TS-053103 — Uncontrolled
hemolysis (i.e., destruction of red blood cells) is characterized by t
he increase of circulating toxic cell-free
hemoglobin,
heme and iron in t
he bloodstream. In vivo, t
he body’s natural supply of plasma scavenger proteins acts to neutra
lize t
hese toxic species. However, t
hese scavenger proteins such as haptoglobin,
hemopexin and transferrin, which detoxify
hemoglobin,
heme and iron, respectively, are depleted in various c
linical conditions such as
hemorrhagic shock, burns, surgery, organ transplantation, sepsis and trauma.
Dr. Andre Palmer’s lab at T
he Ohio State University has developed a novel t
herapeutic protein mixture, which can be used to treat plasma protein imbalances or depletion caused by t
he adverse events described above. T
he properties of this protein mixture are beneficial as t
hey lend t
hemselves to an inexpensive manufacturing process and potential improvements in c
linical outcomes.
Fluid replacement as part of resuscitation efforts in clinical care is a cornerstone of treatment especially in cases with severe trauma. The regular usage of these fluids in hospitals requires the mixture to be easily transported, easily stored and applicable across a wide variety of patients. To…