalan, Venkat
  • Licensing Officer: Panic, Ana

Dual ligand systems for cross-coupling of challenging C(sp2) and C(sp3) electrophiles.
TS-059018 — An unusual series of ligand exchange reactions establishes a dualcatalyst system for electroreductive alkyl-aryl cross-electrophile couplings of previously incompatible substrate combinations.
Cross-electrophile coupling (XEC) reactions of aryl and alkyl electrophiles are desirable methodologies for C–C bond formation but are limited to specific substrate classes. Couplings of widely-available electrophiles such as aryl chlorides or triflates are currently unknown with any alkyl b…
  • College: College of Arts & Sciences
  • Inventors: Sevov, Christo; Hamby, Taylor
  • Licensing Officer: Panic, Ana

Enhancing the mechanical performance of resistance spot welding of aluminum alloys to steel using chromium-rich Interlayers
TS-054040 — This is a new method of resistance spot welding of aluminum alloy and advanced high strength steel that creates a stronger bond by using a chromium-rich interlayer. The interlayer improves joint strength, ductility, and toughness compared to traditional methods.
Resistance welding is used to combine two metals at one point. This technique is used extensively in automotive manufacturing, combining an aluminum (Al) to an advanced high strength steel (AHSS) structure. Welding Al and AHSS together directly, however, does not create a high-quality bond, due to…
  • College: College of Engineering (COE)
  • Inventors: Ramirez, Antonio; Lara, Bryan; Reghine Giorjao, Rafael Arthur
  • Licensing Officer: Zinn, Ryan

Out-of-Plane Fluidic Actuator for Curved Surface Applications
TS-050464 — Experience the future of fluidic control with our out-of-plane feedback-type fluidic oscillator. Revolutionize your engineering applications with unmatched precision, adaptability, and efficiency. Embrace innovation and elevate your industry standards with our groundbreaking bistable fluidic actuator design which uses naturally occurring fluid dynamic instabilities instead of moving parts to create an oscillating jet that is out-of-plane from the fluid inlet port. This inventive technology T2018-374 is just one part of a larger, comprehensive suite of fluidic oscillator technologies offered by The Ohio State University for licensing. To learn more about our other designs, please visit https://oied.osu.edu/find-technologies and search using the term: Fluidic Oscillator.
In the world of power generation and aerospace engineering, the limitations of traditional fluidic oscillators have hampered efforts to enhance turbine blade efficiency and airfoil performance. Current designs struggle to position oscillating jets effectively near the leading edge, where cooling a…
  • College: College of Engineering (COE)
  • Inventors: Hossain, Mohammad Arif "Arif"; Ameri, Ali; Bons, Jeffrey; Gregory, James "Jim"
  • Licensing Officer: Zinn, Ryan

Capacitive Sensing Method for Integrated Circuit Identification and Authentication
TS-048641 — A method of authenticating an IC die’s origin and uniquely identifying each die with an intrinsic unclonable value through measurement of on-chip capacitance values
Hardware security in Integrated Circuit (IC) designs is of increasing importance in dealing with the insecure, expanding global supply chain of these parts. The ability to trace the origin of a die, combined with the capability to uniquely identify each die provides valuable quantitative measures …
  • College: College of Engineering (COE)
  • Inventors: Khalil, Waleed; Kines, Michael
  • Licensing Officer: Ashouripashaki, Mandana

Novel selective protein purification via tangential flow filtration
TS-046780 — Dr. Andre Palmer’s lab at The Ohio State University has developed a novel purification method to isolate any target protein from a complex mixture. The process purifies a target protein (TP) from a mixture by exploiting molecular size changes that result from the formation of a protein complex consisting of a TP and its TP binding molecule (TPBM). This is accomplished via Tangential Flow Filtration (TFF). This process allows for simple and scalable purification of any protein, providing a wide range of applicability.
Proteins can be used in various medical and research applications including drug delivery, hemolysis therapies, and cancer therapies. However, purification of proteins from complex mixtures can require extensive process development. Current methods for protein purification rely on column chromatog…
  • College: College of Engineering (COE)
  • Inventors: Susin Pires, Ivan; Palmer, Andre
  • Licensing Officer: Schworer, Adam

Development of a Single Component Methacrylate Adhesive Formulation
TS-042066 — A novel hybrid adhesive that combines the non-toxic, high strength properties of methacrylate adhesives with the bonding characteristics of polyurethanes
Despite the utility of methacrylate adhesive chemistry, applications have been limited to industrial and biomedical use cases. This is due to the curing mechanism, which is initiated by either heat, light or a two-component redox system. This invention describes two strategies to create a single-c…
  • College: College of Arts & Sciences
  • Inventors: Parquette, Jonathan; Schricker, Scott
  • Licensing Officer: Dahlman, Jason "Jay"

Development of Non-Foaming High Strength, Single Component Methacrylate/Polyurethane Adhesive
TS-037956 — A single component, moisture-cured methacrylate/polyurethane hybrid adhesive that combines the non-toxic, high strength properties of methacrylate adhesives with the bonding characteristics of polyurethanes
Methacrylate adhesives are strong and can be used on similar or dissimilar materials, such as plastic, metal, composites, and ceramic. They have excellent peel strength, resist abrasion, and stand up to a fair range of temperatures. They also require little preparation of the surfaces to be bonded…
  • College: College of Arts & Sciences
  • Inventors: Parquette, Jonathan; Bewick, Nicholas; Schricker, Scott
  • Licensing Officer: Dahlman, Jason "Jay"

Method for Oil–Water Separation Using Nanoparticles and Binder
TS-037436 — A coating which repels oil and attracts water, creating a highly efficient separation technique.
Across numerous industries, such as oil and natural gas processing, liquid-repellent surfaces are often essential to product development, or even operational sustainability via equipment maintenance. Current liquid repellents are optimized to protect against all liquids, including oil and water (s…
  • College: College of Engineering (COE)
  • Inventors: Martin, Samuel; Bhushan, Bharat; Brown, Philip
  • Licensing Officer: Zinn, Ryan

Method for Repellency of Surfactant-Containing Liquids Using Nanoparticles and Binder
TS-037423 — A surface coating which repels both oil and water.
Materials with a coating that repels both water and oil would be advantageous across a wide variety of industries and products. Benefits of this kind of coating could include anti­fouling, self-cleaning, and anti­smudging capabilities. While modern clear coats and paints do offer protectio…
  • College: College of Engineering (COE)
  • Inventors: Martin, Samuel; Bhushan, Bharat
  • Licensing Officer: Zinn, Ryan

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