Multi-Functional Drug Delivery Nanodevice for Precision Medicine
A functionalized DNA nanostructure made through a scaffolded DNA origami molecular self-assembly process to deliver clinically significant concentrations of therapeutics.
This novel therapeutic approach leverages structural nanotechnology to create a DNA nanostructure that acts as a customizable delivery vehicle for therapeutic molecules. The technology allows for a highly tunable and customizable multi-functional drug delivery platform that incorporates interchangeable i) small molecule therapeutics, ii) therapeutic oligonucleotides, and iii) targeting moieties on a single DNA-based nanostructure to specifically target and destroy tumor cells, while leaving healthy tissue unharmed.
The folded DNA nanoparticle was shown to deliver clinically relevant dosages of daunorubicin in a human Acute Myeloid Leukemia multi-drug resistant cell line and refined drug release profiles. Combined with its fast self-assembly and stability in physiological conditions, this DNA nanostructure could be implemented to deliver a wide-range of therapeutic agents and/or nucleic acids in a targetable manner.
Stage of Development