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Method to improve natural rubber (hevea/guayule)-toughened poly-(3-hydroxybutyrate-co-3-hydroxyvalerate)(PHBV) for food packaging applications
TS-044688 — Nearly all plastics that are used to produce packaging materials are petroleum-based and non-biodegradable. This makes their use undesirable to consumers in an increasingly sustainability-focused market. Therefore, the development of biologically-derived, biodegradable plastic for packaging materi…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Vodovotz, Yael; Cornish, Katrina; Koelling, Kurt; Venoor, Varun "varun"; Zhao, Xiaoying "Xiaoying"
  • Licensing Officer: Dahlman, Jason "Jay"

Electrophiles for Re-activation of Aged Acetylcholine Esterase
TS-044619 — Organophosphorus (OP) poisons including sarin, VX, and novichoks are lethal agents of chemical warfare. Their toxicity is due to their direct inhibition of acetylcholinesterase (AChE), an enzyme that is vital to the nervous system via regulation of the neurotransmitter acetylcholine (ACh). AChE in…
  • College: College of Arts & Sciences
  • Inventors: Hadad, Christopher; Callam, Christopher; Corrigan, Thomas; Dicken, Rachel; Dogan Ekici, Ozlem; Fitzpatrick, Keegan; Franjesevic, Andrew; McElroy, Craig; McKenney, Ryan; Muthukrishnan, Siva; Sanan, Toby; Vyas, Shubham; Yoder, Ryan; Young, Amneh "Amneh"
  • Licensing Officer: Dahlman, Jason "Jay"

Isolation of Porcine Epidemic Diarrhea Virus (PEDV) strain Iowa106
TS-044567 — Porcine epidemic diarrhea virus (PEDV) appeared in the US in 2013 and has spread rapidly throughout North America. The virus causes gastroenteric disease in adults and is fatal to nursing piglets, whose only protection from the disease is via passive immunity from their mother. Currently, most US …
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Wang, Qiuhong; Oka, Tomoichiro; Saif, Linda
  • Licensing Officer: Dahlman, Jason "Jay"

Biomimetic vitreous substitute with ocular drug delivery
TS-044490 — Methods and compositions for an antioxidant releasing hydrogel vitreous substitute
The vitreous humor is a fragile, transparent tissue between the lens and the retina of the eye that maintains the shape of the eye, acts as a shock absorber, and enables nutrient diffusion to ocular tissues. The vitreous also plays a key role in oxygen homeostasis. Over time, the vitreous degrades…
  • College: College of Engineering (COE)
  • Inventors: Reilly, Katelyn; Reilly, Matthew; Tram, Nguyen "Archie"
  • Licensing Officer: Flammang, Ann Marie

Antimicrobials to Control Campylobacter
TS-044474 — Campylobacter is a leading cause of foodborne disease in humans, affecting more than one million Americans each year. Campylobacteriosis is projected to remain one of the most-frequent causes of disease and death worldwide. Human infection primarily occurs by ingesting contaminated chicken, and tr…
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Rajashekara, Gireesh; Acuna, Ulyana Munoz; Antwi, Janet; Carcache de Blanco, Esperanza; Fuchs, James; Kumar, Anand; Nislow, Corey; Pascall, Melvin
  • Licensing Officer: Dahlman, Jason "Jay"

Nanoparticle Composition for Nucleic Acid Delivery
TS-044109 — Lipid nanoparticles (LNs) usable for the delivery of therapeutic compositions, including, but not limited to nucleic acids (NAs).
Nucleic Acid (NA) based therapies are used to inhibit gene expression. Lipid nanoparticles (LNs) are capable of carrying these therapies into cells. However, this delivery requires overcoming several physiological barriers. For instance, one barrier is the acidic endosome conditions within the cel…
  • College: College of Pharmacy
  • Inventors: Lee, Robert
  • Licensing Officer: Flammang, Ann Marie

Live vaccine candidate for Chagas disease
TS-044084 — Trypanosoma cruzi is a protozoan parasite that causes Chagas disease, a PRV-eligible disease that is the leading cause of heart failure in Latin America. Due to migration of infected hosts from endemic regions, Chagas disease is also a growing public health concern in the USA and other migrant des…
  • College: College of Medicine (COM)
  • Inventors: McGwire, Bradford
  • Licensing Officer: Dahlman, Jason "Jay"

System for Immobilizing the Skull during Transcranial Focused Ultrasound Ablation
TS-043964 — A non-invasive method for immobilizing the skull of a patient undergoing surgery. The device consists of pads for contacting screws from a standard stereotactic frame and a headband that result in immobilization without damage to the skin or skull.
Both stereotactic neurosurgery and transcranial focused ultrasound surgery systems have historically required a stereotactic frame to precisely position and completely immobilize a patient's head to ensure the correct location for the operation. This frame consists of multiple pins that must b…
  • College: College of Medicine (COM)
  • Inventors: Sammartino, Francesco; Beam, Dylan; Krishna, Vibhor
  • Licensing Officer: Flammang, Ann Marie

Translational Activators of the Glutamate Transporter EAAT2 to Treat Neurological and Psychiatric Diseases
TS-043938 — Small molecule technology with novel translational activation mechanism.
Glutamate is a major neurotransmitter in the mammalian central nervous system (CNS) and essential for normal brain function including cognition, memory, and learning. However, the extracellular concentration of glutamate must remain below excitotoxic levels (~ 1 μM) to avoid overstimulation of …
  • College: College of Medicine (COM)
  • Inventors: Lin, Chien-Liang; Hodgetts, Kevin
  • Licensing Officer: Dahlman, Jason "Jay"

Novel Large Scale All-Male Bluegill Production Technology & All-Female Yellow Perch Production Technology
TS-043636 — A novel technique for the large scale production of male bluegill (GMB) stock through selective breeding methods and for large scale production of all female yellow perch fish stock by means of dietary supplements. This technique improves growth rate, size, and survivability. For more information, please see related pdf upload.
  • College: College of Food, Agricultural, and Environmental Sciences (CFAES)
  • Inventors: Wang, Hanping
  • Licensing Officer: Dahlman, Jason "Jay"

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